Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We recently reported that a majority of human colon cancers express and secrete the potent mitogen IGF-II and at least two inhibitory binding proteins, IGFBP-2 and IGFBP-4.
|
8612513 |
1996 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we show that the IGF-II peptide content is increased in six primary colon cancers compared to the corresponding healthy tissues.
|
10226796 |
1999 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
CTD_human |
Loss of imprinting of insulin growth factor II gene: a potential heritable biomarker for colon neoplasia predisposition.
|
15057734 |
2004 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This is the same region shown previously to be hypomethylated in colon cancers with IGF2 LOI, but this was not associated with LOI in ovarian cancers.
|
16603642 |
2006 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
A pilot study indicated a significant relationship between LOI of IGF2 and family history as well as personal history of colorectal cancer, suggesting that LOI of IGF2 might be a valuable biomolecular marker of predicting an individual's risk for colon cancer.
|
17325430 |
2007 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
IGF-II LOI is present in high frequency in Chinese colon cancer patients, especially those with proximal cancer.
|
17382534 |
2007 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that IGF2 DMR0 hypomethylation has diagnostic potential for colon cancer rather than value as a surrogate biomarker for constitutive LOI.
|
18541649 |
2008 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The results from this study population do not support the hypothesis that colon cancer can be predicted from the different degrees of methylation of DMR in the IGFII gene from lymphocyte DNA.
|
19549920 |
2009 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Constitutive loss of imprinting (LOI) of IGF2 has been associated with increased risks of colon cancer and adenoma, indicating its role in carcinogenesis.
|
20682317 |
2010 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the associations between IGF2R non-synonymous genetic variants (c.5002G>A, Gly1619Arg(rs629849), and c.901C>G, Leu252Val(rs8191754)), circulating IGF2 levels, and colon cancer (CC) risk among African American and White participants enrolled in the North Carolina Colon Cancer Study (NCCCS).
|
22377707 |
2012 |
Malignant tumor of colon
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the association of four insulin-related pathway gene polymorphisms in insulin-like growth factor-1 (IGF-I) (CA)( n ) repeat, insulin-like growth factor-2 (IGF-II) (rs680), insulin-like growth factor-binding protein-3 (IGFBP-3) (rs2854744), and adiponectin (APM1 rs1501299) with colon cancer risk, as well as relationships with circulating IGF-I, IGF-II, IGFBP-3, and C-peptide in a population-based study.
|
22565227 |
2012 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, IGF2 has been proposed to play a role in the development of a variety of seemingly unrelated cancers that play an important role in geriatric medicine, e.g., breast cancer, colon cancer and lung cancer.
|
23257688 |
2013 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Humoral autoimmune response to IGF2 mRNA-binding protein (IMP2/p62) and its tissue-specific expression in colon cancer.
|
23421499 |
2013 |
Malignant tumor of colon
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of SUZ12 restored normal monoallelic expression of IGF2 in these two colon cancer cell lines.
|
26407907 |
2015 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line.
|
26445041 |
2015 |
Malignant tumor of colon
|
0.400 |
Biomarker
|
disease |
BEFREE |
Taken together, we demonstrate that stroma-induced IGF2 promotes colon cancer progression in a paracrine and autocrine manner and propose IGF2 as potential target for tumor stroma cotargeting strategies.
|
28534511 |
2017 |