|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These results suggest the following mechanisms for the development of colon tumors in patients with familial adenomatous polyposis: (a) the heterozygous mutant/wild-type condition at the APC gene causes formation of mild or moderate adenoma; (b) the loss of the normal allele in the APC gene leads to a change from moderate to severe adenoma; (c) LOH on chromosome 17p contributes to the conversion of adenoma to intramucosal carcinoma; (d) LOH on other chromosomes, such as 18 and 22q, are involved in the progression of intramucosal carcinoma to invasive carcinoma; and (e) K-ras mutation may also affect the development of moderate to severe adenoma.
|
1977514 |
1990 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
We determined the genomic structure of the rat Apc gene, and we analyzed mutations in colon tumors induced in F344 rats by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f]quinoline (IQ), potent carcinogens contained in ordinary daily human food.
|
7846077 |
1995 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Only 2 of 13 IQ-induced colon tumors had mutations of the APC gene and these were base substitution mutations.
|
8608549 |
1996 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
These results indicate that the colon tumor of the TS patient carries the Ki-ras and APC gene mutations.
|
9589476 |
1998 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Neonatal exposure to the food mutagen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine via breast milk or directly induces intestinal tumors in multiple intestinal neoplasia mice.
|
10383901 |
1999 |
|
Colonic Neoplasms
|
0.600 |
PosttranslationalModification
|
group |
BEFREE |
Our results support the view that malignant progression is a consequence of more than one genetic change and suggest that inactivation of APC and DCC genes plays a role in a multistep process of colon tumor progression.
|
10090594 |
1999 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Recent evidence suggests that the beta-catenin gene (CTNNB1) acts as an oncogene, and some human colon tumors with an intact APC gene have activating mutations in CTNNB1.
|
10204808 |
1999 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Recently defined target genes are c-myc and cyclin D1, linking the APC gene defect to the capacity for autonomous proliferation of colon tumors.
|
10514384 |
1999 |
|
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Evidence that APC regulates survivin expression: a possible mechanism contributing to the stem cell origin of colon cancer.
|
11751382 |
2001 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
PhIP in the diet for >43 weeks present colon tumors with specific -1G mutations within 5'-GGGA-3' sequences of the APC: gene.
|
11181456 |
2001 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
One dose of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) or 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) induces tumours in Min/+ mice by truncation mutations or LOH in the Apc gene.
|
12034317 |
2002 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We determined the error spectrum of DNA polymerase beta in the human APC gene under PCR conditions and compared it with the set of mutations reported in human colon tumors.
|
12036944 |
2002 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
To study the role of APC in signaling ODC expression, we used the human colon tumor cell line HT29 (wtAPC-/-), which has been stably transfected with a zinc-inducible wild-type APC gene.
|
12112318 |
2002 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
The different pathways observed and their distribution can be summarized as follows: (a) K-ras mutations were more commonly detected in colon than in rectum; (b) the number of mutations detected was significantly higher in colon than in rectal tumors; and (c) a mutational pattern restricted to the APC gene was more common in rectal than in colon tumors.
|
15217933 |
2004 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
LHGDN |
Colorectal cancer prevention.
|
15375803 |
2004 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
From this descriptive study, it seems that the short-term risk for colonic polyps in I1307K APC mutation is low, primarily affecting patients with previously diagnosed colon tumors.
|
15733272 |
2005 |
|
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Tumor suppressor APC blocks DNA polymerase beta-dependent strand displacement synthesis during long patch but not short patch base excision repair and increases sensitivity to methylmethane sulfonate.
|
15548520 |
2005 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Total meat consumption was not associated with the endpoints studied.Meat product (i.e. processed meat) consumption showed a positive association with colon tumours harbouring a truncating APC mutation, whereas beef consumption was associated with an increased risk of colon tumours without a truncating APC mutation (incidence rate ratio (RR) highest versus lowest quartile of intake 1.61, 95% confidence interval (CI) 0.96-2.71, p-trend = 0.04 and 1.58, 95% CI 1.10-2.25, p-trend = 0.01, respectively).
|
16184469 |
2005 |
|
Colonic Neoplasms
|
0.600 |
AlteredExpression
|
group |
LHGDN |
Truncated APC is required for cell proliferation and DNA replication.
|
16450383 |
2006 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
LHGDN |
Examination of actin and microtubule dependent APC localisations in living mammalian cells.
|
16423286 |
2006 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The majority of colon tumors develop because of mutations in the tumor suppressor APC that lead to Wnt/beta-catenin signaling activation and subsequent transcription of target genes, including conductin/AXIN2.
|
16815967 |
2006 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Relatively high folate consumption reduced the risk of APC(-) colon tumors, but folate intake was positively associated with APC(+) colon tumors among men.
|
17116713 |
2006 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
BEFREE |
Although it is weaker than that in Apc gene-deficient mice, it may be linked to colon tumor development.
|
16478792 |
2006 |
|
Colonic Neoplasms
|
0.600 |
Biomarker
|
group |
CTD_human |
Comet fluorescence in situ hybridization analysis for oxidative stress-induced DNA damage in colon cancer relevant genes.
|
17192441 |
2007 |
|
Colonic Neoplasms
|
0.600 |
GeneticVariation
|
group |
BEFREE |
We reliably detected germline SNPs and discovered a colon tumor specific nonsense mutation in APC, a gene causally implicated in colorectal cancer.
|
18849522 |
2008 |