|
Colitis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, key cytokines associated with colitis (IL-1β, IL-6, and IL-17A) were significantly suppressed, following treatment with M2b macrophage exosomes.
|
31749791 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The synthesis of LL-37 was enhanced with butyrate (a product of bacterial fermentation) and interleukin-1β (IL-1β) (a proinflammatory cytokine in colitis) in the presence of exogenously added purified MUC2.
|
28069814 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here we further investigated the anti-inflammatory effect of compound 1 in DSS-induced colitis in C57BL/6 and NLRP3(-/-) mice, and revealed the possible modulation by compound 1 of NLRP3 inflammasome-mediated IL-1β release from macrophages.
|
26588861 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Either exogenous IL-1β or IL-18 ameliorated the colitis with or without reduction in Th2 cytokine expression, respectively.
|
27966619 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Furthermore, ZFE effectively modulated the mRNA expression of redox-sensitive transcription factors, such as nuclear factor (erythroid-derived 2)-like 2 and heme oxygenase-1, downregulated the expression of p38 mitogen-activated protein kinase, and upregulated that of vascular endothelial growth factor A and interleukin-1β in AcOH-induced colitis in rats.
|
29518435 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We showed worsened colonic inflammation in Atg16l1 deficiency mice in DSS induced murine colitis with increased proinflammatory cytokines of IL-1β and TNF-α.
|
28390705 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The clinical relevance of these findings was assessed by treating CGD patients who had severe colitis with IL-1 receptor blockade using anakinra.
|
24550444 |
2014 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
All-trans retinoic acid cotreatment (1 mg/kg BW, i.p. daily) of DSS-treated mice (3% in drinking water for 7 days) alleviated colitis-associated weight loss, diarrheal phenotype, and induction of IL-1β and CXCL1 and a decrease in DRA mRNA and protein levels in the colon.
|
31634391 |
2020 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Seventy-two hours following colitis induction, macroscopic and microscopic mucosal lesions, and the colonic levels of tumor necrosis factor-alpha (TNF-α) and interleukin-1β (IL-1β) were determined.
|
30318564 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Blockade of IL-1β activity by treatment with IL-1R antagonist (IL-1Ra; Anakinra) inhibited colitis acceleration in TLR2/MDR1A double deficiency; intestinal CD11b(+)Ly6C(+)-derived IL-1β production and inflammation entirely depended on MyD88.
|
23636052 |
2013 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Cytokines, specifically IL-4 and IL-1, also play an important role in the development of colitis in TCR alpha-/- mice.
|
10723681 |
2000 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Here, we show that ISR activation by arsenite (Ar) results in suppression of IL-1β production in macrophages and inhibition of DSS-induced colitis in a murine model through a novel posttranscriptional and translation regulatory (PTR) mechanism.
|
30578631 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
In consistence with these results, COMMD10-deficiency in Ly6C<sup>hi</sup> monocytes, but not in intestinal-resident lamina propria macrophages, led to increased IL-1β production and aggravated colonic inflammation in a model of DSS-induced colitis.
|
30487795 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
DAI evaluation, colon length, colon tissue morphology, histologic damage scores and relative protein concentrations (MPO, TNF-α and IL-1β) demonstrated that the Alg/Chi/IL-1Ra microcapsules alleviated DSS-induced colitis in mice.
|
30779979 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
This study was performed in rats with dinitrobenzenesulfonic acid (DNBS)-induced colitis, to investigate how the direct blockade of NLRP3 inflammasome with an irreversible inhibitor (INF39) compares with Ac-YVAD-cmk (YVAD, caspase-1 inhibitor) and anakinra (IL-1β receptor antagonist), acting downstream on NLRP3 signaling.
|
30559669 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1β Production and to Prevent DSS-Induced Colitis in Mice.
|
28614718 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
CTD_human |
Elevation of serum IL-1β level due to colitis was also attenuated by both treatments.
|
23810507 |
2013 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The present study was to investigate the protective effects of curcumin on dextran sulfate sodium (DSS)-induced colitis through inhibiting NLRP3 inflammasome activation and IL-1β production.
|
30396035 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
The molecular characterization resulted in identification of Il1β as the major elevated cytokine during early phases of colitis.
|
28796256 |
2017 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
We demonstrated that innate immune production of IL1β mediates colitis in IL10R-deficient mice.
|
27693323 |
2016 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, we have identified a dual role for myeloid PTPN2 in directly regulating inflammasome activation and IL-1β production to suppress pro-inflammatory responses during colitis but promote intestinal tumor development.
|
29444435 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
<b>Materials and Methods:</b> Healthy human colonic mucosal strips (4 × 10 mm) were incubated in carbogenated culture medium at 37°C for 16 h. Proinflammatory cytokines TNFα and IL-1β (each 10 ng/mL) were used to induce colitis in mucosal strips, and the effects of Panx1 and P2X7R on cytokines-induced tissue damage were determined in the presence of the Panx1 channel blocker <sup>10</sup>Panx1 (100 μM) and P2X7R antagonist A438079 (100 μM).
|
30127744 |
2018 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
NLRP3 inflammasome has been reported to be associated with inflammatory bowel disease including colitis due to its potential ability to induce IL-1β secretion.
|
30901677 |
2019 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
RGD |
Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis.
|
22969190 |
2012 |
|
Colitis
|
0.600 |
Biomarker
|
disease |
BEFREE |
PAP-1 also reduced the expression of Kv1.3, iNOS, NLRP3, caspase-1p20 and IL-1β on macrophages in colitis mice.
|
31351364 |
2019 |