|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
High-sensitivity C-reactive protein (hs-CRP), interleukin-1β (IL-1β), IL-6, tumor necrosis factor-α (TNF-α), and chemokine (C-X-C motif) ligand 8 (CXCL8) were measured in plasma at age 6 months (N = 214) and 7 years (N = 277) in children from the Copenhagen Prospective Studies on Asthma in Childhood<sub>2000</sub> (COPSAC<sub>2000</sub> ) birth cohort.
|
27992959 |
2017 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evidenced a new locus in the 16q12 region (near cylindromatosis turban tumor syndrome gene [CYLD]) and confirmed 4 asthma risk regions: 2q12 (IL-1 receptor-like 1 [IL1RL1]), 6p21 (HLA-DQA1), 9p24 (IL33), and 17q12-q21 (zona pellucida binding protein 2 [ZPBP2]-gasdermin A [GSDMA]).
|
27130862 |
2016 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-1β and IL-8 protein levels were significantly increased in sputum of patients with severe asthma and were positively associated with sputum neutrophilia.
|
27155035 |
2016 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this subnetwork, several receptors (EGFR, EGR1, ESR2, PGR), transcription factors (MYC, JAK), cytokines (IL8, IL6, IL1B), one chemokine (CXCL1), one kinase (SRC) and one cyclooxygenase (PTGS2) were described to be associated with inflammatory environment and steroid resistance in asthma.
|
27188427 |
2016 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Airway IL-1β and Systemic Inflammation as Predictors of Future Exacerbation Risk in Asthma and COPD.
|
25950204 |
2015 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Confluent, serum-starved ASM cells from donors with and without asthma were stimulated with IL-1β and T-helper (Th)1 (TNFα and IFNγ) or Th2 (IL-4, IL-13) cytokines, or left unstimulated.
|
24588865 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The most recent work in systems biology and asthma has occurred in the area of genomics (e.g., pharmacogenomics and gene-environment interactions), protein interaction networks [e.g., interleukin (IL)-33/IL-1 receptor-like 1 signaling], cluster analysis of asthma patients (e.g., application of severe asthma research program clusters to a general urban asthma population), and multiscale approaches to asthma encompassing data from the molecule to whole organ (e.g., modeling of airways hyperresponsiveness).
|
24275925 |
2014 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma.
|
25278425 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In 2 birth cohorts, the Prevalence and Incidence of Asthma and Mite Allergy (PIAMA) study and Avon Longitudinal Study of Parents and Children (ALSPAC), we analyzed associations of longitudinal wheezing phenotypes and asthma with single nucleotide polymorphisms (SNPs) of 8 genes encoding IL-33, IL1RL1, its coreceptor IL1RAcP, its adaptors myeloid differentiation primary response gene 88 (MyD88) and Toll-IL-11 receptor domain containing adaptor protein (TIRAP), and the downstream IL-1 receptor-associated kinase 1, IL-1 receptor-associated kinase 4, and TNF receptor-associated factor 6 (TRAF6).
|
24568840 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A signature of 6 genes, including Charcot-Leydon crystal protein (CLC); carboxypeptidase A3 (CPA3); deoxyribonuclease I-like 3 (DNASE1L3); IL-1β (IL1B); alkaline phosphatase, tissue-nonspecific isozyme (ALPL); and chemokine (C-X-C motif) receptor 2 (CXCR2), was reproducible and could significantly (P < .0001) discriminate eosinophilic asthma from other phenotypes, including patients with noneosinophilic asthma (AUC, 89.6%), paucigranulocytic asthma (AUC, 92.6%), or neutrophilic asthma (AUC, 91.4%) and healthy control subjects (AUC, 97.6%), as well as discriminating patients with neutrophilic asthma from those with paucigranulocytic asthma (AUC, 85.7%) and healthy control subjects (AUC, 90.8).
|
24582314 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The abundance of cyclooxygenase-2 (COX-2) and IL-1β is negatively regulated by the miR-146 family, suggesting miR-146a and/or miR-146b might modulate inflammatory mediator expression in airway smooth muscle thereby contributing to pathogenesis of asthma.
|
25217662 |
2014 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-33 is an IL-1 family cytokine which signals via its T1/ST2 receptor, and acts as a key regulator of inflammation, notably the type-2 response implicated in asthma.
|
23855553 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with these data, pretreatment with the TNF-α inhibitor etanercept but not the IL-1β receptor inhibitor anakinra prevented parathion-induced airway hyperreactivity and protected M2 receptor function.
|
23377347 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because asthma exacerbations are associated with elevated concentrations of secreted IL-1β, we addressed whether the NLRP3 inflammasome is activated under in vitro conditions that mimic infectious exacerbations in asthma.
|
23614732 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our data show that the presence of SNPs in IL12B, TNFA, and IL1B was significantly associated with asthma, atopy, and severity of asthma.We also highlight the importance of genetic context, haplotype, and gene-gene interaction analysis in genetic association studies.
|
24654313 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
High risk association of IL-1 receptor antagonist (IL-1RN) VNTR polymorphism with asthma in a North Indian population: a pilot study.
|
23602199 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Lung cancer risk also increased with the number of polymorphism sites where at least 1 'risk' allele was present [interleukin 1-β -31T/C (T allele), IL1RN (*2 allele) and IL6-634C/G (G allele)] among those with asthma, cough or atopy (Ptrend 0.001) but not in those without (Ptrend 0.47).
|
21252117 |
2011 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
IL-33 is a recently characterized IL-1 family cytokine and found to be expressed in inflammatory diseases, including severe asthma and inflammatory bowl disease.
|
20689814 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Interleukin-1beta (IL-1beta) and basic fibroblast growth factor (bFGF) are important regulators of proliferation, and their expression is increased in lungs of patients with asthma, idiopathic pulmonary fibrosis (IPF), or chronic obstructive pulmonary disease (COPD).
|
20082309 |
2010 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The discovery that the IL-1RI-IL-1 and ST2-IL-33 pathways are crucial for allergic inflammation has raised interest in these receptors as potential targets for developing new therapeutic strategies for bronchial asthma.
|
20671916 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to investigate the relationship between polymorphisms of IL-1beta promoter region -511C/T and IL-1 receptor antagonist (IL-1Ra) gene (IL-RN) and bronchial asthma in Turkish children.
|
18926055 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We demonstrate the method by building two complex gene-SNP networks around Interferon Receptor 12B2 (IL12RB2) and Interleukin 1B (IL1B), two biologic candidates in asthma pathogenesis, using 534,290 genotyped variants and gene expression data on 22,177 genes from total RNA derived from peripheral blood CD4+ lymphocytes from 154 asthmatics.
|
19473523 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The allele and genotype frequencies of a number polymorphic genes coding for tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 alpha, IL-1 beta, IL-1 receptor (IL-1R), IL-1RA, and IL-6 were investigated in 60 patients with asthma in comparison with 140 controls using polymerase chain reaction with sequence-specific primers.
|
18763028 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
IL-33, a new member of the IL-1 cytokine family, promotes Th2 inflammation, but evidence on the implications of this cytokine in asthma is lacking.
|
19801525 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
These results indicate that enhanced synthesis of HA by the proinflammatory cytokines IL-1beta and TNF-alpha can be abrogated by specific corticosteroid and beta2 blocker combinations shown to be effective in the treatment of asthma.
|
14764429 |
2004 |