|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Heterozygous mutations in CD95, CD95 ligand or caspase-10 underlie most cases of autoimmune lymphoproliferative syndrome (ALPS), a human disorder that is characterized by defective lymphocyte apoptosis, lymphadenopathy, splenomegaly and autoimmunity.
|
12353035 |
2002 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Fas (CD95, APO-1) mutations were found in autoimmune diseases and some lymphomas, suggesting impairment of Fas-mediated cell death signaling that may cause tumor development.
|
11454987 |
2001 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the autoimmune/lymphoproliferative syndrome (ALPS), inherited loss-of-function mutations of the Fas gene cause nonmalignant lymphoproliferation and autoimmunity.
|
10807785 |
2000 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Apoptosis mediated by the Apo-1/Fas and Fas ligand pathways has been implicated in many disorders, including autoimmunity and tumorigenesis.
|
10840834 |
2000 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Heterozygous mutations of the receptor CD95 (Fas/Apo-1) are associated with defective lymphocyte apoptosis and a clinical disease characterized by lymphadenopathy, splenomegaly, and systemic autoimmunity.
|
9927496 |
1999 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CD95 mutations are associated with loss of regulation of B lymphocytes, which predisposes to systemic autoimmunity including SLE.
|
10513797 |
1999 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
As expected, the primary genetic determinant of autoimmune disease in this cross was the Fas gene on mouse chromosome 19, exhibiting a lod score of 60.
|
9862736 |
1998 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Our knowledge in immunology has been dramatically increased by several excellent investigations elucidating the role of the Fas (Apo-1/CD95) receptor/ligand (FasL) system in complex immunological processes such as the acquisition of self tolerance in T cells, progression of autoimmunity, clonal deletion of activated T cells, B-cell regulation and the establishment of "immune privileged" sites such as testis or retina.
|
9922038 |
1998 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Fas/APO-1/CD95 in health and autoimmune disease: thymic and peripheral aspects.
|
9826578 |
1998 |
|
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The cell surface protein Fas (CD95) and its ligand play a pivotal role in regulating lymphocyte apoptosis, and defective expression of either Fas or Fas ligand results in marked over accumulation of mature lymphocytes and autoimmune disease in mice.
|
9028957 |
1997 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Deficiency of the Fas apoptosis pathway without Fas gene mutations in pediatric patients with autoimmunity/lymphoproliferation.
|
9108407 |
1997 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Fas gene mutations in the Canale-Smith syndrome, an inherited lymphoproliferative disorder associated with autoimmunity.
|
8929361 |
1996 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Heterozygous fas gene mutations, like homozygous deletions, can also be expressed in various cells and tissues and may predispose towards autoimmune disorders.
|
8806292 |
1996 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Stimulation of PIP2 hydrolysis by aluminum fluoride in resting T cell subsets of normal and autoimmune-prone lpr mice.
|
2545777 |
1989 |