|
Lupus Erythematosus, Systemic
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association analysis in the UK dataset and subsequent meta-analysis with the published data identified five SLE susceptibility genes reaching genome-wide levels of significance (P(comb)<5×10(-8)): NCF2 (P(comb) = 2.87×10(-11)), IKZF1 (P(comb) = 2.33×10(-9)), IRF8 (P(comb) = 1.24×10(-8)), IFIH1 (P(comb) = 1.63×10(-8)), and TYK2 (P(comb) = 3.88×10(-8)).
|
22046141 |
2011 |
|
Mucocutaneous Lymph Node Syndrome
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
|
22446961 |
2012 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Using this novel approach, we determined the methylation status of several established and candidate tumor suppressor genes and identified the ICSBP gene, encoding the myeloid and B-cell-specific transcription factor interferon consensus sequence-binding protein, as a target for aberrant hypermethylation in acute myeloid leukemia.
|
16822855 |
2006 |
|
Oral Ulcer
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci.
|
30837455 |
2019 |
|
Neutrophil count (procedure)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Monocyte count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic variation associated with circulating monocyte count in the eMERGE Network.
|
23314186 |
2013 |
|
Monocyte count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Blood basophil count (lab test)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Erectile dysfunction
|
0.100 |
GeneticVariation
|
disease |
GWASDB |
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.
|
22704111 |
2012 |
|
Monocyte count result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Monocyte count result
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genetic variation associated with circulating monocyte count in the eMERGE Network.
|
23314186 |
2013 |
|
Small Lymphocytic Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
|
24292274 |
2014 |
|
Small Lymphocytic Lymphoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.
|
21131588 |
2011 |
|
Granulocyte count
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Chronic myeloproliferative disorder
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Surviving irf8 mutants quickly developed a myeloproliferative neoplasm (MPN)-like disease with enhanced output of the myeloid precursors, which recurred after transplantation.
|
28626217 |
2018 |
|
Leukemia, Myelocytic, Acute
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In adult myeloid leukemias we found significant associations between the variant allele of PML_rs9479 and decreased AML risk (OR = 0.61 (0.38-0.97), and between variant alleles of IRF8_ rs10514611 and ARHGAP26_rs187729 and increased CML risk (OR = 2.4 (1.12-5.15) and 1.63 (1.07-2.47), respectively).
|
24886876 |
2014 |
|
Behcet Syndrome
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Two SNPs near IRF8 were associated with BD (for rs17445836 GG genotype, Pc = 9.56 × 10(-8), OR = 2.044; for rs11642873 AA genotype, Pc = 9.24 × 10(-7), OR = 1.776).
|
26794091 |
2016 |
|
Mycobacterium Infections
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Moreover, IRF-8⁻/⁻ mice, relying on a common human and mouse genetic mutation linked to susceptibility/severity of mycobacterial diseases, represent a valuable model of acute TB for comparative studies with chronically-infected congenic WT-B6 for dissecting protective and pathological immune reactions.
|
23717393 |
2013 |
|
Arteriosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IRF8 deletion in DCs significantly reduces the development of atherosclerosis, predominantly in the aortic sinus, despite a modest increase in total plasma cholesterol levels.
|
29436389 |
2018 |
|
Atherosclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
IRF8 deletion in DCs significantly reduces the development of atherosclerosis, predominantly in the aortic sinus, despite a modest increase in total plasma cholesterol levels.
|
29436389 |
2018 |
|
Crohn Disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We find associations with the IRF8 region and the region containing CDH1 and CDH3, as well as substantial phenotypic and genetic heterogeneity for CD itself.
|
22152681 |
2011 |
|
Lymphoma, Non-Hodgkin
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Mapping of the IRF8 gene identifies a 3'UTR variant associated with risk of chronic lymphocytic leukemia but not other common non-Hodgkin lymphoma subtypes.
|
23307532 |
2013 |
|
Systemic Scleroderma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
An analysis of pleiotropic genes identified two new susceptibility genes for SSc (NF-κB and PLCL2) and confirmed the IRF8 locus.
|
25880423 |
2015 |
|
Systemic Scleroderma
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We also observed associations between SSc and rs6932056 in TNFAIP3 and rs2280381 in IRF8 (P = 0.0000095 and P = 0.0030, respectively), both of which displayed associations with SSc in a European population.
|
23124809 |
2013 |