|
Prolactinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, Ptx2 was also expressed in pure lactotroph adenomas and not in somatotroph adenomas.
|
10372733 |
1999 |
|
Growth Hormone-Secreting Pituitary Adenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Finally, Ptx2 was also expressed in pure lactotroph adenomas and not in somatotroph adenomas.
|
10372733 |
1999 |
|
Epstein-Barr Virus Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
SAP is deficient in patients affected by X-linked lymphoproliferative disorder (XLP), which is triggered following EBV infection.
|
10658976 |
2000 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings suggest that association of SAP with 2B4 is necessary for optimal NK/lymphokine-activated killer cytotoxicity and imply that alterations in SAP/2B4 signaling contribute to the immune dysfunction observed in XLP.
|
11034354 |
2000 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
SAP is deficient in patients affected by X-linked lymphoproliferative disorder (XLP), which is triggered following EBV infection.
|
10658976 |
2000 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genomic organization and characterization of mouse SAP, the gene that is altered in X-linked lymphoproliferative disease.
|
10970095 |
2000 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
SAP mutation, and not Epstein-Barr virus infection per se, may be critical for XLP.
|
10899030 |
2000 |
|
Alzheimer's Disease
|
0.070 |
Biomarker
|
disease |
BEFREE |
Because SAP is a component of mouse serum, these findings suggest the blood-brain barrier in transgenic mice is not affected as it is in AD.
|
10818497 |
2000 |
|
Oral candidiasis
|
0.040 |
Biomarker
|
disease |
BEFREE |
Distinct SAP genes have previously been shown to contribute to tissue damage in a model of oral candidiasis.
|
10733678 |
2000 |
|
Immune System Diseases
|
0.030 |
Biomarker
|
group |
BEFREE |
These findings suggest that association of SAP with 2B4 is necessary for optimal NK/lymphokine-activated killer cytotoxicity and imply that alterations in SAP/2B4 signaling contribute to the immune dysfunction observed in XLP.
|
11034354 |
2000 |
|
Lupus Erythematosus, Systemic
|
0.030 |
Biomarker
|
disease |
BEFREE |
Complexes of serum amyloid P component and DNA in serum from healthy individuals and systemic lupus erythematosus patients.
|
11202230 |
2000 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
Role of serum amyloid P component in bacterial infection: protection of the host or protection of the pathogen.
|
11121061 |
2000 |
|
Cutaneous Candidiasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study a progressive SAP expression in the order SAP1 and SAP2 > SAP8 > SAP6 > SAP3 was observed in an in vitro model of cutaneous candidiasis based on reconstituted human epidermis.
|
10733678 |
2000 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two out of three have disease-causing mutations in the SAP gene, consistent with published data for XLP.
|
11678908 |
2001 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Distinct interactions of the X-linked lymphoproliferative syndrome gene product SAP with cytoplasmic domains of members of the CD2 receptor family.
|
11414741 |
2001 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have introduced a targeted mutation in SH2D1A/DSHP/SAP, the gene responsible for the human genetic disorder X-linked lymphoproliferative disease (XLP).
|
11404475 |
2001 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Cell surface receptors Ly-9 and CD84 recruit the X-linked lymphoproliferative disease gene product SAP.
|
11389028 |
2001 |
|
Plaque, Amyloid
|
0.040 |
Biomarker
|
disease |
BEFREE |
His outcome was followed clinically and his amyloid deposits were monitored with serum amyloid P component scintigraphy.
|
11349736 |
2001 |
|
Acute Megakaryocytic Leukemias
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
|
11431691 |
2001 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several years ago, the gene defective in XLP was identified as SAP (SLAM-associated protein), and recent data suggest that SAP plays a broad role in immune signaling.
|
12165201 |
2002 |
|
X-Linked Lymphoproliferative Disorder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells.
|
12008045 |
2002 |
|
Burkitt Lymphoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We studied SAP expression in several Burkitt lymphoma (BL) derived lines.
|
12008045 |
2002 |
|
Adult Burkitt Lymphoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We studied SAP expression in several Burkitt lymphoma (BL) derived lines.
|
12008045 |
2002 |
|
Childhood Burkitt Lymphoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
We studied SAP expression in several Burkitt lymphoma (BL) derived lines.
|
12008045 |
2002 |
|
Bacterial Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
In marked contrast to the dramatic effects of SAP deficiency on host resistance to different bacterial infections, mouse SAP apparently plays no significant role during infection of mice with influenza virus.
|
11984001 |
2002 |