|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, a species-specific structural motif in the putative amyloidogenic region of IAPP is associated with both amyloid formation and the development of age-related diabetes mellitus.
|
2670595 |
1989 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Amylin and the amylin gene: structure, function and relationship to islet amyloid and to diabetes mellitus.
|
2690958 |
1989 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The connection between IAPP amyloid formation and diabetes is unknown, but a limited segment of the IAPP molecule, positions 20-29, seems responsible for the aggregation to fibrils.
|
2195544 |
1990 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Is islet amyloid polypeptide a significant factor in pathogenesis or pathophysiology of diabetes?
|
1999269 |
1991 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Islet amyloid polypeptide: mechanisms of amyloidogenesis in the pancreatic islets and potential roles in diabetes mellitus.
|
1573849 |
1992 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of IAPP and IA in the pathogenesis of human NIDDM and similar forms of diabetes mellitus in cats and macaques may involve several possible mechanisms, including 1) direct physical/chemical damage to beta-cells, resulting in necrosis and loss of functional islet tissue, 2) biologic activities of IAPP that oppose those of insulin or abnormally suppress insulin secretion, and 3) interference by IA deposits of passage of insulin out of beta-cells and/or entrance of glucose and other secretogogues into the islet.
|
8212454 |
1993 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Plasma IAPP concentrations were elevated in the patients with pancreatic cancer as compared with the normal subjects (mean [+/- SD], 22.3 +/- 13.6 vs. 8.0 +/- 5.0 pmol per liter; P < 0.001), normal in the patients with other cancers, and normal or low in the patients with diabetes.
|
8277951 |
1994 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Elevated plasma islet amyloid polypeptide levels have been demonstrated in some diabetic, glucose-intolerant, and obese individuals, as well as in rodent models of diabetes and obesity.
|
7929617 |
1994 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
However, IAPP derived amyloid deposits were found in only a minority of islets at approximately 20 weeks of age, notably after development of diabetes mellitus in male transgenic mice.
|
8692984 |
1996 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Islet amyloid-associated diabetes in obese A(vy)/a mice expressing human islet amyloid polypeptide.
|
9588445 |
1998 |
|
Diabetes Mellitus
|
0.100 |
GeneticVariation
|
group |
BEFREE |
S20G mutation of the amylin gene is associated with Type II diabetes in Japanese. Study Group of Comprehensive Analysis of Genetic Factors in Diabetes Mellitus.
|
11508277 |
2001 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Estrogen can prevent or reverse obesity and diabetes in mice expressing human islet amyloid polypeptide.
|
12086946 |
2002 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes.
|
15161755 |
2004 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that IAPP-induced beta-cell apoptosis causes defects in insulin secretion and beta-cell mass that lead first to hepatic insulin resistance and IFG and then to extrahepatic insulin resistance, hyperglucagonemia, and diabetes.
|
16804082 |
2006 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Rodent IAPP is not amyloidogenic, thus commonly used rodent models of diabetes do not recapitulate islet pathology in humans.
|
16804197 |
2006 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
LHGDN |
Copper-mediated formation of hydrogen peroxide from the amylin peptide: a novel mechanism for degeneration of islet cells in type-2 diabetes mellitus?
|
17617411 |
2007 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Overexpression of fibrillogenic human amylin in these human amylin transgenic mice caused beta-cell degeneration and diabetes through mechanisms independent from both peripheral insulin resistance and islet amyloid.
|
18633116 |
2008 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
We transplanted a streptozotocin-induced mouse model of diabetes with 100 islets from human IAPP (which encodes islet amyloid polypeptide) transgenic mice that have the propensity to form islet amyloid (n = 8-12) or from non-transgenic mice that do not develop amyloid (n = 6-10) in sets of studies that lasted 1 or 6 weeks.
|
19002432 |
2009 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
One hypothesis is that the link between DM and AD is related to the function of insulin-degrading enzyme (IDE), an enzyme that degrades not only insulin and pancreatic amylin but also beta-amyloid (Abeta).
|
18346114 |
2009 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Tetracycline treatment retards the onset and slows the progression of diabetes in human amylin/islet amyloid polypeptide transgenic mice.
|
19794060 |
2010 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Intriguingly, amylin deposition was also detected in blood vessels and brain parenchyma of patients with late onset AD without clinically apparent diabetes.
|
23794448 |
2013 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Islet amyloid polypeptide and diabetes.
|
23745697 |
2013 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
Analogs of IAPP have been approved for the treatment of diabetes and are under investigation for the treatment of obesity.
|
23337872 |
2013 |
|
Diabetes Mellitus
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mice hemizygous for transgenic expression of human IAPP did not develop diabetes; however, loss of β cell-specific autophagy in these animals induced diabetes, which was attributable to accumulation of toxic human IAPP oligomers and loss of β cell mass.
|
25036708 |
2014 |
|
Diabetes Mellitus
|
0.100 |
Biomarker
|
group |
BEFREE |
This short review provides a brief introduction to amylin biology, the use of an amylin analog to treat diabetes, and consideration of whether amylin could have any role in headache disorders.
|
28485843 |
2017 |