|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High-mobility group box protein 1 (HMGB1) is a pivotal late mediator involved in the development of sepsis and multiple organ dysfunction syndrome (MODS) in critically ill patients.
|
22047946 |
2012 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Serum markers associated with the acute proinflammatory phase of sepsis (TNFα, IL-1β, and IL-6) rapidly increased and then progressively decreased during the 30-day period post-CLP, concomitant with a progressive increase in RAGE ligands (S100B, <i>N</i>ϵ-[carboxymethyl]lysine, HSP70, and HMGB1).
|
29127203 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
HMGB1 has been associated with divergent clinical conditions such as sepsis, rheumatoid arthritis and atherosclerosis.
|
26605648 |
2015 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High-mobility group box 1 (HMGB1), as a late mediator of sepsis, enhances hyperpermeability, and it is therefore a therapeutic target.
|
25947626 |
2015 |
|
Sepsis
|
0.600 |
Therapeutic
|
disease |
RGD |
Neutralization of receptor for advanced glycation end-products and high mobility group box-1 attenuates septic diaphragm dysfunction in rats with peritonitis.
|
19623040 |
2009 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our study provides new insights in understanding the molecular mechanisms of HMGB1 secretion in sepsis.
|
25517228 |
2015 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High mobility group box 1 (HMGB1) is a NF released extracellularly as a late mediator of lethality in sepsis and as an early mediator of inflammation following injury.
|
16751357 |
2006 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Elevated HMGB1 plasma levels were independent from the presence of sepsis.
|
29862569 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In the present study, we demonstrated that the level of PPARγ is inversely correlated with that of high mobility group box 1 (HMGB1, a late proinflammatory mediator) in patients with sepsis.
|
26721185 |
2016 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Deciphering the mechanism of Huang-Lian-Jie-Du-Decoction on the treatment of sepsis by formula decomposition and metabolomics: Enhancement of cholinergic pathways and inhibition of HMGB-1/TLR4/NF-κB signaling.
|
28434923 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we focused on plasma samples from 2 patients who survived sepsis and exhibited high titer antibodies to HMGB1.
|
31767118 |
2020 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In various insults such as sepsis and ischemia, high-mobility group box 1 (HMGB1) is released extracellularly to induce inflammation.
|
24285082 |
2013 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
High mobility group box-1 protein in patients with suspected community-acquired infections and sepsis: a prospective study.
|
17346334 |
2007 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These data suggest that central HMGB1 might be a potential therapeutic target for septic challenge and that inhibition of brain HMGB1 can protect against multiple organ dysfunction induced by sepsis.
|
30881224 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The expressions of HMGB1 in cortex, hippocampus, and striatum were significantly enhanced in the sepsis group when compared with the sham group.
|
29190939 |
2017 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
HMGB1, an intracellular transcription factor with cytokine properties, is a late mediator in sepsis and ARDS pathobiology, however, the role of HMGB1 in VILI remains poorly described.
|
24370952 |
2014 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This review highlights some of the mechanisms that contribute to location and functions of HMGB1, and focuses on some recent insights on important intracellular effects of HMGB1 during sepsis and trauma.
|
30946496 |
2019 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In this study, we deleted the murine <i>Gstp</i> gene cluster and found that GSTP significantly decreased the mortality of experimental sepsis and reduced related serum level of high mobility group box-1 protein (HMGB1).
|
29520271 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Following the initiation of sepsis, serum HMGB1 continued to increase in the sepsis group and was significantly elevated at 24 h (P<0.05), whereas urine HMGB1 levels decreased significantly at 12 and 24 h (P<0.05).
|
28912856 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We examined the effects of ZGR on HMGB1-mediated septic responses and survival rate in a mouse model of sepsis.
|
28610995 |
2017 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings indicate that HMGB1 interacts with LPS to mediate caspase-11-dependent pyroptosis in lethal sepsis.
|
30314759 |
2018 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Quercetin Exerted Protective Effects in a Rat Model of Sepsis via Inhibition of Reactive Oxygen Species (ROS) and Downregulation of High Mobility Group Box 1 (HMGB1) Protein Expression.
|
31377749 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The expression of α7nAChR, toll-like receptor 4 (TLR4), high mobility group box 1 (HMGB1), and cleaved caspase-3 increased, peaking 24 h during sepsis.
|
31520992 |
2019 |
|
Sepsis
|
0.600 |
Biomarker
|
disease |
BEFREE |
High mobility group box 1 (HMGB1) has been proposed as crucial in the pathogenesis of many diseases including sepsis.
|
29988587 |
2018 |
|
Sepsis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Two polymorphisms were determined as significant risk factors associated with early and late mortality, which may provide insight into the molecular background of SIRS and sepsis, suggesting a possible role for HMGB1 genetics in future prognostic evaluation.
|
18577209 |
2008 |