|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Brachydactyly type A1 (BDA1, OMIM 112500) is a rare inherited malformation characterized primarily by shortness or absence of middle bones of fingers and toes.
|
30651074 |
2019 |
|
Deformity
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Brachydactyly type A1 (BDA1, OMIM 112500) is a rare inherited malformation characterized primarily by shortness or absence of middle bones of fingers and toes.
|
30651074 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Patients with lung squamous cell carcinoma (P=0.037) and adenocarcinoma (P=0.001) with positive Ihh protein expression survived significantly shorter than patients with negative Ihh protein expression.
|
27801732 |
2018 |
|
Squamous cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of WIF-1 and Ihh protein in 74 squamous cell carcinomas and 76 adenocarcinomas was measured by immunohistochemistry.
|
27801732 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
For non-IUGR and IUGR rats, this study design resulted in three diet groups: offspring from dams fed a regular diet and weaned to a regular diet (NRR and IRR), offspring rats from dams fed an HFD and weaned to a regular diet (NHR and IHR) and offspring from dams fed an HFD and weaned to an HFD (NHH and IHH).
|
29397052 |
2018 |
|
Nephrocalcinosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Increased awareness of the typical symptoms of hypercalcemia, such as anorexia, polydipsia, vomiting and failure to thrive, is of utmost importance in diagnosing IHH early and preventing long-term complications such as nephrocalcinosis.
|
28874334 |
2018 |
|
Squamous cell carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with lung squamous cell carcinoma (P=0.037) and adenocarcinoma (P=0.001) with positive Ihh protein expression survived significantly shorter than patients with negative Ihh protein expression.
|
27801732 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The percentage of positive WIF-1 protein expression was significantly higher, while positive Ihh protein expression was significantly lower in patients with well-differentiated lung squamous cell carcinoma and adenocarcinoma, tumor node metastasis (TNM) stage I disease, and lymph node metastasis than that in patients with poorly differentiated tumor, TNM stage III disease, and lymph node metastasis (P<0.05, <0.01).
|
27801732 |
2018 |
|
SHORT STATURE WITH NONSPECIFIC SKELETAL ABNORMALITIES
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our study demonstrated the association of pathogenic variants in IHH with short stature with nonspecific skeletal abnormalities and established a frequent cause of growth disorder, with a preliminary good response to rhGH.
|
29155992 |
2018 |
|
Craniosynostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Even in the absence of <i>Ihh, Gli3</i> deletion was sufficient to induce aberrant precocious ossification across the developing suture, indicating that the craniosynostosis phenotype of <i>Gli3</i><sup><i>Xt</i>-<i>J</i>/<i>Xt</i>-<i>J</i></sup> mice is not dependent on IHH ligand.
|
29311969 |
2017 |
|
Synkinesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In a clinical sense, recognizing those IHH genes and associated phenotypes may improve our diagnostic capabilities by enabling us to prioritize the screening of particular gene(s) such as synkinesia (ANOS1), dental agenesis (FGF8/FGFR1) and hearing loss (CHD7).
|
29280744 |
2017 |
|
Developmental absence of tooth
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a clinical sense, recognizing those IHH genes and associated phenotypes may improve our diagnostic capabilities by enabling us to prioritize the screening of particular gene(s) such as synkinesia (ANOS1), dental agenesis (FGF8/FGFR1) and hearing loss (CHD7).
|
29280744 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
The present investigation examines the capacity of co-cultures between the HCEC colon epithelial cells and the HCT-116 colorectal cancer cells (mimicking the primary site of tumour growth) and between IHH hepatocytes and the HCT-116 colorectal cancer cells (metastatic site) to influence the effects of NAMI-A (imidazolium trans-imidazoledimethylsulphoxidetetrachloro ruthenate) on the tumour cells themselves.
|
28064102 |
2017 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, DKK1 and FRZB negatively correlated with OA grading, while RUNX2 and IHH showed a significantly positive correlation with OA grading.
|
27428952 |
2016 |
|
Congenital heart disease
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A de novo 2q35-q36.1 deletion incorporating IHH in a Chinese boy (47,XYY) with syndactyly, type III Waardenburg syndrome, and congenital heart disease.
|
27966732 |
2016 |
|
47, XYY syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A de novo 2q35-q36.1 deletion incorporating IHH in a Chinese boy (47,XYY) with syndactyly, type III Waardenburg syndrome, and congenital heart disease.
|
27966732 |
2016 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We also analyzed levels of IHH messenger RNA and expression of IHH gene targets in intestinal tissues from patients with familial adenomatous polyposis (n = 18) or sessile serrated adenomas (n = 15) and normal colonic tissue from control patients (n = 12).
|
25307863 |
2015 |
|
Adenomatous Polyposis Coli
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We also analyzed levels of IHH messenger RNA and expression of IHH gene targets in intestinal tissues from patients with familial adenomatous polyposis (n = 18) or sessile serrated adenomas (n = 15) and normal colonic tissue from control patients (n = 12).
|
25307863 |
2015 |
|
Craniosynostosis, Philadelphia Type
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We subsequently screened additional genes in the probands with no detected mutation: one duplication of the IHH regulatory region was identified in a patient with craniosynostosis Philadelphia type and five variants, four novel, were identified in the recently described TCF12, in probands with coronal or multisuture affectation.
|
25271085 |
2015 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The tumorigenic cell line HuH7 together with the non-tumorigenic cells IHH and the human pluripotent stem cell derived hepatocytes (hPSC-H), were used as cellular models of HCC and normal liver cells, respectively.
|
25742740 |
2015 |
|
Ewings sarcoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, ES samples showed a low IGF2 gene expression (p<0.0001) and high IHH (p<0.0001), PTCH1 (p=0.0173) and GLI1 (p=0.0113) gene expressions.
|
24846856 |
2014 |
|
Prolactinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We report a female with combined pituitary hormone deficiencies (GH, TSH, gonadotropin and ACTH), except for prolactin, as a consequence of PROP1 mutation, and a male with KS (anosmia and IHH) due to Kal 2 gene (fibroblast growth factor receptor 1- FGFR1) mutation, both of whom in adulthood presented with prolactinomas.
|
22801565 |
2013 |
|
Hyperplastic Polyp
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
IHH promoter methylation was frequently observed in colorectal adenomas (55.2%, p = 0.004) and CRCs (70.6%, p<0.001) compared with that in hyperplastic polyps (11.8%).
|
20854074 |
2010 |
|
Class III malocclusion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These genes, which include Indian hedgehog homolog (IHH), parathyroid-hormone like hormone (PTHLH), insulin-like growth factor-1 (IGF-1), and vascular endothelial growth factor (VEGF), and variations in their levels of expression play an important role in the etiology of Class III malocclusion.
|
20477965 |
2010 |
|
Biliary Tract Cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data thus implicate a direct role of IHH in the carcinogenesis of BTC with APBDJ.
|
19793350 |
2010 |