|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We observed SNPs within the HLA, MAPT and APOE regions jointly contributing to increased risk for FTD and AD or PD.
|
27899424 |
2017 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
The combined alleles frequency of CYP2D6*3 + apoE4 was significantly higher not only in the PD group (33.3%) but also in patients with parkinsonism (22.3%) compared to control subjects (1.6%).
|
10353349 |
1999 |
|
Parkinson Disease
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, results of this exploratory investigation suggest that an APP SNP and an APH1B SNP are marginally associated with PD CSF Aβ42 levels in APOE ɛ4 noncarriers.
|
25808939 |
2015 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We studied the association between these two polymorphisms of the APOE gene with PD in a sample of 126 PD patients and in 119 controls from the same geographic background.
|
10624815 |
1999 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Apolipoprotein E (ApoE) genotyping was conducted in sporadic Alzheimer's disease (AD, n = 91) as well as in other dementing disorders including Parkinson's disease (PD, n = 73), autopsy-confirmed diffuse Lewy body disease (DLBD, n = 16), progressive supranuclear palsy (n = 13), vascular dementia (n = 55), alcoholic dementia (n =25) and normal control subjects (n = 77).
|
9187933 |
1997 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To determine the relationship between apolipoprotein E (APOE) polymorphisms to the time to appearance of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.
|
21108621 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The Apolipoprotein E e4e4 genotype was more common in patients with Parkinson disease (7.4%) than in healthy controls (1.4%; P = .03).
|
19321880 |
2009 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The lack of association between the APOE 4 allele and PDD suggests that the pathological process involved in the development of dementia in PD is different from the one that occurs in AD.
|
18930114 |
2008 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Apolipoprotein E genotypes in Parkinson's disease with and without dementia.
|
7847865 |
1995 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The logistic regression analysis showed that high levels of serum cholesterol [odds ratio (OR) = 1.101, 95 % confidence interval (CI95%) = 1.067-1.135], LRPAP1 I allelic variant alone (OR = 2.766, CI95% = 1.137-6.752) and in combination with APOE ε4 allelic variant (OR = 4.187, CI95% = 1.621-10.82) were significantly associated with increase in PD risk.
|
24504617 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.
|
30957308 |
2019 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Whole exome sequencing analysis of known disease-associated genes, copy number analysis, APOE ε genotyping and C9orf72 repeat expansion analysis were performed to identify defects in genes with a well-established involvement in Parkinson's disease or AD.
|
30777654 |
2019 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The main goal of this work was to describe two MJD patients displaying the parkinsonian triad (tremor, bradykinesia and rigidity), namely on what concerns genetic variation in Parkinson's disease (PD) associated loci (PARK2, LRRK2, PINK1, DJ-1, SNCA, MAPT, APOE, and mtDNA tRNA(Gln) T4336C).
|
22023810 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
This study aimed to evaluate the association of APOE polymorphism with PD and its influence on lipid profile.
|
24175296 |
2013 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mean age at onset of PD was not associated to any APOE allele or genotype, but was significantly earlier in familial PD when compared to sporadic cases (P = 0.025).
|
17230455 |
2007 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We determined ApoE genotype in 100 dementia patients with neuropathologically confirmed AD with and without concomitant Parkinson's disease (PD) changes (nigral degeneration and Lewy bodies at various sites).
|
7501146 |
1995 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the role of APOE alleles in PD risk by studying a large sample size and controlling for population substructure.
|
22349451 |
2012 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Among PD patients without dementia, the APOE ε4 allele was only associated with lower performance on word list learning and semantic verbal fluency, a pattern more typical of the cognitive deficits seen in early Alzheimer disease than PD.
|
25178429 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, the impact of APOE genotypes on Parkinson's Disease Dementia (PDD) is still inconclusive.
|
29776682 |
2018 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We apply our method to two genome-wide association data sets and localize both the functional variant REP1 in the α-synuclein gene that conveys susceptibility to Parkinson's disease and the APOE gene responsible for the association signal in the Alzheimer's disease data set.
|
23736218 |
2014 |
|
Parkinson Disease
|
0.200 |
Biomarker
|
disease |
BEFREE |
Despite its importance in lipid transport and atherosclerosis pathogenesis, apoE is associated with neurodegenerative disorders such as Alzheimer's disease (AD) and Parkinson disease, and autoimmune disorders such as multiple sclerosis and psoriasis.
|
21772670 |
2011 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
The apolipoprotein E epsilon 4 allele increases the risk of drug-induced hallucinations in Parkinson's disease.
|
10442253 |
1999 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Task-specific regional activations in Parkinson's disease were linked with genetic variation: the rs4680 polymorphism modulated the effect of levodopa therapy on planning-related activations in the frontoparietal network; the MAPT haplotype modulated parietal activations associated with spatial rotations; and APOE allelic variation influenced the magnitude of activation associated with memory encoding.
|
25080285 |
2014 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the ApoE epsilon 4 allele does not function as a risk factor which influences the development of AD lesions in PD.
|
8702415 |
1996 |
|
Parkinson Disease
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
In Asian subgroups, the APOE ε4 allele was shown to be a risk factor for PD (OR = 1.22, 95% CI: 1.01-1.46; P = .04).
|
30526202 |
2019 |