|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Sarcoidosis is a systemic granulomatous disease and the DRB1 gene of the DR subregion has been implicated for determining the genetic susceptibility to the disease.
|
9062964 |
1997 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Human leukocyte antigen-DRB1 position 11 residues are a common protective marker for sarcoidosis.
|
11588003 |
2001 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
HLA-DRB1-F(47) was the amino acid residue most associated with sarcoidosis and independently associated with sarcoidosis in whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB1*04 seems to protect against overall sarcoidosis but appears to be a significant risk factor for ocular sarcoidosis as well as for other manifestations associated with HS.
|
21565911 |
2011 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
According to multivariate analysis (MVA), the presence of HLA DRB1*15 was indicated as an independent risk factor for sarcoidosis (OR:2.37; 95% CI: 1.31-4.30, p=0.004).
|
25078644 |
2014 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Among sarcoidosis patients, the HLA A*23, A*80, B*08, B*41, DQB1*05 and DRB1*14 antigens tended to be more common than in the controls, whereas the B*44, B*45, B*51, B*58, DRB1*15 and DRB1*16 alleles were more frequently found in control subjects than in the sarcoidosis patients.
|
23911360 |
2013 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Among the patients with secondary EN, the patient subgroup with sarcoidosis exhibited a significantly increased frequency of HLA-DRB1* 13 compared with healthy controls.
|
11764214 |
2001 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BTNL2 rs206530 A allele frequencies were significantly higher in sarcoidosis with no linkage disequilibrium with HLA-DRB1 alleles, except in the subgroup of patients with Löfgren syndrome where the determinant allele was HLA-DRB1*03.
|
23017494 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
BTNL2 haplotype 4, tagged by the rs2076530 G allele, also remained associated with non-Löfgren sarcoidosis after adjusting for HLA-DRB1 alleles (OR 0.37, P = 0.016).
|
17661910 |
2007 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Conversely, a lack of DRB1*11 and/or DRB1*12 but not DRB3*0201/2 favored the clinical course of sarcoidosis.
|
11169267 |
2001 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Different HLA-DRB1 allele distributions in distinct clinical subgroups of sarcoidosis patients.
|
20187937 |
2010 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
DQB1*02, DQA1*0201/*0501 (Ls) and DRB1*15/*13 (Stage II) were more frequently present in SA than in TB, but after correction, only DRB1*15, DQB1*02, DQA1*0501 were significantly different.
|
18038917 |
2006 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Epitopes of native vimentin are antigenic in the group of HLA-DRB1*0301 positive patients with sarcoidosis.
|
30009963 |
2018 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
ESAT-6 and katG presented by antigen-presenting cells expressing DRB1*1101-induced Th-1 responses from sarcoidosis T cells, thus providing a mechanistic insight for the association of HLA DRB1*1101 with sarcoidosis, and sarcoidosis T cell interaction with microbial antigens.
|
19536643 |
2010 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Finally, multivariate analysis revealed that the CCR2 association was independent of HLA-DRB1*0301 in both Spanish (P = 0.02 vs. controls) and Swedish cohorts (P = 0.002 vs. non-Löfgren sarcoidosis, P = 0.001 vs. controls).
|
18513341 |
2008 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Further, multivariate logistic regression analysis revealed that the presence of DRB1*11(odds ratio [OR] 9) and DRB1*14 (OR 7), and absence of DRB1*07 (OR 63 and DQB1*0201(OR 3) alleles, were independent predictors of sarcoidosis.
|
12600814 |
2003 |
|
Sarcoidosis
|
0.700 |
SusceptibilityMutation
|
disease |
ORPHANET |
Genetic characterization and susceptibility for sarcoidosis in Japanese patients: risk factors of BTNL2 gene polymorphisms and HLA class II alleles.
|
22991420 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility.
|
22952805 |
2012 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
CTD_human |
HLA-DRB1*1101: a significant risk factor for sarcoidosis in blacks and whites.
|
14508706 |
2003 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
HLA-DRB3*0101 as well as DRB1*0301 positive sarcoidosis patients may have the capacity to present specific sarcoidosis associated antigens in such a way that AV2S3+ CD4+ T cells are stimulated preferentially, generating lung restricted AV2S3+ T cell expansions.
|
11923555 |
2002 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
However, this difference might be explained by a secondary association with HLA-DRB1*08 in the HLA-DRB1 gene, which is thought to be the gene primarily responsible for susceptibility to sarcoidosis.
|
9458120 |
1997 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, we also showed the presence of a combined association between DRB1*03 and IFN-gamma 3,3 in sarcoidosis (P = 0.017) and LS patients (P = 0.001).
|
15019280 |
2004 |
|
Sarcoidosis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human leukocyte antigen (HLA)-DRB1*03 is over-represented in LS, and is associated with a good prognosis, whereas HLA-DRB1*15-positive patients have a more chronic course of sarcoidosis.
|
30585624 |
2019 |
|
Sarcoidosis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In a retrospective case-control study, TNF-alpha G-308A, TNF-alpha G-238A, lymphotoxin-alpha (LTA) and HLA-DRB1*03 were genotyped in 625 sarcoidosis patients.
|
20070603 |
2010 |