|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heterozygous losses were found in 8/14 (57%) fresh melanoma biopsy DNAs with the smallest region of overlap (SRO) being between IFNA and D9S169.
|
8108124 |
1994 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data confirm the existence of a melanoma susceptibility gene on 9p and indicate that this locus most probably lies outside of the IFNA-D9S126 interval.
|
8213823 |
1993 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventeen SN tested for loss of heterozygosity (LOH) at 9p and 10q regions, known to be frequently deleted in melanoma, showed LOH at the 9p loci D9S942 and IFNA.
|
17518771 |
2007 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the PanScan data, initial associations were found with melanoma susceptibility variants in NCOA6 [rs4911442; OR, 1.32; 95% confidence interval (CI), 1.03-1.70; P = 0.03], YWHAZP5 (rs17119461; OR, 2.62; 95% CI, 1.08-6.35; P = 0.03), and YWHAZP5 (rs17119490; OR, 2.62; 95% CI, 1.08-6.34; P = 0.03), TYRP1 (P = 0.04), and IFNA13 (P = 0.04).
|
24642353 |
2014 |
|
melanoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that CSF-470 vaccine plus BCG plus GM-CSF can significantly prolong, with lower toxicity, the DMFS of high-risk CM pts with respect to medium-dose IFN-α2b.
|
28620382 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Infection by measles virus (MV) induces type I IFN via the retinoic acid-inducible gene I/melanoma differentiation-associated gene 5/mitochondrial antiviral signaling protein (MAVS) pathway in human cells.
|
24078691 |
2013 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Inactivation of the IFN pathway is mediated by the IFN receptor IFNAR1 downregulation that invariably occurs during melanoma development.
|
27052162 |
2016 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In a previous study on melanoma cell lines we found that greatest sensitivity to IFN was found in cell lines with the greatest number of copies of chromosome 9p, where the IFN gene family is located.
|
10596911 |
1999 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Poly I:C was not able to induce melanocytes or melanoma cells to produce detectable amounts of IFN-alpha protein, but able to induce a significant amount of IFN-beta in melanocytes and two of the melanoma cell lines: MMAc and VMRC-MELG.
|
12096926 |
2002 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that restoration of IFN-stimulated genes by co-administration of the demethylating drug 5-aza-2'-deoxycitidine (decitabine [DAC]) may enhance the susceptibility to IFN-I-mediated antitumoral effects in melanoma.
|
27623509 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IFN-α2b-treated high-risk cutaneous melanoma patients in a Phase II study.
|
29109725 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In these contexts, targeted overexpression of hPNPase(old-35) might be a novel therapeutic strategy for c-myc-overexpressing and IFN-resistant tumors, such as melanomas.
|
16410805 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both physicians and patients rated melanoma recurrence much lower than even severe IFN side effects.
|
29899854 |
2018 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
High-dose interferon alfa-2b (IFN-α-2b) improves the survival of patients with high-risk melanoma.
|
28710916 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To further determine the significance of this observation, 17 melanoma cell lines sensitive or resistant to the antiproliferative effects of IFN-alpha2 and IFN-beta, as well as 30 melanoma patient samples, were analyzed for Stat1 levels by either Western blot analysis or immunohistochemistry.
|
12060499 |
2002 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We plan to use gamma-IFN--transduced autologous tumor cells to boost host immune responses as a potential therapy for human melanoma.
|
8024193 |
1994 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that a defect in the level of STAT1 and possibly all three ISGF3 components in IFN-resistant human melanoma cells may be a general phenomenon responsible for reduced cellular responsiveness of melanomas to IFNs.
|
9353349 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The unique de novo and IFN-modified antigenic phenotype of cultures derived from different patients indicates that the antigenic phenotype displayed by melanoma cultures grown in vitro is genetically determined.
|
2118485 |
1990 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Patients who undergo surgical excision of stage III MM appear to enjoy prolonged DFS and OS when treated with TIL + IFN-<i>α</i> compared to IFN-<i>α</i> alone.
|
28913367 |
2017 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Subtraction hybridization combined with induction of cancer cell terminal differentiation in human melanoma cells identified melanoma differentiation-associated gene-7/interleukin-24 (mda-7/IL-24) and SARI (suppressor of AP-1, induced by IFN) that display potent antitumor activity.
|
24282278 |
2014 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, the level of Mx-homologous protein induced during IFN therapy is not a predictive marker for an antitumor response in malignant melanoma.
|
1701809 |
1990 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Binding studies indicated the presence of 2,980 +/- 170 receptors per cell, each with an apparent Kd of (8.4 +/- 1.3) X 10(-11) M. Results from competitive binding studies suggested that Hs294T cells possess at least two types of IFN receptors: one which binds IFN-alpha A and IFN-beta 1 and another to which IFN-gamma binds.
|
6319748 |
1984 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Direct intratumoral injection of 100 microg of a IFN-omega pDNA DMRIE/DOPE complex (1:1 DNA:DMRIE mass ratio) for 6 consecutive days resulted in a significant reduction in the tumor volume of NIH: OVCAR-3 ovarian carcinoma or A375 melanoma (P = 0.02).IFN-omega pDNA delivered by i.m. injection also had an antitumor effect.
|
10463608 |
1999 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice incapable of downregulating the IFN receptor and Ch25h were resistant to TEV uptake, TEV-induced pre-metastatic niche, and melanoma lung metastases; however, ablation of Ch25h reversed these phenotypes.
|
30645975 |
2019 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings, if confirmed, might indicate that IFN and glucocorticoid hormones are not mutually exclusive in the management of human melanoma.
|
7543821 |
1995 |