Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, the results suggest that macrophages may be important regulators of IFN-gamma production in bladder cancer patients.
|
6426791 |
1984 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In an attempt to quantify this phenomenon in bladder tumors, frozen sections were stained immunochemically and cell lines were tested in a radiobinding assay before and after treatment with interferon gamma (IFN gamma) and after attempts to correct the defect by normal human leukocyte antigen (HLA) gene transfection.
|
7621243 |
1994 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study explored the use of interleukin 2 (IL-2) and interferon gamma (IFN-gamma) gene-modified tumor cells as cellular vaccines for the treatment of bladder cancer.
|
8459207 |
1993 |
Bladder Neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, the results provide a first glance at the effect of IFN-gamma on the protein expression profiles of TCCs, and in due course may form the basis for more comprehensive studies aimed at evaluating the usefulness of this cytokine in bladder cancer management.
|
10197441 |
1999 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Because bladder is suitable for the intravesical instillation of therapeutic agents, in vivo administration of retroviral vectors encoding IFN-gamma may be explored for the treatment of bladder cancer.
|
11219496 |
2001 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interferon-gamma up-regulates toll-like receptor 4 and cooperates with lipopolysaccharide to produce macrophage-derived chemokine and interferon-gamma inducible protein-10 in human bladder cancer cell line RT4.
|
16094077 |
2005 |
Bladder Neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Here we present data from the same clinical trial in bladder cancer patients demonstrating a higher frequency of CD4(+)ICOS(hi) T cells and IFN-gamma mRNA levels in nonmalignant prostate tissues and incidental prostate tumor tissues removed at the time of radical cystoprostatectomy.
|
19202079 |
2009 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association of interleukin-1beta (IL-1B) -511C > T and IL-1 receptor antagonist (IL-1RN) VNTR, transforming growth factor-beta (TGF-B1) +28C > T and interferon-gamma (IFN-G) + 874T>A polymorphisms with bladder cancer (CaB) susceptibility and risk of recurrence in Bacillus Calmette-Guérin (BCG)-treated patients was analyzed in 287 controls and 213 CaB patients (73 BCG treated).
|
19489682 |
2009 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
More importantly, despite the commonly appreciated process of IFN-γ induced apoptosis, IFN-γ at low concentrations stimulated bladder cancer cell proliferation, consistent with apoptosis being dependent on an overstimulation of what is otherwise a pro-proliferative pathway.
|
25236570 |
2014 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
APOBEC mutagenesis is associated with increased expression of immune signatures, including interferon signaling, and expression of <i>APOBEC3B</i> is increased after stimulation of APOBEC-high bladder cancer cell lines with IFNγ.
|
29435122 |
2018 |
Bladder Neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The elevated glutaminolysis of bladder cancer and T cells in a simulated tumor microenvironment contributes to the up-regulation of PD-L1 expression by interferon-γ.
|
30425515 |
2018 |