Neurofibromatosis 1
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The results for HOX2 and NGFR suggest only loose linkage with the NF1 gene, while no linkage was found between NF1 and the growth hormone locus.
|
2896630 |
1987 |
Neurofibromatosis 1
|
0.030 |
Biomarker
|
disease |
BEFREE |
The best order is pter-pA10-41-EW301-centromere (p17H8)-pHHH202-NF1-EW206-EW207-EW203++ +-CRI-L581-CRI-L946-HOX2-NGFR-qter.
|
2491784 |
1989 |
Neurofibromatosis 1
|
0.030 |
Biomarker
|
disease |
BEFREE |
No linkage was detected between NF1 and CRI-L946 or between HOX-2 and growth hormone.
|
2491782 |
1989 |
leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 627 line, which derives from an HTLV-1+ T-helper leukemia; (3) transcription of 2.3 and 2.6 in both the T-ALL CEM line and four B-ALL lines (interestingly, CALLA- B-ALL lines are constantly 2.3/2.6 RNA+); (4) no HOX-2 gene expression was detected in one T- and two B-ALL lines.
|
1351762 |
1992 |
Childhood Leukemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
In B- and T-ALL cell lines, HOX-2 genes are expressed according to different patterns: (1) widespread transcription (seven of nine genes, including 2.3 and 2.6) in the Peer line bearing the TCR gamma/delta; (2) expression of 2.5, 2.2, and 2.6 in the SEZ 627 line, which derives from an HTLV-1+ T-helper leukemia; (3) transcription of 2.3 and 2.6 in both the T-ALL CEM line and four B-ALL lines (interestingly, CALLA- B-ALL lines are constantly 2.3/2.6 RNA+); (4) no HOX-2 gene expression was detected in one T- and two B-ALL lines.
|
1351762 |
1992 |
Renal Cell Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies.
|
1379214 |
1992 |
Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines.
|
1360433 |
1992 |
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data are compatible with the hypothesis that selected HOX-2 genes play a role in the IL-2/IL-1 beta-induced activation and/or proliferation of normal NK lymphocytes and possibly in the oncogenetic process of some T- and B-ALL.
|
1351762 |
1992 |
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Primary blasts from five T- and five pre-B-ALL showed selective expression of one or more HOX-2 genes, namely 2.5, 2.2, 2.6, and 2.7.
|
1351762 |
1992 |
Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The two uninduced neuroblastoma cell lines show a similar pattern of expression for a number of HOX2 genes although the levels of expression are different for individual cell lines.
|
1360433 |
1992 |
Adult Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines.
|
1360433 |
1992 |
Childhood Glioblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines.
|
1360433 |
1992 |
Central neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The two uninduced neuroblastoma cell lines show a similar pattern of expression for a number of HOX2 genes although the levels of expression are different for individual cell lines.
|
1360433 |
1992 |
Precursor B-cell lymphoblastic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Primary blasts from five T- and five pre-B-ALL showed selective expression of one or more HOX-2 genes, namely 2.5, 2.2, 2.6, and 2.7.
|
1351762 |
1992 |
Renal carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Alterations in HOX gene expression in renal carcinoma can be observed in 2 genes of the HOX-2 locus, HOX-2A and HOX-2E, which are actively expressed in normal kidney and silent in cancer biopsies.
|
1379214 |
1992 |
Glioblastoma Multiforme
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The expression of the genes in the human HOX2 locus has been studied during differentiation of two human neuroblastoma (SH-SY5Y and Kelly), a human glioblastoma (251-MG), and the murine F9 embryonal carcinoma cell lines.
|
1360433 |
1992 |
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data are compatible with the hypothesis that selected HOX-2 genes play a role in the IL-2/IL-1 beta-induced activation and/or proliferation of normal NK lymphocytes and possibly in the oncogenetic process of some T- and B-ALL.
|
1351762 |
1992 |
Childhood Neuroblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The two uninduced neuroblastoma cell lines show a similar pattern of expression for a number of HOX2 genes although the levels of expression are different for individual cell lines.
|
1360433 |
1992 |
Leukemia, Myelocytic, Acute
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Six contiguous genes of the HOX2 locus, highly expressed in acute non-lymphocytic leukemia, are switched off in chronic myelogenous leukemia, suggesting that down-regulation of HOX2 genes might be required for cell maturation of the myeloid lineages.
|
7678830 |
1993 |
CAMPOMELIC DYSPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Due to the distal location of the breakpoints, previously mentioned candidate genes, HOX2 and COL1A1, can be excluded as being involved in CMPD1/SRA1.
|
8348155 |
1993 |
Chromosome 9, trisomy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Of four homeobox transcripts (HoxA7, HoxB4+ ++, HoxB5, and HoxC6) that are expressed in diploid embryos, only HoxA7, HoxB4 and HoxC6 were present in a trisomy 7 embryo, and only HoxB4 and HoxB 5 in triploid embryos and an embryo with trisomy 9.
|
8688592 |
1996 |
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Taken together, these data suggest that nuclear HOXB4 protein may play a role in the regulation of cellular proliferation/adhesion in developing fetal human epidermis and in hyperproliferation conditions, including cancers, in adult epidermis.Published 2002 Wiley-Liss, Inc.
|
11984874 |
2002 |
Dermatologic disorders
|
0.010 |
AlteredExpression
|
group |
BEFREE |
HOXB4 homeodomain protein is expressed in developing epidermis and skin disorders and modulates keratinocyte proliferation.
|
11984874 |
2002 |
Experimental Organism Basal Cell Carcinoma
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We previously have reported HOXB4 gene expression in the basal and suprabasal layers of developing human skin and now show extensive HOXB4 mRNA in psoriatic skin and basal cell carcinoma.
|
11984874 |
2002 |
Carcinoma, Basal Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We previously have reported HOXB4 gene expression in the basal and suprabasal layers of developing human skin and now show extensive HOXB4 mRNA in psoriatic skin and basal cell carcinoma.
|
11984874 |
2002 |