|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypoxia-Inducible Factor 1α Is a Critical Downstream Mediator for Hypoxia-Induced Mitogenic Factor (FIZZ1/RELMα)-Induced Pulmonary Hypertension.
|
26586659 |
2016 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that the frequency of GT(n) repeats in pediatric heart failure (HF) reflects plasma biomarkers of different disease processes: the soluble receptor for advance glycation end products (sRAGE, marking cellular activation), oxLDL (oxidative stress), NGAL (impaired renal function), HIF-1α (hypoxia) and hsCRP (inflammation).
|
25822459 |
2015 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings show a crucial role of LRP1/Pyk2/HIF-1α in hypoxia-induced cardiomyocyte SERCA2 downregulation, a pathophysiological process closely associated with heart failure.
|
25968337 |
2015 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that the frequency of GT(n) repeats in pediatric heart failure (HF) reflects plasma biomarkers of different disease processes: the soluble receptor for advance glycation end products (sRAGE, marking cellular activation), oxLDL (oxidative stress), NGAL (impaired renal function), HIF-1α (hypoxia) and hsCRP (inflammation).
|
25822459 |
2015 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our findings show a crucial role of LRP1/Pyk2/HIF-1α in hypoxia-induced cardiomyocyte SERCA2 downregulation, a pathophysiological process closely associated with heart failure.
|
25968337 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
BMP4 acts downstream of HIF-1 and mediates hypoxia-induced up-regulation of TRPC, leading to increased basal [Ca(2+)]i in PASMCs, promoting CHPH pathogenesis.
|
25824146 |
2015 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Dysregulation of HIF-1- and HIF-2-mediated transcription leads to imbalance of pro-oxidant and anti-oxidant enzyme gene expression resulting in increased reactive oxygen species (ROS) generation in the chemosensory reflex which is central for developing hypertension.
|
25772710 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Accumulation of hypoxia inducible factor-1α (HIF-1α) is commonly an acute and beneficial response to hypoxia, whereas chronically elevated HIF-1α is associated with multiple disease conditions, including preeclampsia, a serious hypertensive disease of pregnancy.
|
25847948 |
2015 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
These observations suggest that altered glucose metabolism and G6PD overactivation play a key role in switching the PASM cells from the contractile to synthetic phenotype by increasing Sp1 and HIF-1α, which suppresses myocardin, a key cofactor that maintains smooth muscle cell in contractile state, and increasing hypoxia-induced PASM cell growth, and hence contribute to pulmonary arterial remodeling and pathogenesis of pulmonary hypertension.
|
25480333 |
2015 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
|
23988176 |
2014 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Analysis of animal models suggests that by activation of these homeostatic mechanisms, HIF-1 plays a critical protective role in the pathophysiology of ischemic heart disease and pressure-overload heart failure.
|
23988176 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Hypoxia- or PDGF-BB-dependent paxillin tyrosine phosphorylation in pulmonary hypertension is reversed by HIF-1α depletion or imatinib treatment.
|
25231004 |
2014 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Recently, proangiogenic factors hypoxia-inducible factor-1 alpha (HIF-1α) and vascular endothelial growth factor (VEGF) have been known to promote left ventricular myocardial angiogenesis and lead to cardiac hypertrophy, and this would be involved in RV hypertrophy of PH patients.
|
25301555 |
2014 |
|
Heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The gene MYC, RELA, HIF1A, NFκB1 and SMAD3 are as hub nodes in our transcriptional network and have a close relationship with heart failure.
|
23640436 |
2013 |
|
Congestive heart failure
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The gene MYC, RELA, HIF1A, NFκB1 and SMAD3 are as hub nodes in our transcriptional network and have a close relationship with heart failure.
|
23640436 |
2013 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
P-PIC TLR3 KO mice did not develop hypertension and placental HIF-1α, NF-κBp50, miR-210, STAT6, and IL-4 levels were unchanged.
|
23844087 |
2013 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Compromised PASMC HIF-1α expression may contribute to the heightened vasoconstriction that characterizes pulmonary hypertension.
|
23513056 |
2013 |
|
Hypertensive disease
|
0.600 |
AlteredExpression
|
group |
BEFREE |
Thus, the balance between HIF-1α and HIF-2α expression in keratinocytes is a control element of both tissue perfusion and systemic arterial pressure, with potential implications in human hypertension.
|
24101470 |
2013 |
|
Hypertensive disease
|
0.600 |
Therapeutic
|
group |
CTD_human |
These results suggest that an abnormal HIF-1α in the renal medulla may represent a novel mechanism mediating salt-sensitive hypertension in Dahl S rats and that induction of HIF-1α levels in the renal medulla could be a therapeutic approach for the treatment of salt-sensitive hypertension.
|
22349312 |
2012 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our investigation concludes that gelsolin is an important contributor to heart failure progression through novel mechanisms of HIF-1alpha and DNase I activation and downregulation of antiapoptotic survival factors.
|
19246681 |
2009 |
|
Congestive heart failure
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our investigation concludes that gelsolin is an important contributor to heart failure progression through novel mechanisms of HIF-1alpha and DNase I activation and downregulation of antiapoptotic survival factors.
|
19246681 |
2009 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.
|
18083891 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
LHGDN |
Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer.
|
18083891 |
2008 |
|
Hypertensive disease
|
0.600 |
Biomarker
|
group |
BEFREE |
Chronic IH-evoked cardio-respiratory responses are absent in Hif-1alpha+/- mice, and hypertension elicited by chronic IH is absent in mice lacking NFAT3c.
|
18692603 |
2008 |
|
Heart failure
|
0.600 |
Biomarker
|
disease |
RGD |
Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species.
|
17582388 |
2007 |