|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
IFN-gamma gene polymorphism might be important in determining individual's susceptibility to intrauterine HBV infection.
|
16718821 |
2006 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the effect of recombinant human interferon-gamma on duck hepatitis B virus replication in human hepatoma cells (Huh 7) transiently transfected with cloned duck hepatitis B virus DNA.
|
7685809 |
1993 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of interleukin-18-mediated cell signaling and interferon gamma expression by the hepatitis B virus e antigen.
|
24872585 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interferon-gamma sensitizes hepatitis B virus-expressing hepatocarcinoma cells to 5-fluorouracil through inhibition of hepatitis B virus-mediated nuclear factor-kappaB activation.
|
17711513 |
2007 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Detection of Helicobacter pylori DNA in the liver was independently associated with hepatitis B virus/hepatitis C virus, pancreatic carcinoma and a cytokine pattern characterised by high interleukin (IL)-10, low/absent interferon-γ and decreased IL-17A concentrations (p < 10(-3)).
|
22012231 |
2011 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Unresponsiveness to Hepatitis B virus (HBV) vaccine has been associated with interleukins involved with Th1 functioning including Interleukin-8 (IL-18) and Interferon-γ (IFN-γ).
|
28673589 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Healthy individuals who recovered from HBV infection had a similar distribution of IFN-gamma gene polymorphism as the healthy controls.
|
12526950 |
2003 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
The frequency of HBV-specific T cells producing IFN-γ after stimulation with HBV epitopes was similar in CHB and RHB patients.
|
26526193 |
2015 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Overall, the current study reveals that NK cells, especially DX5(+)CD49a(-) conventional NK cells, promote the antiviral activity of CD8(+) T cell responses via secreting IFN-γ in a mouse model mimicking acute HBV infection.
|
27183639 |
2016 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
CXCR5<sup>+</sup>CD8<sup>+</sup>T cells are partially exhausted while possess a more potent antiviral activity through producing high levels of HBV-specific IFN-γ and IL-21 in chronic HBV infection.
|
31610223 |
2020 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
The antiviral cascade triggered by interferon-gamma (IFN-gamma) represents a vital event for eradicating hepatitis B virus (HBV) in experimental animals.
|
19488747 |
2009 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD56<sup>bright</sup> NK cells of chronic HBV patients differed in their ability to produce IFN-γ between the clinical phases pre- and post-HBeAg seroconversion.
|
28093337 |
2017 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Less proliferation and lower levels of IL-2 and IFN- γ were also observed in the patient group compared with the control group (P < 0.05).These data suggest that HBV DNA infected and integrated into the BM HSCs from patients with chronic HBV infection and that these BM HSCs generated defective T cells.
|
24620791 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, tumor necrosis factor (TNF) and interferon-gamma (IFN-γ) have critical functions in non-cytopathic elimination of hepatitis B virus (HBV) in hepatocytes.
|
30115930 |
2018 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
There was no difference in the HBV DNA levels during hepatitis flares between patients with genotypes B and C. Patients with genotype B had a significantly higher number of IFN-gamma producing cells [with hepatitis B core antigen (HBcAg) stimulation] and lower number of IL-10 producing cells (with HBcAg and HBeAg stimulation) compared with patients with genotype C (P = 0.011, =0.043, <0.001 respectively).
|
17381719 |
2007 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
On the basis of unconditional logistic regression analysis with adjustment for age and sex, no statistically significant association with susceptibility to persistent HBV infection was observed with the IFN-gamma, IFNGR-1 and 2, and IRF-1 gene polymorphisms under the codominant, dominant, and recessive models.
|
16944293 |
2006 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The study indicated that low IFN-γ expression probably impairs host immune response to HBV, rendering these subjects more prone to HBV infection.
|
24446686 |
2014 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Natural killer cells are characterized by the concomitantly increased interferon-γ and cytotoxicity in acute resolved hepatitis B patients.
|
23133672 |
2012 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results indicated a statistically significant association between the IFN-γ +874T/A polymorphism and hepatitis virus-related diseases in a recessive gene model (AA vs. TT+TA: OR=1.350, 95% CI=1.101-1.657, P=0.004, I2%=54.3, and PQ=0.001 for heterogeneity), especially in Asians (OR=1.407, 95% CI=1.035-1.911, P=0.029, I2%=61.9, and PQ=0.005 for heterogeneity) and hepatitis B virus (HBV)-related disease (OR=1.486, 95% CI=1.195-1.849, P=0.000, I2%=40.4, and PQ=0.053 for heterogeneity).
|
25939029 |
2015 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
However, the role and regulation in HBV infection of IFN-gamma have not been defined.
|
12858406 |
2003 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In summary, high-IFNG-producing alleles in intron 1 of the IFNG locus are associated with high [tsIgE] in asthmatic children from Niue and with natural immunity to the HBV in Polynesian women.
|
17211638 |
2007 |
|
Hepatitis B
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-32, IL-1, and IFN-γ protein levels in serum from hepatitis B patients were significantly higher than those in healthy volunteers (P<0.05).
|
30006119 |
2019 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to evaluate whether IFN-gamma gene polymorphisms or its haplotypes might be associated with predisposition to hepatitis B virus (HBV) infection in the Chinese population.
|
17033822 |
2006 |
|
Hepatitis B
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we investigated the role of the early activation marker, CD69 and effector cytokines, granzyme B (GrB) and IFN-γ in the exhaustion of innate-like TCR Vα7.2<sup>+</sup>CD4<sup>+</sup>T cells, in 15 individuals with chronic HBV (CHB) infection where six were HBV DNA<sup>+</sup> and nine were HBV DNA<sup>-</sup>.
|
28606013 |
2017 |
|
Hepatitis B
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that the polymorphism at position -183 of the IFN-gamma gene promoter may be associated with susceptibility to HBV infection, and age and gender factors are coordinative risk factors.
|
16302211 |
2005 |