APOE, apolipoprotein E, 348

N. diseases: 1049; N. variants: 62
Disease: Coronary Artery Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and coronary heart disease. 1288976 1992
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE To determine the influence of the apolipoprotein E polymorphism on the occurrence of coronary artery disease (CAD) and on serum lipids, lipoproteins and apolipoproteins we studied 145 patients with angiographically defined CAD and compared them with 153 control subjects without history or complaints of vascular disease and with 35 subjects without significant stenosis on coronary arteriography. 1947727 1991
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphism is a genetic determinant of plasma lipid levels and of coronary heart disease risk. 2036207 1991
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 Biomarker disease BEFREE The relationship between apolipoprotein E (Apo E) phenotypes and progression of coronary atherosclerosis was investigated in 125 patients with coronary artery disease (CAD) proven angiographically (101 males, 24 females). 2353352 1990
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apoprotein E polymorphism and coronary artery disease. Increased prevalence of apolipoprotein E-4 in angiographically verified coronary patients. 2923580 1989
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 AlteredExpression disease BEFREE A mutant form of apolipoprotein E that is defective in binding to low density lipoprotein receptors is associated with familial type III hyperlipoproteinemia, a genetic disorder characterized by elevated plasma cholesterol levels and accelerated coronary artery disease. 3283935 1988
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Evidently, apolipoprotein E polymorphism can contribute to total and LDL-cholesterol concentrations in serum, thereby affecting risk of coronary heart disease and myocardial infarction. 3698268 1986
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E polymorphism and coronary artery disease. 6882285 1983
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E polymorphism, serum lipids, myocardial infarction and severity of angiographically verified coronary artery disease in men and women. 7605379 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 Biomarker disease BEFREE Apolipoprotein E (apoE) is a genetic determinant of coronary heart disease and lipid levels in several populations. 7616113 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Polymorphisms of the apolipoprotein E gene and severity of coronary artery disease defined by angiography. 7627692 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E (apoE) epsilon 4 allele has been associated with a high risk for coronary heart disease. 7740560 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E polymorphism predicts death from coronary heart disease in a longitudinal study of elderly Finnish men. 7805227 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE To determine whether apolipoprotein E (apo E) polymorphism and the size of low density lipoprotein (LDL) influence postprandial lipemia we studied 39 healthy men and 35 men with CAD. 8060376 1994
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE This aspect of the methodology is illustrated using two population data sets, the first relating APO-E genotype to the frequency of individuals undergoing maintenance hemodialysis and the second relating APO-B genotype to the frequency of coronary artery disease. 8099256 1993
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E (apoE) polymorphism is a genetic determinant of serum lipoprotein levels and coronary heart disease risk. 8354314 1993
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E polymorphism may influence the early development of coronary artery disease. 8488520 1993
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE To determine whether the APOE association may be a risk factor for coronary disease as well, we examined two APOB gene restriction sites that have previously been found to be associated with coronary artery disease, especially myocardial infarctions. 8530010 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Genetic effect of apolipoprotein(a) and apolipoprotein E polymorphisms on plasma quantitative risk factors for coronary heart disease in American black women. 8546757 1995
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE However, context-dependent influences of apolipoprotein E polymorphism on the risk for coronary heart disease have been reported; that is, depending on ethnic origin, gender and lifestyle, apolipoprotein E4 confers a major risk factor for coronary heart disease. 8743896 1996
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 Biomarker disease BEFREE Associations of apoE (E2, E3, or E4) with risk factors and IMT were evaluated in general linear models adjusted for age, sex, and CAD status with and without other traditional risk factors. 8841324 1996
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Apolipoprotein E alleles and risk of coronary disease. A meta-analysis. 8857921 1996
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE Genetic polymorphism at the apolipoprotein E locus (APOE) has been shown to have a significant impact on quantitative risk factors for coronary artery disease (CAD) in diverse populations. 8879432 1996
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 Biomarker disease BEFREE The combined risk of coronary heart disease and APOE*4 was 6.1 (1.7 to 22.3). 8969786 1996
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.200 GeneticVariation disease BEFREE The role of the apolipoprotein E polymorphism in the prediction of coronary artery disease age of onset. 9084929 1997