APP, amyloid beta precursor protein, 351

N. diseases: 485; N. variants: 114
Disease: Plaque, Amyloid ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The 4-kDa beta-amyloid peptide (Abeta), a principal component of parenchymal amyloid deposits in Alzheimer's disease, is derived from amyloid precursor proteins (APP). 8621605 1996
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The main component of senile plaque amyloid is a 39-to 42-amino-acid segment referred to as beta-amyloid, which is derived from amyloid precursor protein (APP). 8809275 1996
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE In this report, we demonstrate that transgenic animals that coexpress a FAD-linked human PS1 variant (A246E) and a chimeric mouse/human APP harboring mutations linked to Swedish FAD kindreds (APP swe) develop numerous amyloid deposits much earlier than age-matched mice expressing APP swe and wild-type Hu PS1 or APP swe alone. 9354339 1997
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 AlteredExpression disease BEFREE Models of AD include: aged monkeys that show both cognitive/memory deficits and cellular abnormalities (amyloid deposition/cytoskeletal abnormalities of neurons) in cortex and hippocampus; and Tg mice that express mutant human FAD-linked genes (i.e., APP and PS1) and show increased levels of A.42, amyloid deposits, dystrophic neurites, and local responses of astrocytes and microglia. 9683997 1997
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The increased expression and/or abnormal processing of the amyloid precursor protein (APP) is associated with the formation of amyloid plaques and cerebrovascular amyloid deposits, which are one of the major morphological hallmarks of Alzheimer's disease (AD). 9775403 1998
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The amyloid precursor protein (APP) has been associated with Alzheimer's disease (AD) because APP is processed into the beta-peptide that accumulates in amyloid plaques, and APP gene mutations can cause early onset AD. 10037734 1999
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE The transmembrane domain and a portion of the C-terminus (A beta) of the amyloid precursor protein, are known to form the nucleus of the amyloid plaque. 10192224 1999
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Here, we describe significant CAA in addition to amyloid plaques, in aging APP/Ld transgenic mice overexpressing the London mutant of human amyloid precursor protein (APP) exclusively in neurons. 11021833 2000
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE The central component of senile amyloid plaques in Alzheimer's disease (AD) is the beta-amyloid peptide (Abeta), derived from proteolytic processing of the amyloid precursor protein (APP). 11421596 2001
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Transgenic designs emphasizing amyloid precursor protein produced mice that develop amyloid plaques, but neurodegeneration and neurofibrillary tangles failed to form. 11917160 2002
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE It is also possible that the human APP gene responsible for HSD-10 deposition in APs of these Tg2576 mice brains is different from that of AD brains. 12393239 2002
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 AlteredExpression disease BEFREE To study the effect of amyloid deposits on cell cycle related events in vivo, the expression of cell cycle markers was examined by immunohistochemistry in amyloid precursor protein (APP) transgenic mice (APP23 mice, Swedish double mutation). 12923647 2003
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE Exploratory activity and spatial learning in 12-month-old APP(695)SWE/co+PS1/DeltaE9 mice with amyloid plaques. 16169151 2005
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE In addition, for animals older than 12 months, we confirmed our previous report that only the two genotypes that form amyloid plaques (APP and PS/APP) have significantly reduced T(2) values compared with NTg controls. 17451178 2007
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE A novel magnetic resonance (MR) imaging contrast agent based on a derivative of human amyloid beta (Abeta) peptide, Gd[N-4ab/Q-4ab]Abeta 30, was previously shown to cross the blood-brain barrier (BBB) and bind to amyloid plaques in Alzheimer's disease (AD) transgenic mouse (APP/PS1) brain. 17505020 2007
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE We conclude that the simultaneous presence of human mutated Tau(VLW) and plaque-amyloid (and/or APP(SW)) potentiates and anticipates tau phosphorylation at the 12E8 epitope, intensifying pyramidal neuron immunostaining and tau filament formation in this double-transgenic model. 18679696 2008
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Furthermore, Alzheimer's amyloid precursor protein, which accumulates within the axonal swellings under pathological conditions, co-accumulated with the PrP-amyloid plaques. 18751990 2008
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease CTD_human Up-regulated expression of amyloid precursor protein (APP) occurs early in the cascade of events that leads to amyloid plaque formation in the human brain. 19818510 2009
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE Tg19959 mice carry human APP with two mutations and develop amyloid plaques and memory impairment starting at 3-4 months of age. 19914323 2010
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE The APP(E693Q) mice did not develop amyloid plaques at any age studied, up to 30 months. 20641005 2010
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice. 20813165 2010
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Chronic treatment with the α2-adrenoceptor antagonist fluparoxan prevents age-related deficits in spatial working memory in APP×PS1 transgenic mice without altering β-amyloid plaque load or astrocytosis. 20850464 2011
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 GeneticVariation disease BEFREE Collectively, our results suggest that different pathological mechanisms, namely an intracellular accumulation of APP or extracellular amyloid plaques, may lead to spine abnormalities in young adult APP23 and deltaE9 mice, respectively. 25862638 2015
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 Biomarker disease BEFREE Cleavage of APP leads to formation of β-amyloid plaque, which is a hallmark of Alzheimer's disease (AD). 28628788 2017
CUI: C2936349
Disease: Plaque, Amyloid
Plaque, Amyloid 		0.400 AlteredExpression disease BEFREE Mouse models using APP-transgene overexpression to generate amyloid plaques have shown to model only certain parts of the disease. 28637503 2017