|
Mental deterioration
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We found a coding mutation (A673T) in the APP gene that protects against Alzheimer's disease and cognitive decline in the elderly without Alzheimer's disease.
|
22801501 |
2012 |
|
Mental deterioration
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The study suggests that both HIIT and MICT alleviate cognitive decline and down-regulat Aβ level in the hippocampus in APP/PS1 transgenic mice, which may be mediated by improvements in mitochondrial morphology and dynamics.
|
31445975 |
2019 |
|
Mental deterioration
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We report a novel missense mutation, D678H, in the APP gene in a Taiwanese patient who had progressive cognitive decline beginning in middle age.
|
23931937 |
2014 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
CTD_human |
Exposure to As-, Cd-, and Pb-mixture induces Aβ, amyloidogenic APP processing and cognitive impairments via oxidative stress-dependent neuroinflammation in young rats.
|
25288670 |
2015 |
|
Mental deterioration
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
Since interleukin-1 (IL-1) is an APP gene promoter showing a progressive increase in body fluids in parallel with mental deterioration in AD patients, we have studied the effects of CDP-choline on cognition, several biological parameters, and IL-1 beta production in AD and multi-infarct dementia (MID) in order to elucidate whether this compound alone or in combination with other drugs is able to restore immune function and improve mental performance in senile dementia.
|
8239305 |
1993 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
MT5-MMP emerges as a new pro-amyloidogenic regulator of APP metabolism, whose deficiency alleviates amyloid pathology, neuroinflammation and cognitive decline.
|
26202697 |
2016 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
M344 also increases levels of immature APP, supporting an effect on APP trafficking, concurrent with the observed increase in MINT2 and FE65, both shown to increase immature APP in the early secretory pathway.Chronic i.p. treatment of the triple transgenic (APP<sub>sw</sub>/PS1<sub>M146V</sub>/Tau<sub>P301L</sub>) mice with M344, at doses as low as 3 mg/kg, significantly prevented cognitive decline evaluated by Y-maze spontaneous alternation, novel object recognition, and Barnes maze spatial memory tests.
|
29073110 |
2017 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
We hypothesize that the functional loss of members of the APP family contributes to the gradual cognitive decline in Alzheimer's disease patients.
|
10578233 |
1999 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The actions of PGA1 on the production and deposition of Aβ ultimately improved the cognitive decline of the amyloid precursor protein/presenilin1 (APP/PS1) transgenic mice.
|
30627958 |
2019 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Platelets contain more than 95% of the circulating APP and implicate as a candidate biomarker for cognitive decline.
|
29775888 |
2018 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Treadmill Exercise Decreases Aβ Deposition and Counteracts Cognitive Decline in APP/PS1 Mice, Possibly <i>via</i> Hippocampal Microglia Modifications.
|
31024293 |
2019 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results offer additional support for the negative impact of apoE4 on both memory and attention and further suggest that APP-Yac/apoE-TR mice provide a novel and useful model for investigating the role of apoE in mediating susceptibility to cognitive decline.
|
20002203 |
2010 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
The high accumulation of the CB-RBCMs in neurons resulted in a decrease in the neurotoxicity of CB and an increase in the migratory activity of neurons, and alleviated cognitive decline in APP/PS1 transgenic (Tg) mice.
|
28865290 |
2017 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Mid infrared light treatment attenuates cognitive decline and alters the gut microbiota community in APP/PS1 mouse model.
|
31831179 |
2020 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Genetic variability at APOE and APP was not significantly associated with evidence of cognitive decline.
|
9189907 |
1997 |
|
Mental deterioration
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
In this study, we investigated the effect of T4 on cognitive decline and synaptic plasticity in five times familial AD (5XFAD) mice co-expressing mutated amyloid precursor protein and presenilin-1.
|
25661995 |
2015 |
|
Mental deterioration
|
0.400 |
AlteredExpression
|
phenotype |
BEFREE |
The results suggest interaction between chronic cerebral hypoperfusion and APP(Sw/Ind) overexpression in cognitive decline in mice through enhanced neuronal loss and altered amyloid β metabolism.
|
21305033 |
2011 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
Progressive neuropathology and cognitive decline in a single Arctic APP transgenic mouse model.
|
19329229 |
2011 |
|
Mental deterioration
|
0.400 |
Biomarker
|
phenotype |
BEFREE |
These results suggest that normal aging may be associated with enhanced neuroinflammation, oxidative stress, and cognitive decline, however distinctions are apparent in the brain of APP/PS1 mice in terms of inflammation and insulin signaling and in certain cognitive domains.
|
29604345 |
2018 |
|
Mental deterioration
|
0.400 |
GeneticVariation
|
phenotype |
BEFREE |
We found a novel APP mutation (A673V) in the homozygous state in a patient with early-onset AD-type dementia and in his younger sister showing initial signs of cognitive decline.
|
22727994 |
2012 |