|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-IR may be a potential therapeutic target for human colon cancer.
|
19608011 |
2009 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
β-catenin/TCF activity regulates IGF-1R tyrosine kinase inhibitor sensitivity in colon cancer.
|
29895971 |
2018 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
KW-2450 40 mg/kg showed modest growth inhibitory activity and inhibited IGF-1-induced signal transduction in the murine HT-29/GFP colon carcinoma xenograft model.
|
26850678 |
2016 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A high sucrose-to-fiber ratio increased risk of colon cancer in men who had the IRS2 DD genotype and among men who did not have the 192/192 IGF1 genotype.
|
15688407 |
2005 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Colon cancer overexpresses insulin-like growth factor 1 (IGF1) and insulin-like growth factor 1 receptor (IGF1-R), as compared with normal or adenomatous mucosa, and it has been postulated that colorectal cancer cells depend on the IGF1/IGF1-R pathway for their growth and progression.
|
14633695 |
2003 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that the colon cancer cell lines Caco2, HT29, SW837, and SW480 express high levels of the IGF-1R receptor, and that both SW837 and SW480 cells display constitutive activation of this receptor.
|
16053920 |
2005 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R/Wnt and activation of p53 signaling pathways.
|
20504360 |
2010 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MGF appears to be overexpressed in colon cancer tissues, offering a potential unique target for imaging and drug delivery in colon cancer.
|
30952709 |
2019 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In support, using public databases showed that increased IGF1 expression was significantly associated with a poorer prognosis in patients with colon cancer.
|
30257507 |
2018 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Based on these findings, the effect of the IGF-1R-inhibitory cyclolignan picropodophyllin (PPP) was assessed in the four colon carcinoma cell lines HT-29, HCT-116, DLD-1 and CaCO-2.
|
22159423 |
2012 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The mitogenic effects of IGF-I on 4 colon carcinoma cell lines were transient because the inactivating phosphorylation of forkhead1 by akt was short-lived.
|
11920634 |
2002 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have found no IGF-I mRNA in breast (zero of 11) or colon cancer (zero of 9) cell lines; both of these tumors have been previously reported to express IGF-I mRNA.
|
2747657 |
1989 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-IR is a valid target for the therapy of human colon cancer.
|
12379772 |
2002 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
HT29 human colon cancer cells were treated with IGF-I for various time periods.
|
9731515 |
1998 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These data provide the first evidence that specific siRNA fragment (pkD-shRNA-IGF-1R-V2) targeting human IGF-1R mRNA is able to enhance colon cancer radiosensitivity.
|
20001499 |
2010 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor-binding protein-2 inhibits proliferation of human embryonic kidney fibroblasts and of IGF-responsive colon carcinoma cell lines.
|
9742949 |
1998 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also show a correlation between IGF-1 pathway activation and the infiltration of myeloid cells with active p38α in colon samples from patients with ulcerative colitis or colon cancer.
|
29907597 |
2018 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Antiproliferation effect of evodiamine in human colon cancer cells is associated with IGF-1/HIF-1α downregulation.
|
26503233 |
2015 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have examined a number of human adult tumors for IGF messenger RNA (mRNA) expression and found IGF-II mRNA levels were consistently elevated in two types, colon carcinoma and liposarcoma.
|
3779638 |
1986 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that overexpression of alpha1-PDX and knockdown of furin expression inhibited processing of IGF-1 receptor and its subsequent activation by IGF-1 to induce IRS-1 and Akt phosphorylation, all important in colon carcinoma metastasis.
|
18064302 |
2008 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Increased expression of the type I insulin-like growth factor receptor (IGF-1R) is associated with colon cancer, while the antioxidant N-acetyl-l-cysteine (NAC) is known to suppress colonic proliferation.
|
12485928 |
2002 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
However, the role of IGF-1 on the growth of colon cancer cell line HCT-8 is not clear.
|
21638027 |
2011 |
|
Colon Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This study has demonstrated that overexpression of IGF-I and IGF-IR contributes to the development and progression of colon cancer.
|
27737962 |
2016 |
|
Colon Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with an IRS1 R allele and IGF1 non-192 allele were at a 2-fold increased risk of colon cancer (95% CI 1.2-4.4).
|
15247132 |
2004 |
|
Colon Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
As has already occurred for malignancies such as breast or colon cancer, the "-omics-based" revolution has enhanced our understanding of the molecular changes responsible for Ewing's tumor formation and identified a number of potential targets (such as IGF-1R or mTOR) amenable to biological therapy.
|
19533369 |
2009 |