Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IL-1 family member cytokine IL-36γ is recognised as key mediator in the immunopathology of psoriasis, hallmarks of which involve the activation of both resident and infiltrating inflammatory myeloid cells and aberrant angiogenesis.
|
29535706 |
2018 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We tested their effectiveness in the treatment of psoriasis in order to further investigate the potential topical anti-inflammatory activity of polyphenols by means of a randomized, double-blind, placebo-controlled add-on clinical trial, after having examined their ability to downregulate the expression of IL-1β cytokine in monocyte/macrophage primary cell culture.
|
29441952 |
2018 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to investigate the expression of NLRP3 in psoriasis biopsy samples and to assess the possible correlation of its expression with that of interleukin IL-1β and Caspase-1.
|
30393369 |
2018 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The results suggest that genetic variants related to increased IL-1β levels may be unfavorable when treating psoriasis with either anti-TNF or ustekinumab, whereas genetic variants related to high interferon-γ levels may be favorable when treating psoriasis with ustekinumab.
|
28696418 |
2018 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The compounds reported herein may have utility as lead compounds for the development of inhibitors of elastase-mediated activation of IL-36 and other IL-1 family cytokines in inflammatory conditions, such as psoriasis.
|
29744290 |
2018 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
We observed that keratinocytes were primed to secrete IL-1β when cultured in conditions mimicking psoriasis.
|
30571969 |
2019 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
For example, in asthma, both IL-33 and IL-1 are of major importance, as are IL-36 and IL-1 in psoriasis.
|
31427775 |
2019 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
A Critical Role of the IL-1β-IL-1R Signaling Pathway in Skin Inflammation and Psoriasis Pathogenesis.
|
30120937 |
2019 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
The IL-1 super-family of cytokines and receptors is highly pleiotropic and plays a fundamental role in the pathogenesis of several auto-inflammatory conditions including rheumatoid arthritis, multiple sclerosis and psoriasis.
|
31231388 |
2019 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Proteomic panels revealed IL-6 as a top differentially expressed cytokine in psoriasis with pathway analysis highlighting IL-1β ( Z score 3.7; P=1.02×10<sup>-23</sup>) as an upstream activator of the observed upregulated proteins.
|
30760013 |
2019 |
Psoriasis
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Lesional skin of 10 patients with recent onset, untreated psoriasis has been investigated for expression of IL-1β, IL-17, IL-23 and other cytokines involved in the disease in comparison with normal skin of 10 healthy controls using a protein array method.
|
31509228 |
2019 |
Psoriasis
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-1 and IL-33 are cytokines found to be implicated in many inflammatory disorders including rheumatoid arthritis, atherosclerosis and psoriasis.
|
30574739 |
2019 |