Liver carcinoma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
Liver carcinoma
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Liver carcinoma
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Micronodular cirrhosis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
Somatic mutation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Subacute progressive viral hepatitis
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied the regulation by estradiol of the mannose-6-phosphate (Man-6-P)/insulin-like growth factor-II (IGF-II) receptor concentration in different breast cancer cell lines.
|
1656243 |
1991 |
Breast Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have studied the regulation by estradiol of the mannose-6-phosphate (Man-6-P)/insulin-like growth factor-II (IGF-II) receptor concentration in different breast cancer cell lines.
|
1656243 |
1991 |
Fetal Growth Retardation
|
0.240 |
Biomarker
|
phenotype |
RGD |
Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation.
|
1408464 |
1992 |
Type II Mucolipidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mannose 6-phosphate/insulin-like growth factor II receptor in I-cell disease fibroblasts: increased synthesis and defective regulation of cell surface expression.
|
1314098 |
1992 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to determine whether the Man-6-P/IGF-II receptor gene copy number is altered in breast cancer we analysed specimens of invasive breast carcinoma from 51 patients by Southern blotting.
|
8286193 |
1994 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In order to determine whether the Man-6-P/IGF-II receptor gene copy number is altered in breast cancer we analysed specimens of invasive breast carcinoma from 51 patients by Southern blotting.
|
8286193 |
1994 |
Invasive carcinoma of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In order to determine whether the Man-6-P/IGF-II receptor gene copy number is altered in breast cancer we analysed specimens of invasive breast carcinoma from 51 patients by Southern blotting.
|
8286193 |
1994 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity.
|
7493029 |
1995 |
Liver carcinoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Transforming growth factor-beta receptors and mannose 6-phosphate/insulin-like growth factor-II receptor expression in human hepatocellular carcinoma.
|
7639583 |
1995 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Frequent loss of heterozygosity on 6q at the mannose 6-phosphate/insulin-like growth factor II receptor locus in human hepatocellular tumors.
|
7753549 |
1995 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These mutations give rise to truncated receptor protein and significant amino acid substitutions, and provide evidence that the M6P/IGF2R gene functions as a tumour suppressor in human liver carcinogenesis.
|
7493029 |
1995 |
Hepatocarcinogenesis
|
0.050 |
Biomarker
|
disease |
BEFREE |
These mutations give rise to truncated receptor protein and significant amino acid substitutions, and provide evidence that the M6P/IGF2R gene functions as a tumour suppressor in human liver carcinogenesis.
|
7493029 |
1995 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide evidence that M6P/IGF2r allelic loss is an early event in the etiology of breast cancer, that this gene functions as a tumor suppressor gene in the breast.
|
8649861 |
1996 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings provide evidence that M6P/IGF2r allelic loss is an early event in the etiology of breast cancer, that this gene functions as a tumor suppressor gene in the breast.
|
8649861 |
1996 |
Breast Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings provide evidence that M6P/IGF2r allelic loss is an early event in the etiology of breast cancer, that this gene functions as a tumor suppressor gene in the breast.
|
8649861 |
1996 |
Mammary Neoplasms
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Using the polymerase chain reaction, we utilized two polymorphisms in the 3' untranslated region of M6P/IGF2r to screen breast tumors for LOH.
|
8649861 |
1996 |
Liver carcinoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
M6P/IGF2R allele loss was also found in cirrhotic tissue of clonal origin adjacent to these dysplastic lesions and HCCs, demonstrating that M6P/IGF2R inactivation occurs early in liver carcinogenesis.
|
9294214 |
1997 |
Liver carcinoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
The frequent allelic loss and homozygous deletion of the M6P/ IGF2r gene suggest that the M6P/IGF2r gene functions as a tumor suppressor gene in the development of HCC.
|
9570384 |
1997 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We have sought to confirm that allelic loss of IGF2R is an early event in the aetiology of breast cancer by screening a group of 'early' lesions for LOH at a polymorphic microsatellite marker within the IGF2R gene using polymerase chain reaction (PCR).
|
9413941 |
1997 |