Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the present study, we analyzed IGF and IGF receptor mRNA transcripts from two related human neuroblastoma cell lines, SH-SY5Y and SK-N-SH.
|
1331680 |
1992 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, inasmuch as all neuroblastoma (12 of 12) cell lines examined expressed IGF-II RNA, the pattern of IGF expression could distinguish between these closely related tumors.
|
2174908 |
1990 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Insulin-like growth factor I regulates c-myc and GAP-43 messenger ribonucleic acid expression in SH-SY5Y human neuroblastoma cells.
|
8477653 |
1993 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
To better understand the roles of IGF-IR and its ligand, IGF-II, in NBL carcinogenesis, we stably transfected SHEP cells with either IGF-II or IGF-IR.
|
8813151 |
1996 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factor-I is an osmoprotectant in human neuroblastoma cells.
|
9200735 |
1997 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have studied the expression of IGF, IGFBP and IGF receptor mRNA in two human neuroblastoma cell lines, SK-N-MC and CHP, and asked whether or not the expression of the IGF system in these malignant cells determines their growth pattern.
|
9404729 |
1997 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Insulin-like growth factors I and II (IGF-I and IGF-II) are actively involved in neuroblastoma cell growth.
|
9563481 |
1998 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Retinoic acid stimulates IGF binding protein (IGFBP)-6 and depresses IGFBP-2 and IGFBP-4 in SK-N-SH human neuroblastoma cells.
|
9795362 |
1998 |
Neuroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
In the current study, we report that IGF-I induces a sustained tyrosine phosphorylation of Shc and its association with Grb2 in SH-SY5Y human neuroblastoma cells.
|
9852124 |
1998 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide the first evidence of a direct link between them and demonstrate the effects of the oncogene on components of the IGF system in neuroblastoma cell growth in vitro and in vivo.
|
10383152 |
1999 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study we show that insulin-like growth factor 1 (IGF-1) and tetradecanoyl phorbol acetate (TPA) induce RARbeta gene expression in neuroblastoma SH-SY5Y cells.
|
10498893 |
1999 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The current study examines the effect of IGF-IR expression and activation on apoptosis in SHEP human neuroblastoma cells.
|
10889510 |
2000 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bcl-2 and M-Myc coexpression increases IGF-IR and features of malignant growth in neuroblastoma cell lines.
|
11571630 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study the expression of uncoupling protein 3 (UCP3) and its regulation by insulin-like growth factor 1 (IGF-I) and insulin in human neuroblastoma SH-SY5Y cells were characterized.
|
11587536 |
2001 |
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We showed previously that PS1 exon 9 deletion (PS1 DeltaE9) and L250S mutations predispose SH-SY5Y neuroblastoma cells to high glucose stress-induced apoptosis and that the anti-apoptotic effect of insulin-like growth factor I (IGF-I) is compromised by these mutations.
|
11746362 |
2001 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IGF system in neuroblastoma xenografts: focus on IGF-binding protein-6.
|
11874695 |
2002 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Four neuroblastoma cell lines were examined for their expression of IGF-II and IGF-receptor.
|
12553057 |
2003 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, we analyze the effect of beta1 integrin and IGF-IR on NBL cell attachment and migration.
|
15256055 |
2005 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression of the repressor element-1 silencing transcription factor (REST) is influenced by insulin-like growth factor-I in differentiating human neuroblastoma cells.
|
15654842 |
2005 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that regulation by cofilin of actin depolymerization is important in the process of neuroblastoma cell motility, and IGF-I regulates cofilin activity in part through PI-3K, rac, and LIM kinase.
|
15719172 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Topotecan blocks hypoxia-inducible factor-1alpha and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells.
|
15930297 |
2005 |
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
IGF-I (100 ng/ml) increased incorporation of 3H-thymidine in neuroblastoma SK-N-SHEP cells by approximately 30%, an effect blunted by exogenously added native or either mutant IGFBP-2.
|
15994346 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated whether the survival activity of insulin-like growth factor-I (IGF-I) in SH-SY5Y human neuroblastoma (NBL) cells is associated with phosphorylation and/or localization changes in forkhead proteins.
|
16133873 |
2005 |
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recently, we have shown that insulin-like growth factor-I and serum-derived growth factors stimulate VEGF expression in neuroblastoma cells via induction of hypoxia-inducible factor-1alpha (HIF-1alpha).
|
16618748 |
2006 |
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The human neuroblastoma SH-SY5Y cells stably transfected with these two Chinese presenilin 1 mutations were established to explore whether they are sensitive to, or influenced by, serum deprivation and protected by insulin-like growth factor-1 (IGF-1).
|
18706205 |
2008 |