Glycogen Storage Disease 0, Muscle
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
|
|
|
Glycogen Storage Disease 0, Muscle
|
0.700 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
Glycogen Storage Disease 0, Muscle
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Cardiomyopathy and exercise intolerance in muscle glycogen storage disease 0.
|
17928598 |
2007 |
Glycogen Storage Disease 0, Muscle
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Muscle glycogen storage disease 0 presenting recurrent syncope with weakness and myalgia.
|
21958591 |
2012 |
Glycogen Storage Disease 0, Muscle
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Prevalence of exertional rhabdomyolysis in endurance horses in the Pacific Northwestern United States.
|
24579562 |
2015 |
Glycogen Storage Disease 0, Muscle
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
Glycogen Storage Disease 0, Muscle
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Glycogen Storage Disease 0, Muscle
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Left Ventricular Hypertrophy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Left atrial hypertrophy
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Tonic - clonic seizures
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We conclude that mutations of the GSY gene are unlikely to play a major role in the predisposition to NIDDM in our families.
|
7913686 |
1994 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the M416V polymorphism of GYS1 gene is not associated with insulin resistance in type 2 diabetes.
|
12870167 |
2003 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) insulin stimulates GYS1 mRNA expression; and 2) impaired stimulation of GYS1 gene expression by insulin in patients with type 2 diabetes is acquired and most likely is secondary to chronic hyperglycemia.
|
10770201 |
2000 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The A2 allele of the XbaI polymorphism in the GYS1 confers an increased susceptibility to different features of the metabolic syndrome and Type II diabetes.
|
10447527 |
1999 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
These findings indicate that the M416V mutation of the GYS1 gene is one of the factors contributing to the insulin resistance in the Japanese population and may play some role in the pathogenesis of NIDDM.
|
9267990 |
1997 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The glycogen synthase gene (GYS1), which encodes the rate-limiting enzyme for glycogen synthesis, is a promising candidate gene for NIDDM.
|
9389424 |
1997 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The Met416Val polymorphism of GYS1 gene was not significantly associated with the risk of type 2 DM (adjusted OR = 1.67; 95% CI: 0.73 - 3.81, P = 0.223).
|
12411100 |
2002 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In males the GYS1 XbaI T-allele (hazard ratio (HR) 1.9 [1.2-2.9]), T2D (2.5 [1.7-3.8]), earlier CV events (1.7 [1.2-2.5]), physical inactivity (1.9 [1.2-2.9]) and smoking (1.5 [1.0-2.3]) predicted CV mortality.
|
17356695 |
2007 |
Diabetes Mellitus, Non-Insulin-Dependent
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We have found a significant association of NIDDM with GYS1 genotypes (p = 0.009), and with common GYS1 alleles (p = 0.022) in the Pima Indians.
|
8721777 |
1996 |
Hyperglycemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Experiment 2 showed lower Glut1, Gys1 and Mct4 expression and higher Mct1 expression in the hyperglycemia group, relative to the control group (p < 0.05).
|
29532970 |
2018 |
Hyperglycemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We conclude that 1) insulin stimulates GYS1 mRNA expression; and 2) impaired stimulation of GYS1 gene expression by insulin in patients with type 2 diabetes is acquired and most likely is secondary to chronic hyperglycemia.
|
10770201 |
2000 |
Hyperglycemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association of GYS1 and beta(3)-AR gene with postprandial hyperglycemia and serum uric acid in type 2 diabetes mellitus.
|
12411100 |
2002 |
Metabolic Syndrome X
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The muscle glycogen synthase gene (GYS1) has been associated with type 2 diabetes (T2D), the metabolic syndrome (MetS), male myocardial infarction and a defective increase in muscle glycogen synthase protein in response to exercise.
|
17356695 |
2007 |
Metabolic Syndrome X
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The A2 allele of the XbaI polymorphism in the GYS1 confers an increased susceptibility to different features of the metabolic syndrome and Type II diabetes.
|
10447527 |
1999 |