|
Alcoholic Intoxication, Chronic
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found markers of chronic alcohol consumption (HEX A), alcohol dependence (FUC and MAN) and chronic alcohol consumption and dependence (GLU).
|
28660791 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A screen of genes encoding B-GUS and GDH was performed for fecal microbiome data from healthy individuals (n = 103) and from CRC patients (n = 53), which revealed a decrease in abundance of taxa with confirmed GDH and HCA transformation activity in CRC patients.
|
31096909 |
2019 |
|
Diabetes
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the course of diabetes and insulin resistance, an intensified defensive activity of cells against the oxidative stress was observed in the undamaged skin, expressed by an increase in the relative content of superoxide dismutase 2 and 3, catalase and the activity of N-acetyl-β-d-hexosaminidase and β-d-glucuronidase.
|
31146169 |
2019 |
|
Inflammatory Bowel Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Bacterial β-glucuronidase alleviates dextran sulfate sodium-induced colitis in mice: A possible crucial new diagnostic and therapeutic target for inflammatory bowel disease.
|
30967260 |
2019 |
|
Nodule
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Promoter::β-glucuronidase fusion showed that the promoter activity was localized in the root infection/differentiation zone during the early stage of rhizobial infection and in the vascular bundle of the mature nodule.
|
30976084 |
2019 |
|
Oral Manifestations
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Oral manifestations in patients affected with MPS VII have never been reported.
|
30653816 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The three algorithms were in agreement in identifying GUSB and HPRT1 as the most stably expressed genes in all thyroid tumors investigated.
|
31645594 |
2019 |
|
Subacute thyroiditis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ROC curve analysis revealed that β-G activity had a high predictive value for destructive processes, namely AIT2 and subacute thyroiditis (AUC 0.846, 95% CI 0.748-0.943) and a cut-off value of 1,480.5 nmol 4-MU/mL plasma/h was able to discriminate between destructive and non-destructive thyroid conditions with 74% sensitivity and 82% specificity.
|
31602365 |
2019 |
|
Periosteal Disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The markers of inflammation [interleukin 1 (IL-1), interleukin 6 (IL-6), tumor necrosis factor α (TNF-α), transforming growth factor β (TGF-β) and β-glucuronidase (GLU)] as well as apoptosis [Bax, Bax/Bcl-2 ratio, caspase-3 (CAS-3) and nitric oxide (NO)] were significantly elevated in periosteum covering titanium fixations compared to the control group.
|
31781128 |
2019 |
|
Agenesis of corpus callosum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The beta-glucuronidase (GUS) activity driven by the promoter of <i>GmTIP2;6</i> was strongly induced in the heat- and ACC-treated transgenic plants and tended to be accumulated in the hypocotyls, vascular bundles, and leaf trichomes.
|
30634702 |
2019 |
|
Premature aging syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutations of the β-glucuronidase protein α-Klotho have been associated with premature aging, and altered cognitive function.
|
29493420 |
2019 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that GUSB and HPRT1 are promising reference genes for normalization of relative qRT-PCR studies in papillary thyroid carcinoma.
|
31645594 |
2019 |
|
Posterior open bite
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Dogs affected with MPS VII had anterior and posterior open bite, maxillary hypoplasia, premolar crowding, and mandibular prognathism.
|
30653816 |
2019 |
|
Aplasia Cutis Congenita
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The beta-glucuronidase (GUS) activity driven by the promoter of <i>GmTIP2;6</i> was strongly induced in the heat- and ACC-treated transgenic plants and tended to be accumulated in the hypocotyls, vascular bundles, and leaf trichomes.
|
30634702 |
2019 |
|
Hyperthyroidism secondary to amiodarone
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Plasma Beta-Glucuronidase Activity: A Novel Tool to Distinguish Type 1 from Type 2 Amiodarone-Induced Thyrotoxicosis?
|
31602365 |
2019 |
|
Congenital kyphoscoliosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with MPS VII exhibit progressive skeletal deformity including kyphoscoliosis and joint dysplasia, which decrease quality of life and increase mortality.
|
31442675 |
2019 |
|
Skin callus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The system is tightly regulated and highly sensitive to DEX application, with 6 h of induction sufficient to induce high levels of GUS activity in transgenic callus.
|
31615413 |
2019 |
|
Class III malocclusion
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dogs affected with MPS VII had anterior and posterior open bite, maxillary hypoplasia, premolar crowding, and mandibular prognathism.
|
30653816 |
2019 |
|
Kyphoscoliosis deformity of spine
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with MPS VII exhibit progressive skeletal deformity including kyphoscoliosis and joint dysplasia, which decrease quality of life and increase mortality.
|
31442675 |
2019 |
|
Acquired Kyphoscoliosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with MPS VII exhibit progressive skeletal deformity including kyphoscoliosis and joint dysplasia, which decrease quality of life and increase mortality.
|
31442675 |
2019 |
|
Coronary heart disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We have implicated mutations in GATA3, KCNH2, ENG, FLNA, and GUSB genes as an underlying risk factor for CHD in DS patients.
|
30105468 |
2018 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
It has been successfully used to detect and image endogenous GLU in various hepatoma carcinoma cells, tumor tissues, and tumor-bearing mouse models, for cancer diagnosis and therapy.
|
29400050 |
2018 |
|
Speech Delay
|
0.010 |
Biomarker
|
disease |
BEFREE |
Most patients with MPS VII have intellectual disability and severely delayed speech development, usually associated with hearing impairment.
|
30442188 |
2018 |
|
Drug usage
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
It could also evaluate real intestinal distribution and real-time variations of GLU in development and growth, all of which are very helpful to guide rational drug use in the clinic.
|
29400050 |
2018 |
|
Liver calculus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our clinical observations and experimental data indicate that LPS could induce the increased expression and secretion of endogenous β-glucuronidase via a signaling cascade of PKC/NF-κB/c-myc in hepatocytes and intrahepatic biliary epithelial cells, and endogenous β-glucuronidase might play a possible role in the formation of hepatolithiasis.
|
29188532 |
2018 |