Hypertensive disease
|
0.700 |
Biomarker
|
group |
HPO |
|
|
|
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of human hypertension thought to result from a deficiency of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD).
|
7670488 |
1995 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of human hypertension thought to result from a deficiency of 11 beta-hydroxysteroid dehydrogenase (11 beta HSD).
|
7670488 |
1995 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
Furthermore, in the rat, an association between placental 11 beta HSD activity and the subsequent development of hypertension in the offspring has been reported.
|
7883847 |
1995 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME is due to a mutation in the 11 beta-HSD2 gene, and is an example of human hypertension arising from a single gene defect.
|
8538347 |
1996 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Our data suggest that HSD11B2 is associated with hypertension in our black subjects with hypertensive end-stage renal disease.
|
8794836 |
1996 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the HSD11K (HSD11B2) gene encoding this isozyme cause a genetic form of hypertension, the syndrome of apparent mineralocorticoid excess (AME).
|
8865170 |
1996 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The syndrome of apparent mineralocorticoid excess (AME) is an inherited form of hypertension in which 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) is defective.
|
8979285 |
1997 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
The syndrome of AME is a rare form of juvenile hypertension in which 11-HSD is defective.
|
9034789 |
1997 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations generating inactive enzymes have been described in the HSD11B2 gene in the congenital syndrome of apparent mineralocorticoid excess (AME)--a low renin form of hypertension.
|
9247735 |
1997 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations of the gene encoding 11beta-HSD-2 are responsible for the syndrome of apparent mineralocorticoid excess, in which cortisol illicitly occupies mineralocorticoid receptors, causing hypertension and hypokalaemia.
|
9370341 |
1997 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
AME represents a spectrum of mineralocorticoid hypertension with severity reflecting the underlying genetic defect in the 11beta-HSD2 gene; classification into distinct subtypes is inappropriate.
|
9683587 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
11 beta-HSD2 activity is not decreased in glucocorticoid hypertension (Cushing's syndrome).
|
9683905 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Recently, we have studied an unusual patient with mild low-renin hypertension and a homozygous mutation in the HSD11B2 gene.
|
9707624 |
1998 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Recently, we have studied an unusual patient with mild low-renin hypertension and a homozygous mutation in the HSD11B2 gene.
|
9707624 |
1998 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Statistical analyses using the affected sib-pair method did not show significant linkage between the 11beta-HSD2 microsatellite marker and hypertension.
|
9856363 |
1998 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
In congenital 11beta-HSD deficiency and after administration of 11beta-HSD inhibitors, suppression of 11beta-HSD2 activity in the kidney has been believed to cause renal mineralocorticoid excess, resulting in sodium retention and hypertension.
|
10334808 |
1999 |
Hypertensive disease
|
0.700 |
AlteredExpression
|
group |
BEFREE |
These results reveal that cholic acid is able to induce hypertension and provide evidence that cholic acid inhibits the transcription of both 11beta-HSD2 and CYP11B2 in vasculature, leading to lower aldosterone and higher corticosterone production in vessels and increased vasoconstrictor responses to norepinephrine.
|
10399886 |
1999 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Thus, depending on the degree of loss of enzyme activity, 11 beta HSD2 mutations can cause a spectrum of phenotypes ranging from severe, life-threatening hypertension in infancy to a milder form of the disease in adults.
|
10726708 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
A genetic association of a microsatellite flanking the HSD11B2 gene and hypertension in black patients with end-stage renal disease has been reported.
|
10760070 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
RGD |
In the development of diabetes-induced hypertension, the effect of spironolactone on mean systolic blood pressure may be associated with the mineralocorticoid effects of corticosterone on renal MR, as well as an alteration of renal 11beta-HSD2 activity and its mRNA expression in insulin-dependent diabetic rats.
|
10792625 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
BEFREE |
Because the hypertension associated with AME is of the salt-sensitive type, it seemed possible that decreases in 11-HSD2 activity might be associated with salt sensitivity.
|
10948076 |
2000 |
Hypertensive disease
|
0.700 |
Biomarker
|
group |
CTD_human |
Functional adrenocorticotropic hormone receptor in cultured human vascular endothelial cells : possible role in control of blood pressure.
|
11082157 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Because polymorphisms in HSD11B2 have been associated with hypertension and salt sensitivity, we characterized the human VPATPD gene.It spans 19 kb and consists of 8 exons.
|
11118322 |
2000 |
Hypertensive disease
|
0.700 |
GeneticVariation
|
group |
BEFREE |
Mutations in the HSD11B2 gene encoding the kidney (11-HSD2) isozyme of 11beta-hydroxysteroid dehydrogenase cause the syndrome of apparent mineralocorticoid excess, a form of salt-sensitive hypertension.
|
11196453 |
2000 |