BIRC5, baculoviral IAP repeat containing 5, 332

N. diseases: 199; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.390 Therapeutic group CTD_human Cisplatin activates Akt in small cell lung cancer cells and attenuates apoptosis by survivin upregulation. 15981204 2005
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.390 GeneticVariation group LHGDN Polymorphisms in the survivin gene and the risk of lung cancer. 17961802 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN Increased expression of survivin in gastric cancer patients and in first degree relatives. 12085263 2002
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN Chemoresponse to docetaxel correlates with expression of the survivin splicing variants in patients with gastric cancer. 18251132 2008
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN Expression of survivin mRNA and protein in gastric cancer cell line (MKN-45) during cisplatin treatment. 11773702 2002
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN Expression of survivin and caspase-3 in gastric cancer. 12643601 2003
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 Biomarker group CTD_human Rebamipide inhibits gastric cancer growth by targeting survivin and Aurora-B. 15993841 2005
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN STAT3 is constitutively activated and supports cell survival in association with survivin expression in gastric cancer cells. 15077160 2004
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 AlteredExpression group LHGDN Significance of Survivin and PTEN expression in full lymph node-examined gastric cancer. 16534839 2006
CUI: C0038356
Disease: Stomach Neoplasms
Stomach Neoplasms
0.370 Biomarker group LHGDN Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection. 15457550 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 Biomarker group CTD_human PIAS3, SHP2 and SOCS3 Expression patterns in Cervical Cancers: Relevance with activation and resveratrol-caused inactivation of STAT3 signaling. 26432044 2015
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 AlteredExpression group LHGDN Inhibition of survivin reduces cell proliferation and induces apoptosis in human endometrial cancer. 16826583 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 AlteredExpression group LHGDN Survivin in esophageal cancer: An accurate prognostic marker for squamous cell carcinoma but not adenocarcinoma. 16671090 2006
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 Biomarker group BEFREE Then, using BIRC5 as a candidate, the prognostic value in LAD and TN adenocarcinomas was verified by the Kaplan-Meier plotter and The Cancer Genome Atlas (TCGA) database, respectively. 31093306 2019
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 AlteredExpression group BEFREE The positive rate of EPR-1 expression in the primary gastric adenocarcinomas, invasion tumor node and lymph node metastasis was 65.83%, 55.29% and 68%, respectively. 15112339 2004
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 AlteredExpression group BEFREE Specifically, we found that BIRC5, which codes for survivin, is upregulated in both adenocarcinoma and squamous cell carcinoma tissues and that high expression of BIRC5 is associated with poor survival in adenocarcinoma, but not squamous cell carcinoma. 29416000 2018
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma
0.360 AlteredExpression group LHGDN Comparative study of various biological parameters, including expression of survivin, between primary and metastatic human colonic adenocarcinomas. 12168867 2002
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 Biomarker group CTD_human Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. 16364925 2006
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 AlteredExpression group LHGDN Cell-cycle and apoptosis regulators (p16INK4A, p21CIP1, beta-catenin, survivin, and hTERT) and morphometry-defined MPECs predict metachronous cancer development in colorectal adenoma patients. 17641414 2007
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 Biomarker group LHGDN T-cell responses to survivin in cancer patients undergoing radiation therapy. 18676762 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 AlteredExpression group LHGDN Suppression of colorectal tumor growth by regulated survivin targeting. 17077982 2006
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 AlteredExpression group LHGDN Detection of survivin-expressing circulating cancer cells (CCCs) in peripheral blood of patients with gastric and colorectal cancer reveals high risks of relapse. 18670822 2008
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 AlteredExpression group LHGDN Correlation between transcriptional expression of survivin isoforms and clinicopathological findings in human colorectal carcinomas. 15809755 2005
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms
0.360 Biomarker group LHGDN Spontaneous and radiation-induced apoptosis in colorectal carcinoma cells with different intrinsic radiosensitivities: survivin as a radioresistance factor. 12654446 2003
CUI: C0009375
Disease: Colonic Neoplasms
Colonic Neoplasms
0.340 GeneticVariation group LHGDN Gene therapy for colon cancer by adeno-associated viral vector-mediated transfer of survivin Cys84Ala mutant. 15685548 2005