|
Monosomy
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Patients diagnosed with iris, ciliary body or choroidal melanoma with high-risk tumour cytogenetics (monosomy 3) were offered adjuvant treatment with low-dose DTIC and IFN-α-2b following primary therapy.
|
31371315 |
2020 |
|
Respiratory Tract Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
A widespread statistically significant decline of multiple pro-inflammatory parameters and cytokines were detected in the recovery period after respiratory infection: interferon-α2 (IFNα2), IFNγ, interleukin-10 (IL-10), IL-1β, IL-8, IFN-γ-inducible protein-10, vascular endothelial growth factor, monocyte chemoattractant protein-1, macrophage inflammatory protein-1α (MIP-1α), and MIP-1β.
|
31600771 |
2020 |
|
Kaposi Sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interferon-α2b is FDA approved drug for the treatment of chronic HCV and HBV, melanoma, AIDS-related KS, carcinomas, hairy cell leukemia and chronic myelogenous leukemia.
|
31612813 |
2020 |
|
Malignant melanoma of choroid
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Patients diagnosed with iris, ciliary body or choroidal melanoma with high-risk tumour cytogenetics (monosomy 3) were offered adjuvant treatment with low-dose DTIC and IFN-α-2b following primary therapy.
|
31371315 |
2020 |
|
Lupus Nephritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abbreviations: ALB: albumin; ARHGDIB: Rho GDP dissociation inhibitor beta; APOL1: apolipoprotein L1; ATG5: autophagy related 5; ATG7: autophagy related 7; ATG16L2: autophagy related 16 like 2; BECN1: beclin 1; CDKN1B: cyclin dependent kinase inhibitor 1B; CLEC16A, C-type lectin domain containing 16A; CYBB: cytochrome b-245 beta chain; DC: dendritic cell; DRAM1: DNA damage regulated autophagy modulator 1; eQTL: expression quantitative trait loci; GWAS: genome-wide association study; IFNA: interferon alpha; IRGM: immunity related GTPase M; LRRK2: leucine rich repeat kinase 2; MAP1LC3B: microtubule associated protein 1 light chain 3 beta; MTMR3: myotubularin related protein 3; LAP" LC3-associated phagocytosis; LN: lupus nephritis; NOD: non-obese diabetic; NPHS2: NPHS2, podocin; PBMC: peripheral blood mononuclear cell; RUBCN: rubicon autophagy regulator; SLE: systemic lupus erythematosus.
|
30755075 |
2019 |
|
Tremor
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Culture medium optimization resulted in enhanced production of huIFNα2b in glycoengineered P. pastoris at both shake flask and bioreactor level.
|
30776176 |
2019 |
|
Acute leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Monocytes reprogrammed with lentiviral vectors co-expressing GM-CSF, IFN-α2 and antigens for personalized immune therapy of acute leukemia pre- or post-stem cell transplantation.
|
31628525 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interferon-alpha 2 but not Interferon-gamma serum levels are associated with intramuscular fat in obese patients with nonalcoholic fatty liver disease.
|
30602382 |
2019 |
|
Intraocular pressure disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
The primary measure outcomes were best-corrected visual acuity and central macular thickness; the secondary goals were to assess the effect of topical IFNα2b on the intraocular pressure and its potential side effects.
|
30839494 |
2019 |
|
Diabetic macular edema
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fifty eyes of 50 patients (one eye/patient) who were receiving treatment for diabetic macular edema were randomly assigned to get topical IFNα2b 1 MU/mL or artificial tear eye drop as an adjunctive therapy.
|
30839494 |
2019 |
|
Cytomegalovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
The NK cells of all three HIV-infected groups responded to HCMVsn and IFN-α2 in a manner similar to the NK cells of either HCMV-seronegative or seropositive controls.
|
30483249 |
2018 |
|
Exophthalmos
|
0.010 |
Biomarker
|
disease |
BEFREE |
Exophthalmos responded to pegylated interferon-alpha-2a.
|
30337283 |
2018 |
|
Papilloma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dacryoendoscopy-guided transcanalicular intralesional interferon alpha 2b for canalicular squamous papillomas.
|
28540494 |
2018 |
|
Peyronie Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
CCH and IFNα-2b injected into stable PD plaques can decrease penile curvature; CCH can also improve penile length.
|
30237020 |
2018 |
|
Transient hypothyroidism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transient Hypothyroidism and Autoimmune Thyroiditis in Children With Chronic Hepatitis C Treated With Pegylated-interferon-α-2b and Ribavirin.
|
28953189 |
2018 |
|
Condyloma anal
|
0.010 |
Biomarker
|
disease |
BEFREE |
A total of 104 patients with anal CA were randomly divided into two groups: Patients in the study group were treated with photodynamic therapy combined with imiquimod, and ii) patients in the control group were treated with recombinant human interferon α-2b cream.
|
30344668 |
2018 |
|
Influenza-like symptoms
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
All patients treated with subconjunctival IFN-α-2b reported flu-like symptoms.
|
28967069 |
2018 |
|
Hashimoto Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transient Hypothyroidism and Autoimmune Thyroiditis in Children With Chronic Hepatitis C Treated With Pegylated-interferon-α-2b and Ribavirin.
|
28953189 |
2018 |
|
Autoimmune thyroiditis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transient Hypothyroidism and Autoimmune Thyroiditis in Children With Chronic Hepatitis C Treated With Pegylated-interferon-α-2b and Ribavirin.
|
28953189 |
2018 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Recombinant IFNA2 imparted chemosensitive choriocarcinoma cells with partial resistance to methotrexate, while chemoresistant choriocarcinoma cells were uniquely sensitive to fludarabine, a STAT1 inhibitor.
|
28295835 |
2017 |
|
Keratoconjunctivitis, Vernal
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study was designed to compare tacrolimus and interferon alpha-2b (IFN alpha-2b) eye drops in the treatment of VKC.
|
28399035 |
2017 |
|
Liver neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Human hepatoma (Huh-7 and Huh-7.5) and primary HFLCs were incubated with TNF and/or recombinant IFNA2A, IFNB, IFNL1, and IFNL2 before or during HCV infection.
|
28456632 |
2017 |
|
Myasthenia Gravis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IFNA-AS1 regulates CD4<sup>+</sup> T cell activation in myasthenia gravis though HLA-DRB1.
|
28822831 |
2017 |
|
neurofibroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We validated type-I interferon expression in neurofibroma by protein profiling, and show that treatment of neurofibroma-bearing mice with polyethylene glycolyated (PEGylated) type-I interferon-α2b reduces the expression of many cytokines overexpressed in neurofibroma.
|
28256556 |
2017 |
|
Sleep disturbances
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Resveratrol in Hepatitis C Patients Treated with Pegylated-Interferon-α-2b and Ribavirin Reduces Sleep Disturbance.
|
28820468 |
2017 |