|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using a state-of-the-art imputation method to analyse the major histocompatibility complex (MHC) region, Ombrello and colleagues narrowed down the association between human leukocyte antigen (HLA)-B51 and Behçet's disease to a model of five amino acids of the HLA-B molecule involved in the binding of the antigen, the interactions with receptors on CD8 T cells and natural killer cells, and the signal peptide of HLA-B, suggesting a crucial role of the cellular cytotoxicity on this disease.
|
25405820 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Although we were not able to formally replicate the association with IL10 and IL23R-IL12RB2, we do report that BD in Iran is strongly associated with HLA-B*51, MICA-A6, and the three HLA-linked SNPs (odds ratio (OR) = 3.38, P = 6.21 × 10(-14); OR = 2.08, P = 1.58 × 10(-13); and OR = 1.67-4.05, P = 1.45 × 10(-04) to 4.79 × 10(-34), respectively).
|
25940109 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this Perspectives article, we describe how Behçet disease and several clinically distinct spondyloarthropathies-all associated with MHC class I (MHC-I) alleles such as HLA-B(*)51, HLA-C(*)0602 and HLA-B(*)27 and epistatic ERAP-1 interactions-have a shared immunopathogenetic basis.
|
26526644 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we need to determine allele-specific effects of ERAP1 variants in the context of HLA-B*51 and HLA-Cw*6, which are associated with Behçet's disease and psoriasis, respectively.
|
26002027 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Behçet's disease (BD), a multi-organ inflammatory disorder, is associated with the presence of the human leukocyte antigen (HLA) HLA-B*51 allele in many ethnic groups.
|
26331842 |
2015 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-B*15, -B*27, -B*57, and -A*26 are independent risk factors for Behçet's disease, while HLA-B*49 and -A*03 are independent class I alleles that are protective for Behçet's disease.
|
26347074 |
2015 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Significant association of HLA-Bw4 with isoleucine at amino-acid position 80 (HLA-Bw4-80I) was found in the HLA-B*51(-) German cohort of BD patients [p(c) = 0.0042, OR = 2.35, 95% CI 1.41 to 3.93) and in the Turkish patients in comparison to the respective controls [p = 0.025, OR = 2.17, 95% CI 1.09 to 4.31].
|
24887019 |
2014 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Therefore, although they were not statistically significant, our data were consistent with an association between ERAP1 and BD as well as with an epistatic interaction between ERAP1 and HLA-B in the Spanish population.
|
25019531 |
2014 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Instead, we mapped the BD association to seven MHC class I (MHC-I) amino acid residues, including anchor residues that critically define the selection and binding of peptides to MHC-I molecules, residues known to influence MHC-I-killer immunoglobulin-like receptor interactions, and a residue located in the signal peptide of HLA-B.
|
24821759 |
2014 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition to HLA-B*51, HLA-B*57 was found as a risk factor in BD, whereas, B*35 was found to be protective.
|
24286189 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the robust HLA-B*51 association in Behçet's disease is explained by a variant located between the HLA-B and MICA genes (rs116799036: odds ratio (OR) = 3.88, P = 9.42 × 10(-50)).
|
23396137 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study identifies GIMAP as a novel susceptibility locus for Behcet's disease.
|
23041938 |
2013 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
CTD_human |
Identification of multiple independent susceptibility loci in the HLA region in Behçet's disease.
|
23396137 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.
|
23291587 |
2013 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
In Sardinia, the BD-associated HLA-B*5101 allele is inherited as part of two distinctive haplotypes differently distributed in patients and controls.
|
23021043 |
2013 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite analysis revealed that the HLA-B*51 gene was strongly associated with Behçet's disease in a Korean population.
|
22258392 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
According to our findings, the frequency of HLAB 51 was significantly higher in BD patients than in controls (p<0.001).
|
22560383 |
2012 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Identification of a susceptibility locus in STAT4 for Behçet's disease in Han Chinese in a genome-wide association study.
|
23001997 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, recent genome-wide association studies have confirmed that HLA-B*51 is primarily associated with BD and that there are multiple susceptibility loci other than HLA-B*51.
|
22042097 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
There is no evidence supporting the use of HLA-B*51 as a diagnostic or prognostic marker for BD, and more clinical data must be collected in addition to basic immunological studies to exploit the potential of HLA-B*51 as a biomarker for BD management.
|
22188278 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, they are associated with two different vasculitides (HLA-B*51 in Behçet's disease and HLA-B*52 in Takayasu's arteritis (TAK)) and with major clinical and immunological differences.
|
22309845 |
2012 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Moreover, HLA-A*26, HLA-B*15, HLA-B*5701 and TNF-α -1031C were independently associated with BD.
|
21059670 |
2011 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recently, several HLA-A or -B alleles have been proposed as possible candidate genes for BD in addition to HLA-B*5101.
|
20868569 |
2011 |
|
Behcet Syndrome
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Since the identification of HLA-B*5101 (and more recently of MICA) as a susceptibility locus for BD, the identification of additional genetic locus/loci, whether inside, or perhaps more importantly outside the MHC has clearly stalled.
|
19684014 |
2010 |
|
Behcet Syndrome
|
0.700 |
Biomarker
|
disease |
BEFREE |
TRIM39 and RNF39 are associated with Behçet's disease independently of HLA-B∗51 and -A∗26.
|
20875797 |
2010 |