|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Choline alfoscerate (α-GPC) is a common choline compound and acetylcholine precursor in the brain, which has been shown to be effective in the treatment of Alzheimer's disease and dementia.
|
27765578 |
2017 |
|
Anemia, Hemolytic, Congenital
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The serum metabonomics study showed that the LDLR<sup>-/-</sup> ,PSGL-1<sup>-/-</sup> mice had higher levels of HDL, valine, acetate, pyruvate, choline, PC, GPC and glycine, and lower levels of LDL+VLDL and lactate at the early stage of atherosclerosis, while lactate, citrate and glutamine showed statistical significance at the late stage of atherosclerosis.
|
29483823 |
2018 |
|
Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The serum metabonomics study showed that the LDLR<sup>-/-</sup> ,PSGL-1<sup>-/-</sup> mice had higher levels of HDL, valine, acetate, pyruvate, choline, PC, GPC and glycine, and lower levels of LDL+VLDL and lactate at the early stage of atherosclerosis, while lactate, citrate and glutamine showed statistical significance at the late stage of atherosclerosis.
|
29483823 |
2018 |
|
Atopic keratoconjunctivitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
|
17926108 |
2007 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Multi-ethnic genome-wide association study for atrial fibrillation.
|
29892015 |
2018 |
|
Atrial Fibrillation
|
0.400 |
GeneticVariation
|
disease |
GWASCAT |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Atrial Fibrillation
|
0.400 |
Biomarker
|
disease |
CTD_human |
Biobank-driven genomic discovery yields new insight into atrial fibrillation biology.
|
30061737 |
2018 |
|
Bulla of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the actual sn-2 acetyl glycerophosphocholine species that result in this PAF agonistic activity, we measured PAF and related sn-2 acetyl GPCs in fresh blister fluid samples from bullous pemphigoid and noninflammatory (suction-induced) bullae by mass spectrometry.
|
9990675 |
1998 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Our objective was to use Mendelian randomization to evaluate whether SZ increased risk for developing EOC or the converse, and, whether SZ impacted 1- or 2-glycerophosphocholine (1- or 2-GPC) metabolites.
|
31844628 |
2019 |
|
Carcinoma, Ovarian Epithelial
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The increase in the major choline-containing metabolite phosphocholine (PCho) in EOC compared with normal and nontumoral immortalized counterparts (EONT) may derive from (a) enhanced choline transport and choline kinase (ChoK)-mediated phosphorylation, (b) increased PC-specific phospholipase C (PC-plc) activity, and (c) increased intracellular choline production by PC deacylation plus glycerophosphocholine-phosphodiesterase (GPC-pd) or by phospholipase D (pld)-mediated PC catabolism followed by choline phosphorylation.
|
20179205 |
2010 |
|
Cerebrovascular accident
|
0.010 |
Biomarker
|
group |
BEFREE |
α-GPC has been shown to enhance memory and cognitive function in stroke and Alzheimer's patients but currently remains untested in patients suffering from epilepsy.
|
27765578 |
2017 |
|
Chills
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cholelithiasis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Conjunctivitis, Giant Papillary
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The study groups comprised 13 patients (13 eyes) with vernal keratoconjunctivitis (VKC group), 13 patients (13 eyes) with atopic keratoconjunctivitis (AKC group), 11 patients (11 eyes) with giant papillary conjunctivitis (GPC group), and 10 healthy volunteers (10 eyes) as a control.
|
17926108 |
2007 |
|
Dementia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Choline alfoscerate (α-GPC) is a common choline compound and acetylcholine precursor in the brain, which has been shown to be effective in the treatment of Alzheimer's disease and dementia.
|
27765578 |
2017 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression.
|
26453561 |
2017 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, currently available evidence was of low quality and therefore inadequate to justify a strong recommendation of using GPD formulations in the management of depression.
|
26453561 |
2017 |
|
Elliptocytosis found
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Elliptocytosis, Hereditary
|
0.420 |
Biomarker
|
disease |
BEFREE |
Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype.
|
1884026 |
1991 |
|
Elliptocytosis, Hereditary
|
0.420 |
Biomarker
|
disease |
HPO |
|
|
|
|
Elliptocytosis, Hereditary
|
0.420 |
GermlineCausalMutation
|
disease |
ORPHANET |
We used naturally mutated red blood cells (RBCs) with primary genetic defects resulting in the absence of protein 4.1 (4.1[-] hereditary elliptocytosis) or glycophorin C (Leach elliptocytosis).
|
8353290 |
1993 |
|
Elliptocytosis, Hereditary
|
0.420 |
GeneticVariation
|
disease |
BEFREE |
The association of the glycophorin C exon 3 deletion with ovalocytosis and malaria susceptibility in the Wosera, Papua New Guinea.
|
11719395 |
2001 |
|
Elliptocytosis, Hereditary
|
0.420 |
GermlineCausalMutation
|
disease |
ORPHANET |
Molecular basis for elliptocytosis associated with glycophorin C and D deficiency in the Leach phenotype.
|
1884026 |
1991 |