|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have investigated the acute and chronic effect of metrifonate (MTF) and dichlorvos (DDVP), respectively the prodrug and active acetylcholinesterase inhibitor, on the secretory processing of the amyloid precursor protein (APP) in SH-SY5Y neuroblastoma cells.
|
11526466 |
2001 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We also found that the loss of Ate1 in neuroblastoma Neuro-2a cells eliminated the apoptosis-inducing effects of Aβ peptides.
|
31446431 |
2019 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, we gained insight into such interplay by analyzing human SH-SY5Y neuroblastoma cells stably transfected either with wild-type AβPP gene or 717 valine-to-glycine AβPP-mutated gene.
|
22867901 |
2012 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of LRP10 in human neuroblastoma SH-SY5Y cells induces the accumulation of mature APP in the Golgi and reduces its presence at the cell surface and its processing into Aβ, while knockdown of LRP10 expression increases Aβ production.
|
22734645 |
2012 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These observations suggested that nicastrin, as well as the APP and PS proteins, were also involved in the upregulated Bax mediated neuroblastoma cell death and the release of cytochrome c in the neuroblastoma.
|
15370186 |
2004 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
COS-1 cells doubly transfected with cDNAs for N141I mutant PS2 and human beta-amyloid precursor protein (betaAPP) or a C-terminal fragment thereof, as well as mouse Neuro2a neuroblastoma cells stably transfected with N141I mutant PS2 alone, secreted 1.5- to 10-fold more A beta ending at residues 42 (or 43) [A beta42(43)] compared with those expressing the wild-type PS2.
|
9050898 |
1997 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A monoclonal antibody against PN-II (designated mAbP2-1) recognized PN-II in immunoblots of serum-free culture medium from human glioblastoma cells and neuroblastoma cells, as well as in homogenates of normal and Alzheimer's disease brains.
|
2507928 |
1989 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
By utilizing neuroblastoma N2a cells transfected with Swedish mutated human amyloid precursor protein (APP) (N2a/APPswe) and wild-type APP (N2a/APPwt) as cellular models of AD, we examined the alterations of histone acetylation at the promoter regions of PS1 and BACE1 in these cells.
|
25051175 |
2014 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of amyloid precursor protein induces susceptibility to oxidative stress in human neuroblastoma SH-SY5Y cells.
|
15959846 |
2006 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Herein, we found that sulforaphane upregulated Nrf2 expression and promoted Nrf2 nuclear translocation via decreasing DNA methylation levels of the Nrf2 promoter in mouse neuroblastoma N2a cells stably expressing human Swedish mutant amyloid precursor protein (N2a/APPswe cells), a cellular model of AD.
|
29382536 |
2018 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this work, we have shown that activation of the purinergic receptor P2X7 (P2X7R) stimulates sAPPα release from mouse neuroblastoma cells expressing human APP, from human neuroblastoma cells and from mouse primary astrocytes or neural progenitor cells. sAPPα shedding is inhibited by P2X7R antagonists or knockdown of P2X7R with specific small interfering RNA (siRNA) and is not observed in neural cells from P2X7R-deficient mice.
|
21081501 |
2011 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Glial conditioned medium alters the expression of amyloid precursor protein in SH-SY5Y neuroblastoma cells.
|
8297361 |
1994 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the relations between PKR, eIF2α and BACE1 in AD brains in APP/PS1 knock-in mice and in hydrogen peroxide-induced OS in human neuroblastoma (SH-SY5Y) cell cultures.
|
22306812 |
2012 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, we show that the neurotransmitter dopamine stimulates the rapid endocytosis and processing of APP and induces apoptosis in neuroblastoma Neuro2A cells over-expressing transgenic human APP (Swedish mutant).
|
22771396 |
2012 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Transfection of APP-deficient neuroblastoma cells with APP results in increased surface localization of ATP synthase subunit alpha.
|
17726461 |
2008 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In vitro studies further show that PAI-1 increases, whereas TM5275 reduces, Aβ40 level in the culture medium of SHSY5Y-APP neuroblastoma cells.
|
29914038 |
2018 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents.
|
27522594 |
2016 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to examine the ability of GW7647 (a PPAR-α agonist) to regulate amyloid precursor protein (APP) amyloidogenic processing in human neuroblastoma SH-SY5Y cells transfected with APPswe gene.
|
26092426 |
2015 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Furthermore, both HMI-1a3 and HMI-1b11 increased the levels of sAPPα relative to total sAPP and the ratio of Aβ42/Aβ40 in human SH-SY5Y neuroblastoma cells.
|
30138694 |
2018 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Using biochemical, molecular, transmission electron microscopy, immunoblotting and immunofluorescence analyses, we studied the protective effects of ligand 1 against Aβ-induced synaptic and mitochondrial toxicities in mouse neuroblastoma (N2a) cells that express mutant APP.
|
31595293 |
2020 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We here report that the antioxidant N-Acetyl-L-Cystein (NAC) downregulates APP gene transcription in human neuroblastoma cells.
|
11708617 |
2001 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the effect of the familial AD APP (Amyloid precursor protein) K670N/M671L double mutation, APP Swedish mutation (APPswe), on the expression of 5-HT1B, SERT, MAOA, p11 and 5-HT and its metabolite 5-HIAA in SH-SY5Y human neuroblastoma cell line stably transfected with APPswe mutation.
|
25841787 |
2015 |
|
Neuroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A methodology for screening of Abeta modulating drugs was developed utilizing an Abeta-producing neuroblastoma cell line stably transfected with mutant human amyloid precursor protein, immunoprecipitation of Abeta peptides, and mass spectroscopic quantitation of Abeta(1-37)/Abeta(1-38)/Abeta(1-40)/Abeta(1-42) using an Abeta internal standard.
|
19702658 |
2009 |
|
Neuroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein.
|
19679113 |
2009 |
|
Neuroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Over-expression of amyloid precursor protein in Tg2576 transgenic mice and in vitro treatment of SH-SY5Y neuroblastoma cells with the amyloidogenic Aβ42 peptide resulted in a decrease in HNK-1 immunoreactivity levels in brain and cellular extracts, whereas the levels of soluble HNK-1 glycoproteins detected in culture media were not affected by Aβ treatment.
|
26738850 |
2017 |