|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
56 adenomas (< or = 10 mm) from 39 patients were analysed for APC, CTNNB1 and K-ras mutations, allelic imbalance on 1p and 18q, microsatellite instability and immunohistochemical expression of HLA-DR, BAX, BCL-2 and Ki-67.
|
12737446 |
2003 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Adenomas had lower mutational rates than did colorectal cancers and showed recurrent alterations in known cancer driver genes (APC, KRAS, FBXW7, TCF7L2) and AIs in chromosomes 5, 7, and 13.
|
27221540 |
2016 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APC gene mutations in a jejunal adenoma causing intussusception in a patient with familial adenomatous polyposis.
|
12522539 |
2002 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APC:T1556fs and STK11 mutations found in duodenal adenomas/ACs highlight the importance of proteins encoded by these genes in tumor development.
|
29525853 |
2018 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APC mutations were detected in 20 per cent (6/30) of the adenomas but in only 1.4 per cent (1/72) of the carcinomas.
|
7674088 |
1995 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Adenomatous polyposis coli (APC) gene mutations occur in most sporadic colonic adenomas and carcinomas.
|
7743497 |
1995 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
APC mutation was not found in 16 de novo carcinomas or the one pyloric gland-type adenoma examined.
|
8809879 |
1996 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Additionally, we performed multiregional, targeted next-generation sequencing (NGS) of adenomas and unmasked extensive heterogeneity, affecting known drivers such as APC, KRAS and mismatch repair (MMR) genes.
|
30166531 |
2018 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
All carcinomas with 5q LOH, 5q MSI, or methylation included at least one APC mutation, whereas 5 carcinomas and 6 adenomas showed solely an APC mutation.
|
12673484 |
2003 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Alterations of APC, KRAS and TP53 were observed in a higher percentage of adenocarcinomas compared to adenomas (P<0.05) indicating that the alterations accumulated with malignancy.
|
19576232 |
2009 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Although many cases of classical familial adenomatous polyposis (> 100 polyps) can be accounted for by mutations in the adenomatous polyposis coli (APC) gene, a large group of patients remains with multiple (5-100) adenomas and in whom there is no detectable APC mutation.
|
16998667 |
2006 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
BEFREE |
An important role for beta-catenin pathways in colorectal carcinogenesis was first suggested by the protein's association with adenomatous polyposis coli (APC) protein, and by evidence of dysregulation of beta-catenin protein expression at all stages of the adenoma-carcinoma sequence.
|
11839557 |
2002 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
AXIN2 and MUTYH genes were screened for germline mutations by PCR and direct sequencing in 39 unrelated patients with multiple adenomas or colorectal cancer without evidence of APC mutation nor mismatch repair defect.
|
16941501 |
2006 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Because adenomatous polyposis coli protein has a "gatekeeper role" in the adenoma-carcinoma sequence, replacing its function may reduce polyp formation.
|
15657662 |
2004 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Because alterations of the adenomatous polyposis coli (APC) gene are present in biliary tract cancers and the APC protein modulates levels of beta-catenin, we evaluated the role of beta-catenin in biliary tract cancer by sequencing the third exon of the beta-catenin gene among 107 biliary tract cancers and 7 gallbladder adenomas from a population-based study in CHINA: Point mutations of serine or threonine phosphorylation sites in exon 3 of beta-catenin were present in 8 of 107 (7.5%) biliary tract cancers and 4 of 7 (57.1%) gallbladder adenomas.
|
11309300 |
2001 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
By employing genomic sequencing, i.e., base-specific analysis of methylated cytosines, we show here that the promoter region of the APC gene is heavily methylated at CpG sites in patients with colorectal carcinoma in comparison with normal colonic mucosa and premalignant adenomas.
|
9096643 |
1997 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Cancers in hereditary non-polyposis colorectal cancer show features of both classical (adenoma and APC mutation) and alternative pathways (rapid evolution, MSI-H and lack of chromosomal instability).
|
11987262 |
2002 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Cell cycle activity was assessed using immunohistochemistry ofthe proliferation marker Ki67, and mutation analysis was carried out for KRAS and APC to determine the involvement of the adenoma-carcinoma sequence.
|
21412070 |
2011 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Clinical features of familial adenomas polyps in Chinese and establishment of its immortal lymphocyte cell lines.
|
17569124 |
2007 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Complete loss of APC protein did not influence morphology, location, or appearance of adenomas, nor was it affected by the patient's age.
|
16804979 |
2006 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
BEFREE |
Complete loss of APC protein did not influence morphology, location, or appearance of adenomas, nor was it affected by the patient's age.
|
16804979 |
2006 |
|
Adenoma
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Cross-species comparison of human and mouse intestinal polyps reveals conserved mechanisms in adenomatous polyposis coli (APC)-driven tumorigenesis.
|
18403596 |
2008 |
|
Adenoma
|
0.400 |
Biomarker
|
group |
CTD_human |
Crypt stem cells as the cells-of-origin of intestinal cancer.
|
19092804 |
2009 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
LHGDN |
CTNNB1 mutations were found in 2/19 adenomas without APC mutation.
|
12737446 |
2003 |
|
Adenoma
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Digital SNP analysis demonstrated loss of heterozygosity of APC only in the adenoma from the twin without PMP but not from the appendiceal or peritoneal tumors of the twin with PMP.
|
11474297 |
2001 |