Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270846
Disease: Epileptic drop attack
Epileptic drop attack 		0.400 Biomarker disease HPO
CUI: C0494475
Disease: Tonic - clonic seizures
Tonic - clonic seizures 		0.400 Biomarker disease HPO
CUI: C0494475
Disease: Tonic - clonic seizures
Tonic - clonic seizures 		0.400 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET HCN1 channels: a new therapeutic target for depressive disorders? 23033536 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease PSYGENET Our results suggest that HCN1 protein could be a potential target for treatment of anxiety and depression disorders. 22884333 2012
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease BEFREE The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived. 29596995 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.320 Biomarker disease BEFREE HCN1 channels: a new therapeutic target for depressive disorders? 23033536 2012
CUI: C4552072
Disease: X-linked infantile spasms
X-linked infantile spasms 		0.320 GeneticVariation disease BEFREE Among the four known isoforms, HCN1 is the most expressed in the neocortex and hippocampus and de novo HCN1 point mutations have been recently associated with early infantile epileptic encephalopathy. 29936235 2018
CUI: C4552072
Disease: X-linked infantile spasms
X-linked infantile spasms 		0.320 GeneticVariation disease BEFREE De novo mutations in HCN1 cause early infantile epileptic encephalopathy. 24747641 2014
CUI: C4552072
Disease: X-linked infantile spasms
X-linked infantile spasms 		0.320 Biomarker disease CTD_human De novo mutations in HCN1 cause early infantile epileptic encephalopathy. 24747641 2014
CUI: C0009952
Disease: Febrile Convulsions
Febrile Convulsions 		0.310 AlteredExpression disease BEFREE After experimental febrile seizures (i.e., early in the epileptogenic process), the preserved and augmented inhibition onto principal cells may lead to reduced HCN1 expression. 12890777 2003
CUI: C0009952
Disease: Febrile Convulsions
Febrile Convulsions 		0.310 Biomarker disease RGD Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. 15837575 2005
CUI: C0009952
Disease: Febrile Convulsions
Febrile Convulsions 		0.310 Biomarker disease HPO
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 Biomarker disease PSYGENET Our results suggest that HCN1 protein could be a potential target for treatment of anxiety and depression disorders. 22884333 2012
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.310 Biomarker disease BEFREE The hyperpolarization-activated cyclic nucleotide-gated channel 1(HCN1) could be inhibited by the ketamine, a drug to alleviate depression and anxiety, and regulated the BDNF expression, however, the effects of ketamine in alleviating PTSD symptoms by regulating the HCN1-related BDNF have been poorly perceived. 29596995 2018
CUI: C0022333
Disease: Jacksonian Seizure
Jacksonian Seizure 		0.300 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.300 Biomarker disease HPO
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.300 Biomarker disease RGD Together, these results show that HCN1 channelopathy begins rapidly and persists after SE, involves both transcriptional and nontranscriptional mechanisms, and may be an early contributor to epileptogenesis. 21976514 2011
CUI: C0086237
Disease: Epilepsy, Cryptogenic
Epilepsy, Cryptogenic 		0.300 Biomarker disease CTD_human Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. 12890777 2003
CUI: C0234533
Disease: Generalized seizures
Generalized seizures 		0.300 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
CUI: C0234535
Disease: Clonic Seizures
Clonic Seizures 		0.300 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
CUI: C0750940
Disease: Tremor, Rubral
Tremor, Rubral 		0.300 Biomarker disease CTD_human Gabapentin treatment improves motor coordination in a mice model of progressive ataxia. 19747469 2009
CUI: C0751110
Disease: Single Seizure
Single Seizure 		0.300 Biomarker disease CTD_human Increased seizure severity and seizure-related death in mice lacking HCN1 channels. 20384728 2010
CUI: C0751111
Disease: Awakening Epilepsy
Awakening Epilepsy 		0.300 Biomarker disease CTD_human Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. 12890777 2003
CUI: C3463992
Disease: EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1 		0.300 Biomarker disease CTD_human De novo mutations in HCN1 cause early infantile epileptic encephalopathy. 24747641 2014