APOB, apolipoprotein B, 338

N. diseases: 339; N. variants: 122
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Hypervariability in a minisatellite 3' of the apolipoprotein B gene in patients with coronary heart disease compared with normal controls. 2351870 1990
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Lack of association between the apolipoprotein B gene 3' hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease. 1732399 1992
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE The aim of this study was to detect mutations in the genes coding for the low-density lipoprotein receptor and apolipoprotein B in patients of Southeast Asian origin with clinically diagnosed familial hypercholesterolemia (FH) and to relate these findings with the observed lower incidence of coronary heart disease in this part of the world. 11005141 2000
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Polymorphisms of the apolipoprotein B 3' variable number of tandem repeats region associated with coronary artery disease in Taiwanese. 9585673 1998
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE Individuals identified at metabolic risk should undergo 10-year global risk assessment for ASCVD or coronary heart disease to determine targets of therapy for reduction of apolipoprotein B-containing lipoproteins. 31365087 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease HPO
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Polymorphisms in the apolipoprotein B (apoB) gene have been reported to be associated with coronary heart disease (CHD). 26537298 2015
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Genetic variations of the apolipoprotein B gene in Turkish patients with coronary artery disease. 16316917 2006
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE Lipid parameters and apolipoprotein B RFLP studies: comparison of normal and coronary heart disease groups as defined by angiography. 1362695 1992
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE Low density lipoprotein cholesterol/apolipoprotein B-100 ratio: interaction of family history of premature atherosclerotic coronary artery disease with race and gender in 7 to 11 year olds. 7936858 1994
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Apolipoprotein B gene polymorphisms, lipoproteins and coronary atherosclerosis: a study of young myocardial infarction survivors and healthy population-based individuals. 1352974 1992
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Genetic variation of the apolipoprotein B gene in Korean patients with coronary artery disease. 9339897 1997
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Polymorphisms of apolipoprotein B gene in relation to coronary heart disease in Chinese Han nationality. 7910546 1994
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE Apolipoprotein B correlates with intra-plaque necrotic core volume in stable coronary artery disease. 30779793 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Elevated plasma levels of apolipoprotein B (apoB)-containing lipoproteins constitute a major risk factor for the development of coronary heart disease. 8533758 1995
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Associations of genotypes at the apolipoprotein AI-CIII-AIV, apolipoprotein B and lipoprotein lipase gene loci with coronary atherosclerosis and high density lipoprotein subclasses. 7834891 1994
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE 5' ins/del and 3' VNTR polymorphisms in the apolipoprotein B gene in relation to lipids and coronary artery disease. 18254714 2008
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE We have investigated the frequency of Hind III DNA polymorphism of the human apolipoprotein B gene in a Canadian Caucasian population with coronary artery disease, as documented by angiography, and a healthy control population. 1477972 1992
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 Biomarker disease BEFREE Serum triglyceride, high-density lipoprotein cholesterol, apolipoprotein B, and coronary heart disease in a Chinese population undergoing coronary angiography. 28506386 2017
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Angiotensin-converting enzyme and apolipoprotein B polymorphisms in coronary artery disease. 10781757 2000
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE By direct comparison of the Lp(a) and apoB plasma concentrations in 28 affected and 31 unaffected members of seven families carrying the FH trait and without history of coronary artery disease, we reached the conclusion that LDL receptor activity is not a major determinant of the Lp(a) plasma levels in these subjects. 8187228 1994
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Integrated role of two apoliprotein E polymorphisms on apolipoprotein B levels and coronary artery disease in a biethnic population. 20715976 2010
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE We have examined DNA polymorphisms associated with the apolipoprotein B gene in 95 Sri Lankan males with ischaemic heart disease and 95 matched controls. 1674237 1991
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease. 30939045 2019
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis
0.200 GeneticVariation disease BEFREE Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels that is associated with mutations in the genes LDLR (encoding low-density lipoprotein receptor) or APOB (encoding apolipoprotein B). 12730697 2003