|
Abnormal bone structure
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The beta globin 3' enhancer element confers regulated expression on the human gamma globin gene in the human embryonic-fetal erythroleukemia cell line K562.
|
1993224 |
1991 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.
|
1689192 |
1990 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have analysed the expression of cloned human fetal gamma-globin genes introduced into murine erythroleukemia cells by a protoplast fusion procedure.
|
3463509 |
1986 |
|
Acute Erythroblastic Leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Binding of SSP to the stage selector element (SSE) in the proximal gamma-globin promoter is integral to the competitive silencing of a linked beta-promoter in embryonic/fetal stage erythroleukemia (K562) cells.
|
7828600 |
1995 |
|
Acute Erythroblastic Leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
High-resolution analysis of the human gamma-globin gene promoter in K562 erythroleukemia cell chromatin.
|
3165297 |
1988 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression of human gamma-globin genes in human erythroleukemia (K562) cells.
|
2445753 |
1987 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Single-copy transduction and expression of human gamma-globin in K562 erythroleukemia cells using recombinant adeno-associated virus vectors: the effect of mutations in NF-E2 and GATA-1 binding motifs within the hypersensitivity site 2 enhancer.
|
8400240 |
1993 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells.
|
30257864 |
2018 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reductions in gamma-globin mRNA levels restricted to the cytoplasm of 5-fluorouridine treated K-562 human erythroleukemia cells.
|
2369550 |
1990 |
|
Acute Erythroblastic Leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
DMF recruited Nrf2 to the γ-globin promoters and the locus control region of the β-globin locus in erythroleukemia cells, elevated HbF in SCD donor-derived erythroid progenitors, and reduced hypoxia-induced sickling.
|
29046485 |
2017 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
More importantly, PNA-mediated induction of endogenous gamma-globin gene expression was also demonstrated in K562 human erythroleukemia cells.
|
10373600 |
1999 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
K562 human erythroleukemia cells can be induced by hemin and other stimuli to produce hemoglobin and actively express epsilon- and gamma-globin genes but not the adult-like beta-globin gene.
|
2457030 |
1988 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we used nuclear extracts from murine erythroleukemia cells to purify a protein complex that binds the HPFH -198 gamma-globin gene promoter.
|
17114178 |
2007 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Murine erythroleukemia cell line GM979 contains factors that can activate silent chromosomal human gamma-globin genes.
|
1848707 |
1991 |
|
Acute Erythroblastic Leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine the effect of fragments containing LAR sequences on globin gene expression, mRNA from a marked gamma-globin gene linked to LAR fragments was assayed in stably transfected K562 erythroleukemia cells.
|
2339058 |
1990 |
|
Acute Erythroblastic Leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this report, we compare the function of the human beta-globin locus control region (LCR) in three K562 erythroleukemia cell assays, including (1) a transient transfection assay for "classical" enhancer activity, (2) a colony assay that detects "productive integration events," and (3) an assay that detects the ability of LCR fragments to confer hemin inducibility on linked, stably integrated gamma-globin promoters.
|
1709381 |
1991 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
The early phase of experimental acute renal failure. I. Intratubular pressure and obstruction.
|
562503 |
1977 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
Morphologic demonstration of tubular obstruction in acute renal failure.
|
851170 |
1977 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
The early phase of experimental acute renal failure. I. Intratubular pressure and obstruction.
|
562503 |
1977 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
Morphologic demonstration of tubular obstruction in acute renal failure.
|
851170 |
1977 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Erythroid-specific mRNAs encoding gamma-globin and erythroid delta-aminolevulinate synthase were found to be expressed in blasts from most of these cases, indicating that majorities of the blasts in M7 and TMD cases have erythroid and megakaryocytic phenotypes.
|
7647001 |
1995 |
|
Adult Erythroleukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.
|
1689192 |
1990 |
|
Adult Erythroleukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this report, we compare the function of the human beta-globin locus control region (LCR) in three K562 erythroleukemia cell assays, including (1) a transient transfection assay for "classical" enhancer activity, (2) a colony assay that detects "productive integration events," and (3) an assay that detects the ability of LCR fragments to confer hemin inducibility on linked, stably integrated gamma-globin promoters.
|
1709381 |
1991 |
|
Adult Erythroleukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
K562 human erythroleukemia cells can be induced by hemin and other stimuli to produce hemoglobin and actively express epsilon- and gamma-globin genes but not the adult-like beta-globin gene.
|
2457030 |
1988 |