|
Nasopharyngeal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
Molecular cloning and characterization of NAG-7: a novel gene downregulated in human nasopharyngeal carcinoma.
|
11780420 |
2001 |
|
Nasopharyngeal carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
The NAG7 eukaryotic expression vector was constructed and transfected into NPC cell line HNE1 with liposome.
|
11921446 |
2002 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This study was designed to investigate the expression levels of NGX6, NAG-7 and BRD7 genes in human gastric and colorectal cancer tissues, and their corresponding normal tissues, and to investigate whether these genes play a role in the pathogenesis of gastric and colorectal cancers.
|
12918109 |
2003 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
This seems to suggest that NAG-7 and BRD7 genes may not play a role in gastric and colorectal carcinogenesis.
|
12918109 |
2003 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
These observations indicate that NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ERalpha and the H-ras/p-c-Raf and JNK2/AP-1/MMP1 signaling pathways.
|
19591174 |
2009 |
|
Nasopharyngeal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These observations indicate that NAG7 plays a potential role in promoting nasopharyngeal carcinoma invasion by regulation of ERalpha and the H-ras/p-c-Raf and JNK2/AP-1/MMP1 signaling pathways.
|
19591174 |
2009 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Our previous studies have found that LINC00312 could inhibit proliferation and induce apoptosis in nasopharyngeal carcinoma (NPC) cells but also stimulate NPC cell invasion.
|
23529758 |
2013 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
These observations indicated that LINC00312 could represent a potential biomarker for metastasis, progression and prognosis in NPC.
|
23529758 |
2013 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Positive expression of LINC00312 was negatively correlated with tumor size (P < 0.001) but positively correlated with lymph node metastasis (P = 0.002).
|
23529758 |
2013 |
|
Nasopharyngeal carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We also found that LINC00312 was strongly negatively correlated with EBER-1, a non-coding RNA transcribed by Epstein-Barr Virus, in NPC (r = -0.384, P < 0.001).
|
23529758 |
2013 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
In the final logistic regression analysis model, the abnormal expression of LINC00312 and EBER-1 were found to be independent contributors to nasopharyngeal carcinogenesis (P < 0.001, P < 0.001, respectively).
|
23529758 |
2013 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Positive expression of LINC00312 was negatively correlated with tumor size (P < 0.001) but positively correlated with lymph node metastasis (P = 0.002).
|
23529758 |
2013 |
|
Tumor Cell Invasion
|
0.060 |
AlteredExpression
|
phenotype |
BEFREE |
The migration test revealed that the downregulation of miR-197-3p and overexpression of LINC00312 inhibited cell migration and invasion abilities, while the overexpression of miR-197-3p and the upregulation of LINC00312 promoted cell migration and invasion.
|
27631965 |
2016 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
LINC00312 inhibited BC cell invasion and metastasis through mediating miR-197-3p.
|
27631965 |
2016 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
LINC00312 inhibited BC cell invasion and metastasis through mediating miR-197-3p.
|
27631965 |
2016 |
|
Bladder Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
LINC00312 inhibited BC cell invasion and metastasis through mediating miR-197-3p.
|
27631965 |
2016 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
LINC00312 inhibited BC cell invasion and metastasis through mediating miR-197-3p.
|
27631965 |
2016 |
|
Tumor Cell Invasion
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Overexpression of long intergenic noncoding RNA LINC00312 inhibits the invasion and migration of thyroid cancer cells by down-regulating microRNA-197-3p.
|
28539331 |
2017 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, the low expression of linc00312 was associated with the Tumor‑Node‑Metastasis stage of NSCLC (P<0.05), whereas the high expression of linc00673 was related with the histological types of NSCLC (P<0.05).
|
28849087 |
2017 |
|
Neoplasms
|
0.040 |
AlteredExpression
|
group |
BEFREE |
In addition, the low expression of linc00312 was associated with the Tumor‑Node‑Metastasis stage of NSCLC (P<0.05), whereas the high expression of linc00673 was related with the histological types of NSCLC (P<0.05).
|
28849087 |
2017 |
|
Malignant Neoplasms
|
0.020 |
GeneticVariation
|
group |
BEFREE |
No association was observed for in utero exposure with solid cancer risk [ERR per 10 mGy: -0.007; 95% confidence interval (CI): <-0.107; 0.148] or with hematological malignancy risk (ERR/10 mGy: -0.011; 95% CI: <-0.015; 0.099).
|
28715276 |
2017 |
|
Malignant neoplasm of thyroid
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In comparison with adjacent normal tissues, the expression of LINC00312 is down-regulated and the expression of <i>miR-197-3p</i> is up-regulated in TC tissues.
|
28539331 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In addition, the low expression of linc00312 was associated with the Tumor‑Node‑Metastasis stage of NSCLC (P<0.05), whereas the high expression of linc00673 was related with the histological types of NSCLC (P<0.05).
|
28849087 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings indicated that linc00312 could be a novel diagnosis biomarker and a promising therapeutic target for NSCLC.
|
28338293 |
2017 |
|
Thyroid Neoplasm
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In comparison with adjacent normal tissues, the expression of LINC00312 is down-regulated and the expression of <i>miR-197-3p</i> is up-regulated in TC tissues.
|
28539331 |
2017 |