|
Malignant neoplasm of larynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The investigation of hyaluronic acid and hyaluronidase-1 levels as tumour marker in larynx cancer.
|
31207115 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study suggests that HYAL1 and HYAL2 suppress CRC metastasis through regulating MMPs/TIMPs balance and rearranging F-actin distribution, further inhibiting invasion and migration of cancer cells.
|
30972813 |
2019 |
|
Chronic Obstructive Airway Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL-1 enzymatic activity at stable state was inversely correlated with FEV<sub>1</sub> % pred (p=0.034) and survival time (p=0.017).Serum HA is associated with COPD severity and predicts overall survival.
|
30705130 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
aPSCs are an important source of stromal HMW-HA, which promotes PCC migration in an HYAL1-dependent manner in PC.
|
31171359 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
aPSCs are an important source of stromal HMW-HA, which promotes PCC migration in an HYAL1-dependent manner in PC.
|
31171359 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The suppressive role of HYAL1 and HYAL2 in the metastasis of colorectal cancer.
|
30972813 |
2019 |
|
Secondary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL1 expression in brain metastases was also significantly lower than in skin, liver, and lung metastases.
|
28168629 |
2017 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
HYAL1 expression in brain metastases was also significantly lower than in skin, liver, and lung metastases.
|
28168629 |
2017 |
|
Nasal Polyps
|
0.010 |
Biomarker
|
disease |
BEFREE |
On mRNA level, it was found that hyal-1-wt was decreased in NPs compared to NM and hyal-1-v3, -v4 and -v5 were substantially increased.
|
26661071 |
2016 |
|
Allergic sensitization
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, induction of HYAL1 expression concurrent with antigen exposure accelerated allergic sensitization.
|
24487587 |
2014 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
HYAL1 mRNA was absent in all specimens, whereas HYAL2 was expressed as two splice variants, of which HYAL2-var2 was overexpressed in solid metastases compared to effusions and primary carcinomas (p < 0.001).
|
23202930 |
2012 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Although HYAL-1 is a critical determinant of tumor progression and a marker for cancer diagnosis and metastasis prediction, it has not been evaluated as a target for cancer therapy.
|
21555367 |
2011 |
|
Epithelial ovarian cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Concordantly, HYAL1 mRNA levels and enzymatic activity were elevated only in EOC cell lines derived from clear cell and mucinous subtypes.
|
21695196 |
2011 |
|
Familial (FPAH)
|
0.010 |
Biomarker
|
disease |
BEFREE |
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
|
21559944 |
2011 |
|
Juvenile arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
|
21559944 |
2011 |
|
Juvenile rheumatoid arthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A complete deficiency of Hyaluronoglucosaminidase 1 (HYAL1) presenting as familial juvenile idiopathic arthritis.
|
21559944 |
2011 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Concordantly, HYAL1 mRNA levels and enzymatic activity were elevated only in EOC cell lines derived from clear cell and mucinous subtypes.
|
21695196 |
2011 |
|
Lung Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
[Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer].
|
19140316 |
2009 |
|
Lysosomal Storage Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Mutations in one of these genes cause a deficiency of hyaluronidase 1 (HYAL1) resulting in a lysosomal storage disorder, mucopolysaccharidosis (MPS) IX.
|
18344557 |
2008 |
|
Invasive Prostate Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively results also imply that HA processing by elevated HYAL1 expression in invasive prostate cancer is a requirement for progression.
|
17502371 |
2007 |
|
Metastatic Prostate Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hyal1 is implicated as an inducer of prostate cancer metastatic progression.
|
17003496 |
2006 |
|
Mucopolysaccharidosis IV
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Normal levels of serum Hyal-1 activities were found in patients with Morquio disease, GM1 gangliosidosis, I cell-disease, 6 of the 7 patients with achondroplasia, Marfan's-syndrome and Ehlers-Danlos syndrome.
|
16311883 |
2005 |
|
Endometrial Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Real-time RT-PCR was used to determine the mRNA expression of Hyal 1, Hyal 2 (n = 13) and Hyal 3 (n = 11) in endometrial carcinomas.
|
15936804 |
2005 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
In a panel of SCLC and glioma cell lines the expression of HYAL1, HYAL2 and HYAL3 mRNA was examined.
|
12684632 |
2003 |
|
Glioma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In a panel of SCLC and glioma cell lines the expression of HYAL1, HYAL2 and HYAL3 mRNA was examined.
|
12684632 |
2003 |