Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our results show that breast cancer risk-associated SNPs are enriched in the cistromes of FOXA1 and ESR1 and the epigenome of histone H3 lysine 4 monomethylation (H3K4me1) in a cancer- and cell type-specific manner.
|
23001124 |
2012 |
Breast Carcinoma
|
0.600 |
CausalMutation
|
disease |
CGI |
|
|
|
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this resource paper, we present the genome-wide localization analysis of SRC-3 chromatin affinity sites in MCF-7 human breast cancer chromatin and compare the cis binding sites to global cartographies for ER and FoxA1.
|
20181721 |
2010 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Ultrasound assisted gene and photodynamic synergistic therapy with multifunctional FOXA1-siRNA loaded porphyrin microbubbles for enhancing therapeutic efficacy for breast cancer.
|
29758547 |
2018 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
A conserved PR binding element was identified in PR binding regions from both cell lines, but there were distinct patterns of enrichment of known cofactor binding motifs, with FOXA1 sites over-represented in breast cancer cell binding regions and NF1 and AP-1 motifs uniquely enriched in the immortalized normal line.
|
22545144 |
2012 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Up-regulation of the HSP72 by Foxa1 in MCF-7 human breast cancer cell line.
|
19486887 |
2009 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results define a paradigm for estrogen action in breast cancer cells and suggest that regulation of gene expression by nuclear receptors can be compartmentalized into unique transcriptional domains by means of licensing of their activity to cofactors such as FOXA1.
|
16087863 |
2005 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Functional Variant rs4442975 Modulating FOXA1 Binding Affinity Can Influence Bone Marrow Suppression during Neoadjuvant Chemotherapy for Luminal A Type Breast Cancer.
|
30881995 |
2019 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study explored the FOXA1 relationship with luminal and basal breast cancer subtypes, proliferation markers, and survival in breast cancer patients who had received similar treatment.
|
18037662 |
2008 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
FOXA1 levels are decreased in pleural breast cancer metastases after adjuvant endocrine therapy, and this is associated with poor outcome.
|
29972720 |
2018 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Stable expression of FOXA1, but not ERα, reduced the expression of <i>IL6</i> in the FOXA1- and ERα-negative breast cancer MDA-MB-231 cells and TAM-R cells, without affecting the activation of the NF-κB signaling pathways.
|
28270510 |
2017 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The analysis revealed already well-established associations with XBP1 and FOXA1, but also identified a strong association with CT62, a potential immunotherapeutic target with few previous associations with breast cancer.
|
30760519 |
2019 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recently, a groundbreaking study by the Lupien group has shown that risk-associated SNPs of breast cancer are enriched for FOXA1 binding sites, which influences the function of this transcription factor.
|
23427833 |
2013 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Our results show that breast cancer risk-associated SNPs are enriched in the cistromes of FOXA1 and ESR1 and the epigenome of histone H3 lysine 4 monomethylation (H3K4me1) in a cancer- and cell type-specific manner.
|
23001124 |
2012 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interdependency between these three factors in breast cancer and normal mammary development has been suggested, but the specific role for FOXA1 is not known.
|
20501593 |
2010 |
Breast Carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
In addition, the results are consistent with the notion that parity-associated epigenetic silencing of FOXA1 contributes to long-term attenuation of the estrogenic impact on breast cancer development.
|
25234841 |
2014 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The comparison of our signature with two pioneering signatures, the Sorlie's signature and PAM50, suggests a novel marker, FOXA1, in breast cancer classification.
|
26404658 |
2015 |
Breast Carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
This study aims to evaluate the potential value of FOXA1 for controlling gene CpG island methylation in breast cancer.
|
25755696 |
2015 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
FOXA1, a known driver of hormone-receptor positive breast cancer, harbours a mutational hotspot in its promoter leading to overexpression through increased E2F binding.
|
28658208 |
2017 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In normal breast tissue FOXA1 acts throughout mammary development; whereas in breast carcinoma its expression promotes luminal phenotype and correlates with good prognosis.
|
26298189 |
2015 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
FOXA1 immunoreactivity was significantly elevated in the relapse-free breast cancer patients treated with tamoxifen.
|
22476979 |
2012 |
Breast Carcinoma
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
ABC successfully identifies previously characterized functional SNVs, such as the rs4784227 breast cancer risk associated SNP that modulates the affinity of FOXA1 for the chromatin.
|
25995231 |
2015 |
Breast Carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
This is in line with other studies suggesting these SNPs as risk-associated polymorphisms which may lead to a change in the affinity of FOXA1, as a distal enhancer, to <i>TOX3</i> and thus change in <i>TOX3</i> expression, which can eventually affect the risk of breast cancer.
|
31338012 |
2019 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Analyses of an epigenetic switch involved in the activation of pioneer factor FOXA1 leading to the prognostic value of estrogen receptor and FOXA1 co-expression in breast cancer.
|
31562808 |
2019 |
Breast Carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Forkhead box A1 (FOXA1), a transcription factor, plays a crucial role in breast cancer and has been predicted as a target of miR-204.
|
28534958 |
2017 |