|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Tumor tissues (73.9 %) had concurrent methylation of two or more genes, with the most frequent combination as KLOTHO and IGFBP7 (53.8 %).
|
24852431 |
2014 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Further functional analysis showed that the IGFBP7 -418A allele had significantly higher promoter and DNA-protein binding activities than did the G allele, suggesting a tumor suppressor role of this allelic change in the SCCHN etiology.
|
20599521 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our study clearly demonstrated that IGFBP7 plays a potential tumor suppressor role against colorectal carcinogenesis and its expression is associated with DNA hypomethylation of exon 1.
|
17048309 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show here that in contrast to its tumor-suppressor function in epithelial cells, IGFPB7 can promote anchorage-independent growth in malignant mesenchymal cells and in epithelial cells with an EMT phenotype when IGFBP7 is expressed by the tumor cells themselves and can induce colony formation in colon cancer cells co-cultured with IGFBP7-expressing CAFs by a paracrine tumor-stroma interaction.
|
24632618 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The important role of insulin-like growth factor binding protein 7 (IGFBP7) as a tumor suppressor in solid tumors has been revealed in several studies.
|
21040219 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor-binding protein 7 (IGFBP7) is a selective biomarker of glioblastoma (GBM) vessels, strongly expressed in tumor endothelial cells and vascular basement membrane.
|
18711401 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The data suggest that IGFBP-rP1 is a tumour suppressor inactivated by DNA methylation in human lung cancer.
|
17236181 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study was to ascertain the utility of the RAF/RAS mutational status as a diagnostic adjunct in lesions with histologic features that deviate from a typical Spitz nevus and, to examine expression of Insulin growth factor binding protein 7 (IGFBP7), a tumor suppressor acting through autocrine/paracrine pathways to inhibit BRAF-MEK-ERK signaling, in the same.
|
19788444 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently it has been suggested that mac25 plays a tumor-suppressive role in various tumors.
|
10698042 |
2000 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results demonstrate that IGFBP-rP1 strongly suppresses tumor growth by an insulin-independent or insulin-like growth factor-independent mechanism.
|
17465992 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor binding protein 7 (IGFBP7) is reported to have tumour suppressor function through an IGF-dependent pathway in various malignant tumours.
|
26043748 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In a nude mice subcutaneous model, xenografts from human HCC cells were established in both flanks and only left-sided tumors received intratumoral injection of Ad.IGFBP7.
|
23319057 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We suggest that SET/TAF-Iα might be a tumor suppressing factor regulated by miR-21-5p in lung adenocarcinoma.
|
31176779 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast to these results, tumor xenografts generated by direct intraosseous injection of LNCaP or C4-2 to bone marrow space resulted in tumors that stained positively for IGFBP-rP1.
|
10383131 |
1999 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Based on above results, we conclude that IGFBP7 plays a potential tumor suppressor role in colorectal carcinogenesis.
|
17312390 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
T1A12/mac25 may therefore have a tumor suppressor-like function and its expression could indicate a disease with a more favorable status, having a better prognosis.
|
9627112 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insulin-like growth factor binding protein 7 (IGFBP7) is known as a tumor suppressor in colorectal cancer (CRC).
|
24427302 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IGFBP-rP1 was down-regulated in primary breast cancer tissues and several breast cancer cell lines but overexpressed in senescent human mammary epithelial cells (HMECs), suggesting that IGFBP-rP1 might be a tumor suppressor in breast cancer and the tumor suppressor role of IGFBP-rP1 might be associated with cellular senescence.
|
22392074 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IGFBP-7 induced the apoptosis of tumor and potentially predicted the clinical outcome in some cancers is further demonstrated.
|
25880247 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interestingly, IGFBP-rP1 showed an inverse association with proliferation (Ki-67%) in estrogen receptor negative tumors as well as in cyclin E high tumors suggesting a separate cell cycle regulatory function for IGFBP-rP1 independent of interaction with the estrogen receptor or the pRb pathway.
|
11429696 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The morphologic and immunohistochemical discrepancies between this intriguing melanotic tumor and other documented renal cell carcinomas bearing identical PSF-TFE3 gene fusion may suggest melanotic Xp11 translocation renal cancer is a distinct entity among the MiT/TFE family neoplasms.
|
19809274 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings suggest a novel molecular mechanism responsible for the tumor suppressive function of IGFBP7 in cisplatin-resistant human lung cancer and could lead to the development of IGFBP7 as a cisplatin-sensitizing agent.
|
22277373 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The markers significantly overexpressed already in earlier tumor stages (pT1-2) of both histological subtypes (n = 19) have been clustered in a "diagnostic signature": PLA2G7, PRAME, MMP1, MMP3, MMP12, LIlRB2, TREM2, CHST2, IGFBP2, IGFBP7, KCNJ8, EMILIN2, CTHRC1, EMR2, WDR72, LPCAT1, COL4A2, CCL4, and SNX10.
|
26631031 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Restoration of IGFBP7 function by the addition of recombinant IGFBP7 (rIGFBP7) induces apoptosis in BRAF-positive human melanoma cell lines, and systemically administered rIGFBP7 markedly suppresses the growth of BRAF-positive primary tumors in xenografted mice.
|
19861408 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We hypothesize that IGFBP-rP1 has a tumor-suppressive effect on prostate cancer growth and its inactivation is through CpG hypermethylation.
|
14633696 |
2003 |