HDAC2, histone deacetylase 2, 3066

N. diseases: 257; N. variants: 3
Disease: Schizophrenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease PSYGENET These observations support the view of HDAC2 as a promising new target for schizophrenia treatment. 22864611 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE These observations support the view of HDAC2 as a promising new target for schizophrenia treatment. 22864611 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE In addition, the TDT did not show any significant associations between HDAC2 and HDAC3 SNPs and schizophrenia (P > 0.05). 23857786 2013
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE Our results provide preliminary evidence that HDAC2 may not confer susceptibility to SCZ in Han Chinese. 26063464 2015
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 AlteredExpression disease BEFREE In adult-age DLPFC, HDAC2 was decreased by 34% in schizophrenia samples compared to controls (p < 10<sup>-4</sup>). 27959513 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 Biomarker disease BEFREE Together, these findings suggest that HDAC2 may represent a novel target to improve synaptic plasticity and cognition in treated schizophrenia patients. 30025863 2018
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.360 AlteredExpression disease BEFREE We previously determined that HDAC2 mRNA levels were lower in dorsolateral prefrontal cortex (DLPFC) tissue from donors with SCZ compared with controls. 30530989 2019