Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
The amyloid precursor-like protein-1 (APLP1) is a member of a protein family that includes the Alzheimer's disease-associated amyloid precursor protein (APP).
|
19401174 |
2009 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Amyloid-precursor-like protein 1 (APLP1) is a membrane-associated glycoprotein, whose gene is homologous to the APP gene, which has been shown to be involved in the pathogenesis of Alzheimer's disease.
|
9521588 |
1998 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Consistently, knockdown or antagonization of DOR reduces secretase activities and ameliorates Abeta pathology and Abeta-dependent behavioral deficits, but does not affect the processing of Notch, N-cadherin or APLP in AD model mice.
|
20066010 |
2010 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our results suggest that even though APLP1 and APLP2 cannot generate Abeta, they may potentially contribute to the pathology of AD by generating peptide fragments whose toxicity is comparable to that of APPC31.
|
12124429 |
2002 |
Alzheimer's Disease
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Taken together, the direct cleavage of APLP1 is a novel feature of the γ-secretase prompting a re-thinking of γ-secretase activity modulation as a therapeutic strategy for Alzheimer disease.
|
29382944 |
2018 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
Presence of a "CAGA box" in the APP gene unique to amyloid plaque-forming species and absent in all APLP-1/2 genes: implications in Alzheimer's disease.
|
15208260 |
2004 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
CSF APLP1 was not different between any of the AD severity groups (p = 0.31).
|
31415236 |
2019 |
Alzheimer's Disease
|
0.080 |
Biomarker
|
disease |
BEFREE |
In conclusion, our results establish that APLPs show typical features of SAMs and indicate that increased surface expression, as observed for APLP1, is essential for proper synapse formation <i>in vitro</i> and synapse maintenance <i>in vivo</i><b>SIGNIFICANCE STATEMENT</b> According to the amyloid-cascade hypothesis, Alzheimer's disease is caused by the accumulation of Aβ peptides derived from sequential cleavage of the amyloid precursor protein (APP) by β-site APP cleaving enzyme 1 (BACE1) and γ-secretase.
|
28450540 |
2017 |
Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.
|
14597230 |
2003 |
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |
Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Central neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |
Central neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.
|
14597230 |
2003 |
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Increased gene expression of beta-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid.
|
9121703 |
1997 |
Childhood Neuroblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Amyloid-beta precursor-like protein APLP1 is a novel p53 transcriptional target gene that augments neuroblastoma cell death upon genotoxic stress.
|
17533371 |
2007 |
Childhood Neuroblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Accumulation of the amyloid precursor-like protein APLP2 and reduction of APLP1 in retinoic acid-differentiated human neuroblastoma cells upon curcumin-induced neurite retraction.
|
14597230 |
2003 |
Familial Alzheimer Disease (FAD)
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid precursor-like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late-onset FAD.
|
8220435 |
1993 |
Familial Alzheimer Disease (FAD)
|
0.020 |
Biomarker
|
disease |
BEFREE |
A late onset FAD locus has been mapped to a region of chromosome 19 in which a recently isolated APP-like gene, APLP1 has also been localized, making this gene a strong candidate to harbor a late-onset FAD defect.
|
8239284 |
1993 |
Amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Because of its location and the proposed interference of amyloid with basement membrane assembly, APLP1 has been considered a candidate gene for CNF.
|
9521588 |
1998 |
Carcinoid Tumor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We conclude that APLP1 is differentially upregulated in gastrointestinal NE tumours and that APLP1 may be important for the dissemination of small intestinal carcinoids.
|
18430897 |
2008 |
Epilepsy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, pilocarpine induced a significant down-regulation of APLP1 mRNA expression at 6 h after epilepsy initiation (P< 0.05), and at 30 h, this down-regulation became more dramatic (P< 0.01), which lasted till day 15 (P< 0.01).
|
19448684 |
2009 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination.
|
18430897 |
2008 |
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Quantitative real-time PCR and western blot analysis demonstrated higher expression of APLP1 in carcinoid metastases relative to primary tumours indicating a role of APLP1 in tumour dissemination.
|
18430897 |
2008 |
Neuroendocrine Tumors
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Amyloid precursor-like protein 1 is differentially upregulated in neuroendocrine tumours of the gastrointestinal tract.
|
18430897 |
2008 |