|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, the authors suggest that the cooperative effects of Ha-ras and fes oncogenes are especially important in the carcinogenesis of adenocarcinoma.
|
1310887 |
1992 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
If a mutation of c-K-ras 2 gene is an important component in the formation of adenocarcinoma, these results did not confirm the successive development from adenomas with severe atypia to advanced carcinomas as the main route for colorectal carcinogenesis in familial adenomatous polyposis patients.
|
1333425 |
1992 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutant c-K-ras genes were detected in about 75% of adenocarcinomas of the pancreas (n = 84); 40% of adenomas (n = 72) and carcinomas (n = 244) of the colon end rectum; 30% of carcinomas of the bile duct (n = 19); 25% of carcinomas of the lung (n = 92), and in lower frequency in other carcinomas, including liver, stomach, and kidney.
|
1685441 |
1991 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutant c-K-ras genes were found at the time of initial clinical presentation in the majority of pancreatic adenocarcinomas, suggesting an important role of the mutation in oncogenesis.
|
2404591 |
1990 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The frequency of Ki-ras gene mutations was studied in 100 paraffin-embedded sections obtained from 63 pancreatic adenocarcinomas by in vitro amplification of target sequences via polymerase chain reaction (PCR) and selective oligonucleotide hybridization.
|
2659539 |
1989 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Direct sequencing analysis of exon 1 of the c-K-ras gene shows a low frequency of mutations in human pancreatic adenocarcinomas.
|
2674856 |
1989 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
To determine whether the molecular lesion in ovarian carcinoma was a genetic rearrangement or amplification of expressed oncogenes, we examined the myc, Ha-ras, Ki-ras, and fos oncogenes in 14 serous adenocarcinomas of the ovary using molecular hybridization techniques.
|
2801838 |
1989 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The c-Ki-ras gene was hypomethylated to a lesser extent in two colonic adenocarcinomas.
|
6187346 |
1983 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Eight of 22 prostate adenocarcinomas (three of nine (33.3%) from the ventral lobe and five of 13 (38.5%) from the dorsolateral lobe, including three transplantable tumors) and one of 11 seminal vesicle adenocarcinomas (9.1%) demonstrated point mutations in the Ki-ras gene.
|
7766307 |
1995 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the 16 samples adequate for PCR/RFLP analysis, a c-Ki-ras gene mutation was detected in 11 (92%) of 12 adenocarcinomas.
|
7902444 |
1993 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In addition, point mutations of the c-Ki-ras gene were detected in 1 gastric-type adenocarcinoma and 2 intestinal-type adenocarcinomas, suggesting the occurrence of a common genetic abnormality.
|
7903667 |
1993 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung.
|
7910096 |
1994 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
HPV DNA type 16 or 18 in cervical adenocarcinomas was detected in 35% of cases by PCR and in 29% by Southern blotting, and, in contrast to the p53 mutations, the majority of cases with the HPV DNA were at a relatively early clinical stage with low-grade histological atypia. c-Ki-ras gene mutation was detected in only 4% of cervical adenocarcinomas.
|
7960232 |
1994 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Seventy-seven pancreatic adenocarcinomas (60 Spanish and 17 Italian) were tested for Ki-ras gene mutations by analysis of polymerase chain reaction amplified sequences.
|
8157353 |
1994 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Eight pancreatic adenocarcinomas in the range 1.2-3 cm were analyzed for c-K-ras mutation at codon 12 by amplifying the c-K-ras gene around codon 12 out of paraffin-embedded tissue sections using the polymerase chain reaction. c-K-ras mutations were detected by allele-specific oligonucleotide hybridization.
|
8190717 |
1994 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
One hundred ninety-four consecutive primary, recurrent, and metastatic colorectal adenocarcinomas, accessioned during 1991 at Rhode Island Hospital, were classified according to the presence and specific type of K-ras-2 point mutation.
|
8508351 |
1993 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings provide the first evidence for amplification of the Ki-ras gene in human esophageal cancer, which is restricted to adenocarcinomas.
|
8519418 |
1995 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Adenocarcinomas from the left side of the colorectum showed a significant association between C-KI-RAS activation and tumour progression, including the presence of distant organ metastasis at the time of surgery (P = 0.0039), and during patient follow-up (P = 0.00027), whereas those from the right of the colorectum did not (P = 0.4 and P = 0.5, respectively).
|
8814697 |
1996 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Topographic genotyping with subsequent polymerase chain reaction (PCR) and sequence analysis of K-ras-2 showed mutations in significantly fewer cases of PC (9%, 2 of 22 cases) than in AdC (36%, 35 of 97 cases) or SqC (0%, 0 of 42 cases) (P < .001).
|
8853037 |
1996 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Ki-ras gene mutation was detected in 12 of 20 (60%) mucin-producing adenocarcinomas.
|
9234384 |
1997 |
|
Adenocarcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Amplification of KRAS2 was detected in two adenocarcinomas by Southern blot analysis.
|
9460997 |
1998 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Meanwhile, 11 (58 per cent) serrated adenomas and six (60 per cent) adenocarcinomas in/with serrated adenomas had Ki-ras gene mutations, as also did 9 of 23 (39 per cent) hyperplastic nodules, 3 of 4 (75 per cent) hyperplastic polyps, and 12 of 29 (41 per cent) tubular adenomas.
|
9924427 |
1998 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the other tumors, more complex aberrations were visualized, including two inversions in 12q with a common breakpoint between MDM2 and D12S332 in a pleomorphic adenoma, amplification of MDM2 and CDK4 in ring chromosomes from a malignant fibrous histiocytoma, and amplification of KRAS2 together with other unbalanced rearrangements in two pancreatic adenocarcinomas.
|
10862042 |
2000 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mutations in k-ras-2 were seen in 25% and 19% of RC and NRC tumors, respectively, most frequently in adenocarcinomas.
|
12527710 |
2003 |
|
Adenocarcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we report that loss of heterozygosity (LOH) of chromosome 12p was detected in approximately 50% of human lung adenocarcinomas and large cell carcinomas, and Kras2 mutations were detected at codon 12 in approximately 40% of adenocarcinomas and large cell carcinomas.
|
12606951 |
2003 |