|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Collectively, our data suggest that microvesicles packaging IL-1β and TNF-α enhance lung inflammation in VILI.
|
30075431 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
While IFN-γ, IL-2, and TNF-α have been previously noted, the finding of elevated levels of the innate cytokines GM-CSF and IL-1β could suggest that these, as well as IL-13, are early and specific markers for pulmonary coccidioidomycosis.<b>IMPORTANCE</b> Coccidioidomycosis, commonly known as Valley fever, is a common pneumonia in the southwestern United States.
|
29769377 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In vivo studies revealed that the indicators of pulmonary inflammation (pathology, inflammatory cell numbers) and related cytokines (IL-1β, IL-6, IL-33) mRNA expressions in CD11c-Map3k7<sup>-/-</sup> animals were significantly lower than wild-type animals after mice were instilled particles.
|
31330343 |
2019 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
LHGDN |
Enhanced IL-1beta-induced IL-8 production in cystic fibrosis lung epithelial cells is dependent of both mitogen-activated protein kinases and NF-kappaB signaling.
|
17420005 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
CTD_human |
Expansion of CD4(+) CD25(+) and CD25(-) T-Bet, GATA-3, Foxp3 and RORγt cells in allergic inflammation, local lung distribution and chemokine gene expression.
|
21625544 |
2011 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
RGD |
Early gestational intrauterine infection induces postnatal lung inflammation and arrests lung development in a rat model.
|
20476872 |
2011 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome mediates interleukin-1β production in immune cells in response to Acinetobacter baumannii and contributes to pulmonary inflammation in mice.
|
28032341 |
2017 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Neutralization of both IL-1α/IL-1β plays a major role in suppressing combined cigarette smoke/virus-induced pulmonary inflammation in mice.
|
28315490 |
2017 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results showed an alleviated pulmonary inflammation and fibrosis in myeloid differentiation primary response gene 88 (MyD88)-deficient mice treated with bleomycin (BLM), accompanied with a reduced TGF-β signaling and production of pro-fibrotic cytokines, including TNF-α, IL-1β.
|
28662409 |
2017 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
LHGDN |
Increased levels of pro-inflammatory cytokines, such as interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha), have been correlated with lung inflammation.
|
17681786 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the influence of LPS-induced production of IL-1β and Rev-erbα on the development of lung inflammation.
|
31129418 |
2019 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The efficient attenuation of BLM-induced lung inflammation and fibrosis was determined in RIPK3 knockout mice and by necrostatin-1 with a concomitant reduction in high-mobility group box 1 and IL-1β.
|
29444413 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Mice deficient for chromosome 3 GBPs were unable to mount a rapid IL-1/chemokine (C-X-C motif) ligand 1 (CXCL1) response during Legionella-induced pneumonia, with defective bacterial clearance.
|
29972777 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung.
|
15668323 |
2005 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The recombinant VPA/3446 virus also caused more severe pneumonia in Casp 1(-/-) mice than in IL1β(-/-) and wild-type B6 mice.
|
23901080 |
2013 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, IL-1β-induced pulmonary inflammation in early life causes a chronic lung disease in adulthood.
|
29446321 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that TLMPs trigger inflammasome activation and IL-1β production in bronchial and alveolar epithelial cells to induce airway and lung inflammation.
|
31759058 |
2020 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, bleomycin-induced lung pathology required the inflammasome and IL-1R1/MyD88 signaling, and IL-1 represented a critical effector of pathology and therapeutic target of chronic lung inflammation and fibrosis.
|
17992263 |
2007 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The faster growing strains elicited more tumor necrosis factor α and interleukin 1β than the slower growing strains, even after heat killing, and caused accelerated death of infected guinea pigs (∼9 weeks vs 24 weeks) associated with increased lung inflammation/pathology.
|
22315279 |
2012 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Interleukin 1B (IL1B) is involved in pulmonary inflammation induced by environmental or occupational toxins.
|
20035239 |
2010 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
A single GLA exposure (1 mg/kg) induced seizures and inflammatory cell recruitment in the broncho-alveolar space, and increased myeloperoxidase (MPO), inducible NO synthase (iNOS), interstitial inflammation and disruption of alveolar septae within 6-24 h. Interleukin 1β (IL-1β) was increased and lung inflammation depended on IL-1 receptor 1 (IL-1R1).
|
27549113 |
2016 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
To study the hypothesis that MMP-9 is an important downstream mediator in IL-1 beta-induced lung injury in the newborn, we compared the effects of IL-1 beta on fetal and postnatal lung inflammation and development in transgenic mice with regulatable pulmonary overexpression of human mature IL-1 beta with wild-type (IL-1 beta/MMP-9(+/+)) or null (IL-1 beta/MMP-9(-/-)) MMP-9 loci.
|
19097983 |
2009 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
The severity of pneumonia in mice caused by haze particulate was determined through imaging the activity of LTA<sub>4</sub>H as biomarker and confirmed using a commercial ELISA kit of interleukin-1β.
|
29682967 |
2018 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
TNB instillations in IL-1R null mice demonstrated the critical role of IL-1β in initiation of TNB-induced lung inflammation.
|
25179214 |
2014 |
|
Pneumonia
|
0.600 |
Biomarker
|
disease |
BEFREE |
Importantly, blocking of IL-1β with either a specific antibody or a recombinant IL-1 receptor ameliorated the pulmonary inflammation.
|
29228045 |
2017 |