HMOX1, heme oxygenase 1, 3162

N. diseases: 666; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.700 Biomarker disease HPO
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.700 Biomarker disease CTD_human
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic 		0.400 Biomarker disease HPO
CUI: C1527303
Disease: Chronic Airflow Obstruction
Chronic Airflow Obstruction 		0.300 Biomarker disease CTD_human
CUI: C1841651
Disease: Heme Oxygenase 1 Deficiency
Heme Oxygenase 1 Deficiency 		0.300 Biomarker disease CTD_human
CUI: C0018965
Disease: Hematuria
Hematuria 		0.100 Biomarker phenotype HPO
CUI: C0019209
Disease: Hepatomegaly
Hepatomegaly 		0.100 Biomarker phenotype HPO
CUI: C0033687
Disease: Proteinuria
Proteinuria 		0.100 Biomarker phenotype HPO
CUI: C0456070
Disease: Growth delay
Growth delay 		0.100 Biomarker phenotype HPO
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 Biomarker disease BEFREE Using immunoblotting methods, we further showed that HO-1 protein content was increased in neocortical and vascular samples from AD subjects compared with controls. 7543935 1995
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.060 AlteredExpression disease BEFREE In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs. 8764571 1996
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.060 AlteredExpression disease BEFREE In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs. 8764571 1996
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.050 AlteredExpression disease BEFREE In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs. 8764571 1996
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.050 AlteredExpression disease BEFREE In a human glioblastoma cell line, T98G, treatment with any of three types of NO donors--sodium nitroprusside, 3-morpholinosydnonimine, and S-nitroso-L-glutathione--caused a significant increase in the levels of heme oxygenase-1 mRNA but not in the levels of heme oxygenase-2 and heat-shock protein 70 mRNAs. 8764571 1996
CUI: C0007134
Disease: Renal Cell Carcinoma
Renal Cell Carcinoma 		0.040 Biomarker disease BEFREE Quantitative measurement of heme oxygenase-1 in the human renal adenocarcinoma. 8913885 1996
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.600 AlteredExpression group BEFREE For comparison, HO-1 levels were assayed in RPE cells from four donor eyes with long-standing hypertension. 9134328 1997
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.400 GeneticVariation disease BEFREE Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. 9225984 1997
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.400 GeneticVariation disease BEFREE Here, we show that a (GT)n repeat in the human HO-1 gene promoter region is highly polymorphic, although no particular alleles are associated with AD or PD. 9225984 1997
CUI: C0018995
Disease: Hemochromatosis
Hemochromatosis 		0.200 Biomarker disease MGD Heme oxygenase 1 is required for mammalian iron reutilization. 9380735 1997
CUI: C0015397
Disease: Disorder of eye
Disorder of eye 		0.010 AlteredExpression group BEFREE This was a limited study; additional screening from different donor eyes will be done in order to establish the relationship between RPE, HO-1 expression and eye diseases in which oxidative stress is believed to be a determinant in the pathophysiology. 9134328 1997
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic 		0.400 Biomarker disease CTD_human Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. 9884342 1999
CUI: C0002879
Disease: Anemia, Hemolytic, Acquired
Anemia, Hemolytic, Acquired 		0.300 Biomarker disease CTD_human Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. 9884342 1999
CUI: C0002889
Disease: Anemia, Microangiopathic
Anemia, Microangiopathic 		0.300 Biomarker disease CTD_human Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. 9884342 1999
CUI: C0005779
Disease: Blood Coagulation Disorders
Blood Coagulation Disorders 		0.300 Biomarker group CTD_human Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. 9884342 1999
CUI: C0012715
Disease: Iron Metabolism Disorders
Iron Metabolism Disorders 		0.300 Biomarker group CTD_human Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. 9884342 1999