Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The findings in our study suggest that STAT1 rs1467199 SNP plays a potential role in the IFN-γ dependent development of autoimmunity in children with ITP.
|
25707685 |
2015 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Tumor necrosis factor and interferon gamma: relevance for immune regulation and genetic predisposition to autoimmune disease.
|
1627786 |
1992 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Blocking the transcription of the IFN-gamma gene with kinase inhibitors might lead to the development of novel therapeutic agents for patients with aplastic anemia and other autoimmune diseases.
|
16434488 |
2006 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Interferon-gamma (IFN-γ) is a paracrine inhibitor of melanocytes and genetic variability due to intron 1 polymorphisms in IFNG has been reported to be associated with increased risk for several autoimmune diseases.
|
23777204 |
2013 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Overall, we show that MHC presentation and the adaptor functions of 14-3-3ζ participate in promoting IFN-γ and IL-17 production, two of the cytokines commonly associated with autoimmune diseases.
|
31396202 |
2019 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In addition, the anti-apoptotic gene BCL3, interferon-γ (IFNG), and the vitamin D receptor (VDR) gene physically interact with significantly many genes that tend to be differentially expressed in PBMCs of patients with the analyzed autoimmune diseases.
|
23190644 |
2013 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We conclude that a shift in immunodominance of self-antigenic determinants of Col-V results in induction of IFN-γ and IL-17 with loss of tolerance leading to autoimmunity to Col-V, which leads to chronic lung allograft rejection.
|
22132895 |
2012 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We have studied the CA repeat polymorphisms in the first intron of IFN gamma gene in Japanese patients with GD (n = 162) and healthy control subjects without antithyroid autoantibodies or family history of autoimmune disorders (n = 133).
|
15068623 |
2004 |
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
This meta-analysis indicates that the IFN-γ +874 T/A polymorphism may play a significant role in modifying the risk of autoimmune diseases in Caucasian, Latin American, and Middle Eastern subjects, and in particular shows that the IFN-γ +874 T/A polymorphism is associated with increased genetic susceptibility to idiopathic thrombocytopenic purpura and SLE.
|
26703437 |
2016 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
C-terminal truncation of IFN-γ inhibits proinflammatory macrophage responses and is deficient in autoimmune disease.
|
29925830 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
A marked reduction of IL-2 was also observed for all CT relatives with autoimmunity and a lack of IFN-γ production was observed for the younger brother of the index patient, heterozygous for the polymorphism.
|
22809281 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Pathogenic functions of B cells in autoimmune diseases: IFN-γ production joins the criminal gang.
|
25727209 |
2015 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Development of autoimmunity in smokers with emphysema is also strongly linked to the expansion of autoreactive T helper (Th) cells expressing interferon gamma (Th1), and interleukin 17A (Th17).
|
31112138 |
2019 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These ex-Th17 cells are also called nonclassical Th1 cells because of their ability to produce IFN-γ, similar to Th1 cells; however, it is unclear whether they resemble Th1 or Th17 cells in terms of their function and regulation, and whether they have a pathogenic role in autoimmunity.
|
28167631 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These data implicate interleukin-12-dependent IFNγ-mediated immunity as a determinant of invasive NTS disease in African children, and highlight the shared genetic architecture of infectious and autoimmune disease.
|
29523850 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
IFN-γ-Expressing Th17 Cells Are Required for Development of Severe Ocular Surface Autoimmunity.
|
28637904 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In addition, IL-17/IFNγ double-producing cells have been identified in disorders in which the role of autoimmunity remains unclear, such as sarcoidosis.
|
29275836 |
2018 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Gold- and silver-induced murine autoimmunity--requirement for cytokines and CD28 in murine heavy metal-induced autoimmunity.
|
19077085 |
2009 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate the consequences of a chronic IFN-γ milieu on B220(+) cell types and in particular the impact of MZB cell loss on MZM function in autoimmunity.
|
24583068 |
2014 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Two of these clusters are highly enriched in pathways previously associated with autoimmune disease etiology (TNFα and IFNγ cytokine pathways).
|
28982122 |
2017 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Signal transducer and activator of transcription 4 (STAT4) transmits signals induced by interleukin-12, interleukin-23 and interferon-γ, which are key cytokines and play important roles in the development of autoimmune diseases.
|
23727609 |
2013 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Besides being crucial for mycobacterial control, the interferon-gamma/interleukin-12 pathway is also involved in the pathogenesis of autoimmune disease, as well as tumor development and control.
|
14758107 |
2004 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
In this review we focus on the new developments in the areas of IFN gamma biochemistry and biology and pay particular attention to the IFN gamma receptor and three aspects of IFN gamma biology that are of special interest to immunologists: host defense, inflammation, and autoimmunity.
|
8476573 |
1993 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Interferon-gamma is a potent Th1-type cytokine and a key molecule in the pathogenesis of autoimmune diseases including lupus nephritis.
|
20167631 |
2010 |
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, GSTT1-AS1 (r = 0.313, p = 0.027) and (IFNG r = 0.478, p < 0.0001) demonstrated a significant positive correlation with age at onset.Briefly, the current study provided for the first time dysregulation of GSTT1-AS1 and IFNG-AS lncRNAs network in MS, which highlights the significant role of epigenetic pathways in this autoimmune disorder.
|
30680474 |
2019 |