|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that Snx10 and PIKfyve are involved in the regulation of endosome/lysosome homeostasis via the synthesis of PI(3,5)P2 and may point to a new strategy to prevent bone loss.
|
31692073 |
2020 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here, we report a significant down regulation of SNX10 (sorting nexin 10) in human CRC tissues, which is closely related to tumor differentiation, TNM stage, lymph node metastasis and survival period.
|
31208298 |
2020 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with WT littermates, Snx10 KO mice exhibited a significant amelioration in ethanol-induced liver injury and hepatic steatosis.
|
29452206 |
2018 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Snx10 knockout (Snx10 KO) mice and their wild-type (WT) littermates fed either the Lieber-DeCarli liquid alcohol diet or a control liquid diet, and primary cultured WT and Snx10 KO hepatocytes stimulated with ethanol, were used as in vivo and in vitro ALD models, respectively.
|
29452206 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Here we investigated the role of SNX10 in regulating amino-acid metabolism and mTOR signaling pathway activation, as well as the impact on the tumor progression of mouse CRC.
|
29867114 |
2018 |
|
Gastric Adenocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Weak expression of SNX10 is linked to poor prognosis, and is a suitable prognostic biomarker of SA.
|
30487700 |
2018 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with WT littermates, Snx10 KO mice exhibited a significant amelioration in ethanol-induced liver injury and hepatic steatosis.
|
29452206 |
2018 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, this study revealed an essential role of SNX10 in controlling bacterial infection.
|
28903313 |
2017 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
However, studies of the association of sorting nexin 10 with different types of cancer are limited, prompting further study.
|
28381192 |
2017 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats.
|
28381192 |
2017 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of sorting nexin 10 is associated with overexpression of miR-30d during liver cancer progression in rats.
|
28381192 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
However, studies of the association of sorting nexin 10 with different types of cancer are limited, prompting further study.
|
28381192 |
2017 |
|
Colitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, transfer of WT macrophages exacerbated colitis in SNX10(-/-) mice.
|
26856241 |
2016 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Loss of SNX10 function may be a potential promising therapeutic strategy for IBD.
|
26856241 |
2016 |
|
Rickets
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, osteoclast-specific Snx10 knockout had no effect on calcium balance, and therefore led to severe osteopetrosis without rickets.
|
25811986 |
2015 |
|
Hypoplasia of corpus callosum
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Homozygous stop mutation in the SNX10 gene in a consanguineous Iraqi boy with osteopetrosis and corpus callosum hypoplasia.
|
23123320 |
2013 |
|
Bone Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in intracellular vesicular trafficking, these studies may identify a new candidate gene involved in the development of human bone diseases including osteoporosis.
|
22174188 |
2012 |
|
Osteoporosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Since inhibition of vesicular trafficking is essential for osteoclast formation and activity and SNX10 is involved in intracellular vesicular trafficking, these studies may identify a new candidate gene involved in the development of human bone diseases including osteoporosis.
|
22174188 |
2012 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Moreover, we found that SNX10 KO promoted tumorigenesis in the mouse colorectum which could be restored by SNX10 over-expression.
|
29355659 |
2018 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Our results showed that SNX10 deficiency promoted colorectal tumorigenesis in male FVB mice and CRC cell proliferation and survival.
|
29867114 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
Sorting nexin 10 controls mTOR activation through regulating amino-acid metabolism in colorectal cancer.
|
29867114 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in the mouse colorectum and drives inflammation-associated colorectal cancer by a chaperone-mediated autophagy mechanism.
|
29355659 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in CRC and it could be a potential therapeutic target for future development.
|
31208298 |
2020 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Our results showed that SNX10 deficiency promoted colorectal tumorigenesis in male FVB mice and CRC cell proliferation and survival.
|
29867114 |
2018 |
|
Colorectal Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
These findings suggest that SNX10 acts as a tumor suppressor in the mouse colorectum and drives inflammation-associated colorectal cancer by a chaperone-mediated autophagy mechanism.
|
29355659 |
2018 |