|
Congenital heart disease
|
0.010 |
Biomarker
|
group |
BEFREE |
The importance of the anti-inflammatory mediators IL-1ra and IL-10, as well as cytokines Epo and VEGF, which could impact on the pathogenesis and outcomes in congenital heart disease (CHD) which is more prevalent in DS, are less well known.
|
31785499 |
2020 |
|
Idiopathic generalized epilepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
<b>Background:</b> Neuroinflammation is an important feature of epileptogenesis.<b>Objectives:</b> To investigate the association of Interleukin-1beta-31 (IL-1β-31) and Interleukin-1 receptor antagonist (IL1-RA) genetic polymorphisms with idiopathic generalized epilepsy and demonstrate their influence on drug resistance in children.<b>Materials and Methods:</b> One hundred children with idiopathic generalized epilepsy were age and gender-matched with apparently healthy controls.
|
31698971 |
2020 |
|
Seizure, Febrile, Complex
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid levels of granzyme A were significantly higher, and those of TNF-α and IL-1RA were significantly lower in the AE group than in the cFS group; however, no significant differences in the levels of granzyme B, IFN-γ, IL-1β, IL-4, IL-6, IL-8, and IL-10 were observed between the 2 groups.
|
31709864 |
2020 |
|
Acute encephalopathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cerebrospinal fluid levels of granzyme A were significantly higher, and those of TNF-α and IL-1RA were significantly lower in the AE group than in the cFS group; however, no significant differences in the levels of granzyme B, IFN-γ, IL-1β, IL-4, IL-6, IL-8, and IL-10 were observed between the 2 groups.
|
31709864 |
2020 |
|
Bacteroides fragilis infection in conditions classified elsewhere and of unspecified site
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The high-risk tumors overexpressed IL23A and IL1RN genes and enriched with cancer-related bacteria (Bacteroides fragilis,Peptostreptococcus, Parvimonas, Alloprevotella and Gemella) compared to the low-risk tumors.
|
31693169 |
2020 |
|
Periodontal inflammation
|
0.010 |
Biomarker
|
disease |
BEFREE |
Preparation and Evaluation of IL-1ra-Loaded Dextran/PLGA Microspheres for Inhibiting Periodontal Inflammation In Vitro.
|
31664694 |
2020 |
|
Secondary haemophagocytic lymphohistiocytosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
To assess the benefit of the recombinant human interleukin-1 receptor antagonist, anakinra, in treating pediatric patients with secondary hemophagocytic lymphohistiocytosis (sHLH) / macrophage activation syndrome (MAS) associated with rheumatologic and non-rheumatologic conditions.
|
31513353 |
2020 |
|
Adenovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Responses of several cytokines such as IL-1RA, IL-21 and all of the chemokines were found after adenovirus infection.
|
30217569 |
2019 |
|
Primary Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that both SLAMF7<sup>high</sup> monocytes and IL-1ra could be useful noninvasive markers of MF onset.
|
31270105 |
2019 |
|
Aortic Aneurysm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, BM-MSCs and MSCs-CM reduced MCP-1, IL-1Ra and IL-6 expression and increased IL-10 expression in AA tissues.
|
31583844 |
2019 |
|
Chikungunya Fever
|
0.010 |
Biomarker
|
disease |
BEFREE |
The results also revealed a higher production of IL-1 RN protein in patients with chronic chikungunya.
|
31294845 |
2019 |
|
Dental caries
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant difference was found in the alleles and genotypes of five genes ( ENAM, TUFT1, MMP13, IL10 and IL1RN) between those with and without dental caries.
|
30803280 |
2019 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we demonstrated that methionine deprivation inhibited glioma cell proliferation via downregulating interleukin 1 receptor antagonist (IL1RN) both in vitro and in vivo, methionine deprivation or knocking down IL1RN induced glioma cell cycle arrest.
|
30978442 |
2019 |
|
Leishmaniasis, Cutaneous
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The SNPs -511T/C (rs16944) and +3954C/T (rs1143634) of the IL1B and IL1RN VNTR (rs2234663) were assessed in 881 patients with CL and 837 healthy controls by PCR-RFLP and direct PCR respectively.
|
31357078 |
2019 |
|
Mycoses
|
0.010 |
Biomarker
|
group |
BEFREE |
Administration of human recombinant IL-1RA (Kineret/anakinra) during fungal-associated allergic airway inflammation improved airway hyperreactivity and lowered type 1 and type 17 responses.
|
31550242 |
2019 |
|
Myelofibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that both SLAMF7<sup>high</sup> monocytes and IL-1ra could be useful noninvasive markers of MF onset.
|
31270105 |
2019 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A peptide derived from melanotransferrin delivers a protein-based interleukin 1 receptor antagonist across the BBB and ameliorates neuropathic pain in a preclinical model.
|
29845881 |
2019 |
|
Bullous pemphigoid
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrated that several markers related to the alternatively activated macrophage phenotype (M2) including IL-10, TARC, arginase, TNFα, and IL-1RA were meaningfully increased in BF of patients with BP.
|
31440247 |
2019 |
|
Peripheral Neuropathy
|
0.010 |
Biomarker
|
group |
BEFREE |
IL-1RA transiently abolishes allodynia in PAE rats, suggesting that IL-1β is in part, necessary for the susceptibility of adult-onset peripheral neuropathy caused by PAE.
|
30961664 |
2019 |
|
Tinnitus
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Moreover, this issue addresses how oral hygiene is a concern for the entire organism, that younger age goes well with neoadjuvant chemotherapy for breast cancer and zinc with feeling less distressed by tinnitus caused by noise-induced hearing loss, and that IL-1Ra holds very promising potential to prevent intestinal ischemia reperfusion injury.
|
30987700 |
2019 |
|
African Trypanosomiasis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The minor allele T and the genotype TT of SNP rs1800794 in IL1A as well as the genotype 1A3A of IL1RN rs2234663 VNTR seem to increase the risk of getting Trypanosoma brucei gambiense infections and develop sleeping sickness in southern Cameroon.
|
30908482 |
2019 |
|
Urinary tract infection
|
0.010 |
Biomarker
|
group |
BEFREE |
However, the effects of IL-1R antagonist (IL-1RA) on immune responses during UTI, except for its ability to disrupt IL-1β signalling, are not well understood.
|
31299415 |
2019 |
|
Ventricular arrhythmia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, treatment of I/R-WT mice with IL-1r antagonist (IL-1ra) from 8 to 15 days post perfusion did not interfere with renal function, but reversed QJ prolongation, prevented the increase in susceptibility to ventricular arrhythmias and rescued a close to normal duration and amplitude of calcium transient.
|
31029578 |
2019 |
|
Primary gout
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this retrospective observational study, we assess the efficacy and safety of the interleukin 1 receptor antagonist anakinra in medically complex, hospitalized patients with acute gout and calcium pyrophosphate crystal arthritis.
|
30647192 |
2019 |
|
Cutaneous Melanoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interleukin 1 receptor antagonist gene variable number of tandem repeats polymorphism and cutaneous melanoma.
|
31788049 |
2019 |