Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In Black American MS patients, the B7 frequency is slightly increased but Dw2 is still significantly associated with MS. For the HLA-DR antigen series DR2 is shown to have a stronger association to MS than A3 and B7.
|
6953617 |
1982 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The frequencies of Properdin factor B allotypes were studied in 54 multiple sclerosis patients and 58 healthy control subjects, and the association of various phenotypes with HLA-Dw1 and Dw2 antigens (found with decreased and increased frequency in MS patients, respectively) was further studied.
|
6558078 |
1983 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Extensive analysis of restriction fragment length polymorphism using HLA class II and T-cell receptor gene probes has been carried out in an attempt to identify genetic markers more strongly associated with multiple sclerosis than the classically defined antigens DR2, Dw2, and DQw1.
|
2567726 |
1989 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results confirm the proposed positive association of the Dw2 (DRB1*1501 DQA1*0102 DQB1*0602) haplotype with MS in Caucasians in our Turkish population (25 vs. 8, p = 0.003, OR = 3.7).
|
9328791 |
1997 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
ON differs from both MS and controls regarding HLA-Dw2.
|
8899048 |
1996 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The well-established association of DRw15, DQw6, Dw2 alleles and MS susceptibility was confirmed.
|
1361490 |
1992 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The HLA-DR2/Dw2 haplotype is associated with multiple sclerosis (MS) in the North American Caucasian population.
|
1723064 |
1991 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Susceptibility is associated with the MHC class II region, especially HLA-DRB5*0101-HLA-DRB1*1501-HLA-DQA1*0102-HLA-DQB1*0602 haplotypes(hereafter DR2), which dominate genetic contribution to MS risk.
|
19380721 |
2009 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, HLA-DRB5 attenuates MS severity, a finding consistent with HLA-DRB5's proposed role as a modifier in experimental autoimmune encephalomyelitis.
|
18832704 |
2008 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Results on serotyping for "B-cell DW2" antigen are suggestive of an increased frequency of this antigen in chronic progressive MS patients (RR = 2.9, P = 0.01).
|
71339 |
1977 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Multiple sclerosis (MS) has, since the 1970s, been known to be associated with the HLA-Dw2 and -DR2 specificities in Caucasian Europeans and North Americans.
|
1926129 |
1991 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HLA-DR15 haplotypes, including genomic variants of HLA-DRB5, and HLA-DR4 haplotypes affect MS risk.
|
29683085 |
2019 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we observed significant transmission distortion and an intrafamilial association of the MS-associated class II haplotype HLA-Dw2.
|
9065561 |
1997 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This indicates that the Dw2 haplotype, when present in familial MS, may confer a stronger influence in MS susceptibility than generally recognized.
|
8300862 |
1994 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The conclusions were: 1) There were no significantly higher occurrences of HLA-A3, B7, Dw2 or DRw2 in Japanese MS. 2) Japanese MS might nevertheless be associated with the human major histocompatibility complex, because HLA-B40 was significantly less frequent in MS and two anti HLA-DRw sera, 7w008 and 034, reacted positively more often against lymphocytes from MS patients.
|
80838 |
1978 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Conversely to the well-established association of DR2/Dw2 with multiple sclerosis (MS) susceptibility in Caucasoids, several studies have found an association of DR4 in populations from Mediterranean origin.
|
2033119 |
1991 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In fact, analysis of 19 patients homozygous for the MS associated HLA-DR-DQ haplotype HLA-Dw2 showed that this haplotype does not carry the TNF2 allele.
|
8550811 |
1995 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The possibility that the HLA-Dw2, BfS disequilibrium has resulted from a selective advantage conferred on the general community but at the expense of increasing susceptibility to MS should be considered.
|
91230 |
1979 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequencies of HLA-DRB3 * 0202 (100%), HLA-DRB1 * 1302 (67%), HLA-DRB3 * 0301 (67%), and HLA-DQB1 * 0301 (67%) were significantly increased in children with multiple sclerosis and the frequencies of HLA-DRB1 * 1501 (40%) and HLA-DRB5 * 0101 (40%) were significantly increased in children with ADEM.
|
15201511 |
2004 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Surprisingly, these changes which favour a beneficial, disease-downregulating effect of IL-4 and TGF-beta in MS, were found to be confined to HLA-Dw2-positive patients.
|
9345450 |
1995 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
LHGDN |
Thus, HLA-DRB5 attenuates MS severity, a finding consistent with HLA-DRB5's proposed role as a modifier in experimental autoimmune encephalomyelitis.
|
18832704 |
2008 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we evaluated the role of the two functional HLA-DR heterodimers, DR2a (DR alpha paired with the beta chain encoded by DRB5*0101) and DR2b (DR alpha paired with the beta chain encoded by DRB1*1501), that are coexpressed in the multiple sclerosis (MS)-associated haplotype HLA-DR15 Dw2, in presenting myelin basic protein (MBP) peptides to MBP-specific T cell lines (TCL).
|
9258250 |
1997 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This observation supports the hypothesis that "normal" genes, common to all carriers of the DR15,DQ6,Dw2 haplotype, confer the increased genetic susceptibility to MS associated with this haplotype.
|
8093808 |
1993 |
Multiple Sclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Dw2/DR2 phenotype, known to be associated with increased MS susceptibility, was also associated with a later onset of MS and more rapid progression of disease.
|
7061242 |
1982 |
Multiple Sclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We used an extremes-of-outcome design with 48 benign and 20 malignant MS patients to assess whether or not DNA methylation at HLA-DRB1*1501 and/or HLA-DRB5 also contributes to MS phenotypic heterogeneity.
|
20394989 |
2010 |