GZMA, granzyme A, 3001

N. diseases: 65; N. variants: 0
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.020 GeneticVariation disease LHGDN Moreover, the VDR gene variants might regulate cytotoxic T-cell response via 1, 25(OH)(2) D(3) mediated suppression of granzyme A expression in tuberculosis. 19014932 2009
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 GeneticVariation disease BEFREE The expression of CTLA4, CD3, and granzyme A (GZMA) were validated on 30 cases of Chinese GC. 30422018 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 GeneticVariation disease BEFREE The expression of CTLA4, CD3, and granzyme A (GZMA) were validated on 30 cases of Chinese GC. 30422018 2019
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.300 Biomarker disease CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136 2014
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE In contrast to exposure to mf, exposure to cancer cell lines increased the phagocytic ability of monocytes and reduced their ability to induce T cell proliferation and to expand Granzyme A+ CD8+ T cells. 29668679 2018
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.040 Biomarker group BEFREE Integrated methylation and expression data (along with publicly available, ENCODE-generated histone ChIP Seq and DNAse hypersensitivity data) predict that epigenetic regulation is a primary factor driving transcriptional activation of a number of genes crucial to immunity in cancer, including T cell receptor genes (e.g., CD3D, CD3E), CTLA4, and GZMA. 30885360 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE Integrated methylation and expression data (along with publicly available, ENCODE-generated histone ChIP Seq and DNAse hypersensitivity data) predict that epigenetic regulation is a primary factor driving transcriptional activation of a number of genes crucial to immunity in cancer, including T cell receptor genes (e.g., CD3D, CD3E), CTLA4, and GZMA. 30885360 2019
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.040 Biomarker group BEFREE In contrast to exposure to mf, exposure to cancer cell lines increased the phagocytic ability of monocytes and reduced their ability to induce T cell proliferation and to expand Granzyme A+ CD8+ T cells. 29668679 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.030 Biomarker disease BEFREE The purpose of this study was to evaluate the contribution of GzmA to the pathogenesis of RA in vivo and to examine the possibility that GzmA acting via tumor necrosis factor (TNF) stimulates osteoclastogenesis. 27598995 2017
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.030 Biomarker disease BEFREE Astrocyte cluster 8 (MMP7, SERPINA3, GZMA and CLIC1) and microglial cluster 2 (DSG2 and TNFRSF25) were reproducibly elevated in MS and had a significant and reproducible correlation with MS severity suggesting their pathogenic role. 30553167 2019
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.030 Biomarker disease BEFREE This study identified many DNA methylations and genes as important risk factors for MS and provided novel evidence on the association between circulating MICB and Granzyme A and MS. We also showed that the interaction among DDR1, MICB and GZMA and interaction among METTL21B, METTL1 and TSFM may participate in the pathogenesis of MS. 31321514 2019
CUI: C0003864
Disease: Arthritis
Arthritis 		0.020 Biomarker disease BEFREE Chikungunya virus requires host granzyme A to drive joint inflammation. 28356507 2017
CUI: C0003864
Disease: Arthritis
Arthritis 		0.020 Biomarker disease BEFREE Granzyme A Contributes to Inflammatory Arthritis in Mice Through Stimulation of Osteoclastogenesis. 27598995 2017
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.020 Biomarker disease BEFREE RNA-Seq analysis of chikungunya virus infection and identification of granzyme A as a major promoter of arthritic inflammation. 28207896 2017
CUI: C0008055
Disease: Chikungunya Fever
Chikungunya Fever 		0.020 Biomarker disease BEFREE Chikungunya virus requires host granzyme A to drive joint inflammation. 28356507 2017
CUI: C0343752
Disease: Acute HIV infection
Acute HIV infection 		0.020 Biomarker disease BEFREE This article describes a defect in the coexpression of perforin in granzyme A-positive CD8(+) T cells in lymphoid tissue from patients with acute HIV infection and a reduction in the perforin-dependent nuclear translocation of granzyme A. 12001057 2002
CUI: C0343752
Disease: Acute HIV infection
Acute HIV infection 		0.020 Biomarker disease BEFREE Moreover, these data suggest that expansion of granzyme A(+) HIV-specific cytolytic CD4 T cell responses early during acute HIV infection contributes substantially to the control of viral replication. 22378925 2012
CUI: C0003872
Disease: Arthritis, Psoriatic
Arthritis, Psoriatic 		0.010 Biomarker disease BEFREE TCRβ sequencing showed these cells are polyclonal in PsA (median clonality = 0.08), whilst RNA-seq and deep-immunophenotyping revealed that PsA synovial Tc17 cells have hallmarks of Th17 (RORC/IL23R/CCR6/CD161) and Tc1 cells (granzyme A/B). 31677365 2020
CUI: C0009324
Disease: Ulcerative Colitis
Ulcerative Colitis 		0.010 Biomarker disease BEFREE Levels of GZMA and ITGAE mRNAs in colon tissues can identify patients with UC who are most likely to benefit from etrolizumab; expression levels decrease with etrolizumab administration in biomarker(high) patients. 26522261 2016
CUI: C0013537
Disease: Eclampsia
Eclampsia 		0.010 Biomarker disease BEFREE GZMA) are predicted to play significant roles in the progress of EOPET, which will be confirmed by experiments in future. 28759171 2017
CUI: C0013589
Disease: Ectromelia
Ectromelia 		0.010 Biomarker disease BEFREE In this paper, we show that mice lacking both granzyme A (gzmA) and granzyme B (gzmB), which are, beside perforin, key constituents of cytolytic vesicles, are as incapable as are perforin-deficient mice of controlling primary infections by the natural mouse pathogen ectromelia, a poxvirus. 10570179 1999
CUI: C0018133
Disease: Graft-vs-Host Disease
Graft-vs-Host Disease 		0.010 Biomarker disease BEFREE We herewith identify GZMA as critical effector molecule of human Treg function for gastrointestinal immune response in an experimental GvHD model. 25928296 2015
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.010 Biomarker group BEFREE Granzyme A, a noncytolytic component of CD8(+) cell granules, restricts the spread of herpes simplex virus in the peripheral nervous systems of experimentally infected mice. 10623769 2000
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 Biomarker phenotype LHGDN Thus, the granule secretory pathway plays an unexpected role in inflammation, with GzmA acting as an endogenous modulator. 18951048 2008
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 Biomarker disease BEFREE GC-induced GZMA expression could thus be a useful early biomarker for "personalized" ALL therapy. 17310274 2007